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| 1 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 2 | 学历与一生的收入:德国最新的有关调查统计(上)显示文摘教育是一项耗费时间、精力和财力的投资。如果考虑劳动力市场以后给与的回报,这种投资是否值得?我们运用标准的净现值法,以德国当前的居民年龄与收入状况为基础,利用2011—2013年德国微观人口普查中超过100万人的数据,对不同受教育程度人群进行分类并计算他们之间终生收入的差异。研究结果表明,在整个职业生涯中,每一个较高的学历都会带来多出22%到64%的收入。但是,地域、性别,特别是职业培训和大学教育的不同专业也是影响收入差距的重要因素,例如医学和社会工作之间的差异就很大。 | Marc Piopiunik Franziska Kugler Ludger Wβmann 陈颖 | 2017 | 应用型高等教育研究2017，2，4： | 2 |
| 3 | Corrosion of mild steel under heat transfer in high temperature aerated sodium chloride solutions显示文摘 | Ashford J H Garnsey R Mann G H W | 1974 | Corrosion Science1974，，14： | 2 |
| 4 | The oxidation of iron-chromium alloys in ferrous chloride solution at 300℃显示文摘 | Mann M W Teare P W | 1972 | Corrosion Science1972，，12： | 2 |
| 5 | Mean value methods in iteration显示文摘 | MANN W R | 1953 | Proe Amer Math Soc1953，4，： | 1 |
| 6 | 4-n-butylresorcinol, a highly ef- fective lyrosinase inhibitor for the topical treatment of hyperpigmen- tation 显示文摘 | Kolbe L Mann T Gerwat W | 2013 | Journal of the European Academy of Dermatology and Venereology2013，27，1： | 1 |
| 7 | A five body--Three dimensional dynamic analysis of walking 显示文摘 | Hardt D E Mann R W | 1980 | Journal of Biomechanics1980，13，5： | 1 |
| 8 | Montoring and verifying changes of organic carbon in vsoil显示文摘 | Post W M Izaurralde R C Mann L K | 2001 | ClimaticChange2001，51，： | 1 |
| 9 | Vapor-liq- uid equilibrium data for propylene-propane system 显示文摘 | MANN A N PARDEE W A SMYTH R W | 1963 | J Chem Eng Data1963，8，4： | 1 |
| 10 | The impact of the methotrexate administration schedule and dose in the treatment of children and adolescents with B-cell neoplasms : a report of the BFM Group Study NHL-BFM95显示文摘 | Woessmann W Seidemann K Mann G | 2005 | Blood2005，105，3： | 1 |
| 11 | A boundless future for proteomics显示文摘 | Mann M | 2001 | Trends Biotechnol2001，，： | 1 |
| 12 | The movement and entrapment of petroleum fluids in the subsurface显示文摘 | England W A Mackenzie A S Mann D M | 1987 | Journal ofthe Geological Society1987，144，2： | 1 |
| 13 | Impaired pituitary hormonal respon se to exhaustive exercise in overt rained endurance athletes显示文摘 | Urhausen A Gabriel HW Kinder Mann W | 1998 | Med Sci Sports Exerc1998，30，3： | 1 |
| 14 | Application of the mobile metal ion technique to routine geochemical exploration 显示文摘 | Mann A W Birrell R D Mann A T | 1998 | Journal of Geochemical Exploration1998，61，： | 1 |
| 15 | Respiratory tract mucins: structure and expression patterns 显示文摘 | Davies J R Hen'mann A Russell W | 2002 | Novartis Found Symp2002，248，： | 1 |
| 16 | The movement and entrapment of petroleum fluids in the subsurface 显示文摘 | England W Mackenzie A Mann D | 1987 | Journal of the Ge- ological Society1987，144，2： | 1 |
| 17 | DNA methylation is a primary mechanism for silencing postmigratory primordial germ cell genes in both germ cell and somatic cell lineages显示文摘 | Maatouk D.M Kellam L.D Mann M.R W Lei H Li E Bartolomei M.S Rcsnick J.L | | 0，，17： | 1 |
| 18 | Mean value methods in iteration显示文摘 | MANN W R | 1953 | Proc Amer Math Soc1953，4，： | 1 |
| 19 | Vertical ionic migration: mechanisms, soft anomalies, and sampling depth for mineral exploration显示文摘 | Mann A W Birrell R D Fedikow A F | 2005 | Geochemistry: Exploration Environment Analysis2005，5，： | 1 |
| 20 | Characterization of microstructural anisotropy in orthotropic materials using a second rank tensor 显示文摘 | HARRIGAN T P MANN R W | 1984 | J Mater Sei1984，19，3： | 1 |
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