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| 1 | Hepatic flow is an intraoperative predictor of early allograft dysfunction in whole-graft deceased donor liver transplantation: An observational cohort study显示文摘BACKGROUND Early allograft dysfunction(EAD)after liver transplantation(LT)is an important cause of morbidity and mortality.To ensure adequate graft function,a critical hepatocellular mass is required in addition to an appropriate blood supply.We hypothesized that intraoperative measurement of portal venous and hepatic arterial flow may serve as a predictor in the diagnosis of EAD.AIM To study whether hepatic flow is an independent predictor of EAD following LT.METHODS This is an observational cohort study in a single institution.Hepatic arterial blood flow and portal venous blood flow were measured intraoperatively by transit flow.EAD was defined using the Olthoff criteria.Univariate and multivariate analyses were used to determine the intraoperative predictors of EAD.Survival analysis and prognostic factor analysis were performed using the Kaplan-Meier and Cox regression models.RESULTS A total of 195 liver transplant procedures were performed between January 2008 and December 2014 in 188 patients.A total of 54(27.7%)patients developed EAD.The median follow-up was 39 mo.Portal venous flow,hepatic arterial flow(HAF)and total hepatic arterial flow were associated with EAD in both the univariate and multivariate analyses.HAF is an independent prognostic factor for 30-d patient mortality.CONCLUSION Intraoperative measurement of blood flow after reperfusion appears to be a predictor of EAD;Moreover,HAF should be considered a predictor of 30-d patient mortality. | Pablo Lozano Lominchar Maitane Igone Orue-Echebarria Lorena Martín Cristina Julia Lisbona María Magdalena Salcedo Luis Olmedilla Hemant Sharma Jose Manuel Asencio JoséAngel López-Baena | 2019 | World Journal of Hepatology2019，11，9： | 4 |
| 2 | Tumour prothymosin alpha content, a potential prognostic marker for primary breast cancer显示文摘 | Magdalena C Dominguez F Loidi L | 2000 | Br J Cancer2000，82，3： | 1 |
| 3 | The problem of solid state hydrogen storage显示文摘 | Principi G Agreste F Magdalena A Russo S L | | 0，，12： | 1 |
| 4 | Combined genotypes of CCR5, CCR2, SDF1, and HLA genes can predict the long-term nonprogressor status in HIV-1 infected individuals显示文摘 | Magdalena M Theodorou L Debre P | 1999 | Blood1999，93，3： | 1 |
| 5 | Tumour prothymosin alpha content,a potential prognosticmarker for primary breast cancer 显示文摘 | MAGDALENA C DOMINGUEZ F LOIDI L | 2000 | Br J Cancer2000，82，3： | 1 |
| 6 | Androgen, progesterone, and FSH receptor polymorphisms in ovarian cancer risk and outcome 显示文摘 | Agnieszka H L Magdalena M Grzegorz P | 2009 | Endocr Relat Cancer2009，16，3： | 1 |
| 7 | Prognostic impact of immuno histochemieally defined germinal center phenotype in dffuse large B-cell lymphoma patients treated with inununochemotherapy显示文摘 | Heidi N Magdalena A Marja L | 2007 | Blood2007，10，11： | 1 |
| 8 | Ozonation reduces sludge production and improves denitrification显示文摘 | MAGDALENA A D KATHLEEN L L HANSRUEDI S | 2007 | Water Res2007，41，3： | 1 |
| 9 | Knowledge-based intelligent diagnosis of ground robot collision with non detectable obstacle显示文摘 | Alonso J M Magdalena L Guillaume S | | 0，，： | 1 |
| 10 | CpG oligonucleotide therapy cures subcutaneous and orthotopic tumors and evokes protective immunity in murine bladder cancer显示文摘 | Christina N Angelica L Magdalena K | 2005 | J Immunother2005，28，： | 1 |
| 11 | Posterior alien hand syndrome after a rught thalamic in- farct显示文摘 | Marey- Lopez J Rubio- Nazabal E Alonso- Magdalena L | 2002 | Neurol Neurosurg Psychiatry2002，73，： | 1 |
| 12 | Interactions of free copper (Ⅱ) ions alone or incomplex with iron ( Ⅲ ) ions with erythrocytes of ma- rine fish Dicentrarchus labrax 显示文摘 | MAGDALENA L KATARAYNA M ANETA B | 2009 | Cell Biol Int2009，33，： | 1 |
| 13 | Towards the sustainable use of water: a regional approach for Baden-Wurttemberg 显示文摘 | Magdalena S Helmut L | 1999 | Germany Water Resources Development1999，15，3： | 1 |
| 14 | Continuous enzymatic regeneration of electron acceptors used by flavoenzyrnes: cellobiose de- hydrogenase-eatalyzed production of lactobionic acid as an example显示文摘 | ROLAND L MAGDALENA O MARCEL Z | 2004 | Biocat Biotransf2004，22，2： | 1 |
| 15 | Salinity and nitrogen rate effects on the growth and yield chile pepper plant显示文摘 | Magdalena V C April L U Ernesto A C | 2003 | Soil Science Society of America Journal2003，，67： | 1 |
| 16 | FOLFIRI3-aflibercept in previously treated patients with metastatic colorectal cancer显示文摘AIM To evaluate the efficacy and safety of the modified FOLFIRI3-aflibercept as second-line therapy in patients with metastatic colorectal cancer.METHODS This is a retrospective multicenter cohort, evaluating the efficacy and safety of the association of aflibercept with FOLFIRI3(day 1: aflibercept 4 mg/kg, folinic acid 400 mg/m^2, irinotecan 90 mg/m^2, 5-fluorouracil infusion 2400 mg/m^2 per 46 h; day 3: irinotecan 90 mg/m^2) in patients with previously treated metastatic colorectal cancer. The primary endpoint was overall response rate(ORR). Secondary endpoints were disease control rate(DCR), progression-free survival(PFS), overall survival(OS), and safety.RESULTS Among 74 patients treated in four French centers, nine were excluded due to prior use of aflibercept(n = 3), more than one prior treatment line in irinotecanna?ve patients(n = 3), and inadequate liver function(n = 3). In the 'irinotecan-na?ve' patients(n = 30), ORR was 43.3% and DCR was 76.7%. Median PFS and OS were 11.3 mo(95%CI: 6.1-29.0) and 17.0 mo(95%CI: 13.0-17.3), respectively. The most common(> 5%) grade 3-4 adverse events were diarrhea(37.9%), neutropenia(14.3%), stomatitis and anemia(10.4%), and hypertension(6.7%). In the 'pre-exposed irinotecan' patients(n = 35), 20(57.1%) received ≥ 2 prior lines of treatment. ORR was 34.3% and DCR was 60.0%. Median PFS and OS were 5.7 mo(95%CI: 3.9-10.4) and 14.3 mo(95%CI: 12.8-19.5), respectively.CONCLUSION Minimally modified FOLFIRI has improvement dramatically the FOLFIRI3-aflibercept efficacy, whatever prior use of irinotecan. A prospective randomized trial is warranted to compare FOLFIRI-aflibercept to FOLFIRI3-aflibercept. | CANDice Carola Fran?ois Ghiringhelli Stefano Kim Thierry ANDré Juliette Barlet Le?la Bengrine-Lefevre Hélène Marijon Marie-Line Garcia-Larnicol Christophe Borg Linda Dainese Nils Steuer Hubert Richa Magdalena Benetkiewicz Annette K Larsen Aimery de Gramont Benoist Chibaudel | 2018 | World Journal of Clinical Oncology2018，9，5： | 1 |
| 17 | Tumour prothymosinalpha content,a potential prognostic marker for primary breastcancer显示文摘 | Magdalena C Dominguez F Loidi L | 2000 | Br J Cancer2000，82，3： | 1 |
| 18 | The study of marine corrosion of copper alloys in chlorinated condenser cooling circuits: The role of microbiological components显示文摘 | Carvalho Maria L Jemimah Doma Magdalena Sztyler | 2014 | Bioelectrochemist2014，97，： | 1 |
| 19 | Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with acute and chronic pancreatitis显示文摘 | WOJCIECH J EMILIA K MAGDALENA L D | | 0，，： | 1 |
| 20 | Ozonation reduces sludge production and improves denitrification显示文摘 | Magdalena A Kathleen L Siegrist | 2007 | Water Research2007，41，3： | 1 |
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