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	题名	作者	年代	出处	被引量
1	An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。	Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley	2014	Cell Research2014，24，7：	10
2	Pancreatic cancer expresses adiponectin receptors and is associated with hypoleptinemia and hyperadiponectinemia: a case–control study显示文摘	Maria Dalamaga Ilias Migdalis Jessica L. Fargnoli Evangelia Papadavid Erica Bloom Nicholas Mitsiades Konstantinos Karmaniolas Nicolaos Pelecanos Sofia Tseleni-Balafouta Amalia Dionyssiou-Asteriou Christos S. Mantzoros	2009	Cancer Causes & Control2009，，5：	3
3	Integrative Genomic Profiling of Human Prostate Cancer显示文摘	Barry S. Taylor Nikolaus Schultz Haley Hieronymus Anuradha Gopalan Yonghong Xiao Brett S. Carver Vivek K. Arora Poorvi Kaushik Ethan Cerami Boris Reva Yevgeniy Antipin Nicholas Mitsiades Thomas Landers Igor Dolgalev John E. Major Manda Wilson Nicholas D.	2010	Cancer Cell2010，，：	2
4	Antimyeloma effi cacy of plitidepsin ( aplidin (R) ) : from bench to the bedside 显示文摘	Ocio EM Mitsiades C Mateos MV	2007	Blood2007，，：	1
5	Novel histone deacetylase inhibitors in the treatment of thyroid cancer显示文摘	MITSIADES C S POULAKI V MCMULLAN C	2005	Clin Cancer Res2005，15，：	1
6	Fas ligand expression in thyroid follicular cells from patients with thionamide-treated Graves′ disease显示文摘	Mitsiades N Poulaki V Tseleni Balafouta S		0，，：	1
7	VEGF-dependent conjunctivalization of the corneal surface 显示文摘	JOUSSEN A M POULAKI V MITSIADES N	2003	Invest Ophthalmol Vis Sci2003，44，1：	1
8	Thyroid carcinoma cells are resistant to FAS-mediatedd apoptosis but sensitibe to tumor necrosis factor-related apoptosis-inducing ligand显示文摘	Mitsiades N Poulaki V Sophia TB	2000	Cancer Res2000，60，15：	1
9	Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma :therapeutic applications 显示文摘	Mitsiades N Mitsiades CS Poulaki V	2002	Blood2002，99，11：	1
10	Regulation of vascular endothelial growth factor expression by insulin-like growth factorⅠin thyroid carcinomas显示文摘	Poulaki V Mitsiades CS Mc Mullan C	2003	J Clin Endocrinol Metab2003，88，11：	1
11	Molecular pathology of thyroid cancer: diagnostic and clinical implications 显示文摘	Fagin JA Mitsiades N	2008	Best Pract Res Clin En- docrinol Metab2008，22，6：	1
12	Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells : therapeutic implications 显示文摘	Mitsiades N Mitsiades CS Poulaki V	2002	Blood2002，99，12：	1
13	Bortezomib:proteasome inhibition as an effective anticancer therapy显示文摘	Richardson PG Mitsiades C	2006	Annu Rev Med2006，57，：	1
14	The proteasome inhibitor PS - 341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents 显示文摘	Mitsiades N Mitsiades CS Richardson PG	2003	Clin Cancer Res2003，9，3：	1
15	The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents:therapeutic applications显示文摘	Mitsiades N Mitsiades C S Richardson PG	2003	Blood2003，101，6：	1
16	VEGF-dependent eonjunetivalizafion of the corneal surface 显示文摘	Joussen AM Poulaki V Mitsiades N	2003	Invest Ophthalmol Vis Sei2003，44，1：	1
17	Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo显示文摘	Joussen AM Poulaki V Qin W Kirchhof B Mitsiades N Wiegand SJ	2002	Am J Pathol2002，160，2：	1
18	Regulation of Apo2L/tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis in Thyroid Carcinoma Cells 显示文摘	Poulaki V Mitsiades C S Kotoula V	2002	Am J Pathol2002，161，：	1
19	显示文摘	Mitsiades N Poulaki V Tseleni-Balafouia S	2000	Thyroid2000，10，：	1
20	Fas ligand is present in tumors of the Ewing's sarcoma family and is cleaved intoa soluble form by a metalloproteinase 显示文摘	Mitsiades N Piulaki V Kotoula V	1998	Am J Pathol1998，153，6：	1

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