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| 1 | Rho A signaling and blood pressure: The consequence of failing to “Tone it Down”显示文摘Uncontrolled high blood pressure is a major risk factor for heart attack, stroke, and kidney failure and contributes to an estimated 25% of deaths worldwide. Despite numerous treatment options, estimates project that reasonable blood pressure(BP) control is achieved in only about half of hypertensive patients. Improvements in the detection and management of hypertension will undoubtedly be accomplished through a better understanding of the complex etiology of this disease and a more comprehensive inventory of the genes and genetic variants that influence BP regulation. Recent studies(primarily in pre-clinical models) indicate that the small GTPase Rho A and its downstream target, Rho kinase, play an important role in regulating BP homeostasis. Herein, we summarize the underlying mechanisms and highlight signaling pathways and regulators that impart tight spatial-temporal control of Rho A activity. We also discuss known allelic variations in the Rho A pathway and consider how these polymorphisms may affect genetic risk for hypertension and its clinical manifestations. Finally, we summarize the current(albeit limited) clinical data on the efficacy of targeting the Rho A pathway in hypertensive patients. | Xue Bai Rachel Dee Kevin D Mangum Christopher P Mack Joan M Taylor | 2016 | World Journal of Hypertension2016，6，1： | 3 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | High C-reactive protein and low paraoxonasel in diabetes as risk factors for coronary heart disease 显示文摘 | Mackness B Hine D McElduff P | 2006 | Atherosclerosis2006，186，2： | 1 |
| 4 | Synthesis of Poly 显示文摘 | Allcock H R Fuller T J Mack D P | 1977 | Macromolecules1977，10，4： | 1 |
| 5 | High C-reactive protein and low paraoxonase 1 in diabetes as risk factor for cor- onary heart disease 显示文摘 | Mackness B Hine D McElduff P Mackness M | 2006 | Atherosclerosis2006，186，2： | 1 |
| 6 | Association of epidermal growth factor receptor activating mutations with low ERCC1 gene expression in non-small cell lung cancer显示文摘 | GANDARA D R GRIMMINGER P MACK P C | 2010 | J Thorac Oncol2010，5，12： | 1 |
| 7 | Microbial interactions in Staphylococcus epidermidis biofilms显示文摘 | Mack D Davies A P Harris L G | 2007 | Anal Bioanal Chem2007，387，2： | 1 |
| 8 | Analysis of pesticide residues using the Quick Easy Cheap Effective Rugged and Safe(QuEChERS)pesticidemultiresidue method in combination with gas and liquid chromatography and tandem mass spectrometric detection显示文摘 | PAYA P ANASTASSIADES M MACK D SIGALOVA I TASDELEN B OLIVA J BARBA A | 2007 | Anal Bioanal Chem2007，389，6： | 1 |
| 9 | Nickel- mediated sequence-specific oxidative cleavage of DNA by a designed metalloprotein显示文摘 | MACK D P DERYAN P B | 1990 | J Am Chem Soc1990，112，： | 1 |
| 10 | Development and preliminary validation of heart rate and breathing rate detection using a passive,ballistocardiography-based sleep monitoring system显示文摘 | MACK D C PATRIE J T SURATT P M FELDER R A ALWAN M | 2009 | IEEE Transactions on Information Technology in Biomedicine2009，13，1： | 1 |
| 11 | 2012 ACCF/AATS/SCAI/STS expert consensus document on transcatheter aorticvalve replacement :developed in collabration with theAmerican Heart Association,American Society of Ech-ocardiography,European Association for Cardio-Tho-racic Surgery? Heart Failure Society of America* Men-ded Hearts,Society of Cardiovascular Anesthesiolo-gists,Society of Cardiovascular Computed Tomo-graphy?and Society for Cardiovascular Magnetic Reso-nance 显示文摘 | Holmes D R Jr Mack M J Kaul S Agnihotri A Alex-ander K P Bailey S R | 2012 | J Thorac Cardiovasc Surg2012，144，： | 1 |
| 12 | Combined intermittent dearterialization and intraperitoneal 5-fluorouracil administration for liver tumours in the rat 显示文摘 | Mack P Jeppsson B Widlus D | 1988 | Eur J Cancer Clin Oncol1988，24，5： | 1 |
| 13 | Analysis of pesticide residues using the quick easy cheap effective rugged and safe (QuEChERS)pesticide multiresidue method in combination with gas and liquid chromatography and tandem mass spectrometric detection显示文摘 | PAYA P ANASTASSIADES M MACK D | 2007 | Anal Bioanal Chem2007，389，： | 1 |
| 14 | Postoperative narcotic re-quirement after microscopic lumbar discectomy is not affected by intraoperative ketorolaqc or bupivacaine显示文摘 | Mack P F Hass D Lavyne M H | | 0，，： | 1 |
| 15 | The response of native species to removal of invasive exotic grasses in a seasonally dry hawaiian woodland显示文摘 | D'Antonio C M Hughes R F Mack M Hitchcock D Vitousek P M | 1998 | Journal of Vegetation Science1998，9，5： | 1 |
| 16 | Nickel-mediated squencespecific oxidative cleavage of DNA by a designed metalloprotein 显示文摘 | Mack D P Dervan P B | 1990 | J Am Chem Soc1990，112，： | 1 |
| 17 | An Anatomy of Price Dynamics in Illiquid Markets: Analysis and Evidence from Local Housing Markets 显示文摘 | Capozza D Hendershott P and C Mack | 2004 | Real Estate Economics2004，32，： | 1 |
| 18 | An Anatomy of Price Dynamics in Illiquid Markets: Analysis and Evidence from Local Housing Markets 显示文摘 | Capozza D Hendershott P Mack C | 2004 | Real Estate E-conomics2004，32，： | 1 |
| 19 | Macromolecules 显示文摘 | Allcock H R Fuller T J Mack D P | 1977 | 10(4): 824-8301977，10，4： | 1 |
| 20 | Mechanisms of biofilm formation in Staphylococcus epidermidis and Staphylococcus aureus: functional molecules, regulatory circuits, and adaptive responses显示文摘 | Mack D Becker P Chatterjee I | 2004 | Int J Med Microbiol2004，294，23： | 1 |
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