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| 1 | Transcranial direct current stimulation in psychiatric disorders显示文摘The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally,we provide an overview of t DCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding t DCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding t DCS efficacy in psychiatry. | Gabriel Tortella Roberta Casati Luana V M Aparicio Antonio Mantovani Natasha Senco Giordano D’Urso Jerome Brunelin Fabiana Guarienti Priscila Mara Lorencini Selingardi Débora Muszkat Bernardo de Sampaio Pereira Junior Leandro Valiengo Adriano H Moffa Marcel Simis Lucas Borrione André R Brunoni | 2015 | World Journal of Psychiatry2015，5，1： | 6 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | A rapid and novel alternative to conventional sample treatment for arsenic speciation in rice using enzymatic ultrasonic probe显示文摘 | E SANZ R MNOZ-OLIVAS C CáMARA | 2005 | Analytica Chimica Acta2005，，535： | 1 |
| 4 | High-temperature mechanical behavior/ microstructurecorrelation of Cu/Nb nanoscale multilayers 显示文摘 | MARA N A MISTRA A HOAGLAND R G | 2008 | Materials Science and Engineering : A2008，493，： | 1 |
| 5 | Impacts ofstress and disturbance factors on the phytoplankton communities inNortheastern Brazil reservoir显示文摘 | CHELLAPPA N T CHELLAPPA T C MARA F R A | 2009 | Limnologica2009，39，： | 1 |
| 6 | Application of PLS and back-propagation neural networks for the estimation of soil properties显示文摘 | ZIAD R PHILIP K H MARA J J | 2005 | Chemometrics and Intelligent Laboratory Systems2005，75，1： | 1 |
| 7 | Crop residue influences on soil carbon and nitrogen in a wheat-fallow system显示文摘 | Rasmussen P E All maras R R Roager Jr N C | 1980 | Soil Science Society of American Journal1980，44，7： | 1 |
| 8 | A Friend in Need:The Role of Friendship Quality as a Protective Factor in Peer Victimization and Bullying显示文摘 | Milich R Maras M A | 2005 | Journal of Interpersonal Violence2005，，6： | 1 |
| 9 | Dispersion and treatment performance analysis of an UASB reactor under different hydraulic loading rates 显示文摘 | Pena M R Mara D D Avella G P | 2006 | Water Research2006，40，44： | 1 |
| 10 | River-sea shipping-competitiveness of various transport technologies 显示文摘 | RADMILOVIC Z ZOBENICA R MARA V | 2011 | J Transport Geography2011，19，6： | 1 |
| 11 | Studies on the evolution of ZnO morphologies in a thermohydrolysis technique and evaluation of their functional properties显示文摘 | ANASA S MANGALARAJAB R V ANANTHAKU- MARA S | 2010 | Journal of Hazardous Materials2010，175，： | 1 |
| 12 | Methionine concentration in the diet has a tissue-specific effect on chromosomal stability in female mice显示文摘 | Aissa A F Uraula H G T D Mara R | 2013 | Food and Chemical Toxicology2013，62，： | 1 |
| 13 | Genetic polymorphisms in the human tissue kallikrein (KLK) locus and their implication in various malignant and non-malignant diseases显示文摘 | Batra J O' Mara T Patnala R | | 0，，12： | 1 |
| 14 | Extraction and immobilization in one step of two-glucosidase released from a yeast strain of Debaryomyces hansenii显示文摘 | PAOLO R ROCCO R MARA V | 1999 | Enzyme Microbiol Technol1999，，24： | 1 |
| 15 | Unconjugated hyperbilirubinemiain patients with non-alcoholic fatty liver disease: a favorable endogenousresponse显示文摘 | Kumar R Rastogi A Maras JS | 2012 | Clin Biochem2012，45，： | 1 |
| 16 | Dietary corn germ containing pheytic acid prevents pork meat lipid oxidation while maintaining normal animal growth performance显示文摘 | Ana Paula R Harbach Mara C R da Costa | 2007 | Food Chemistry2007，100，： | 1 |
| 17 | Water and Excreta-Related Disease:Unitary Environmental Classification显示文摘 | Mara D D R G A Feachem | 1999 | Journal of Environmental Engineering1999，4，： | 1 |
| 18 | Genetic polymorphisms in the human tissue kallikrein (KLK) locus and their implication in various malignant and non-malignant diseases显示文摘 | Batra J O'Mara T Patnala R | | 0，，12： | 1 |
| 19 | Potentialities of two solventless extraction approaches-stir bar sorptive extraction and headspace solid-phase microextraction for determination of higher alcohol acetates,isoamyl esters and ethyl esters in wines显示文摘 | PERESTRELO R NOGUEIRA J M C(A)MARA J S | | 0，，02： | 1 |
| 20 | Engineering vascularized skeletalmuscle tissue 显示文摘 | Shulamit L Jeroen R Mara M | 2005 | Nature Biotechnology2005，23，7： | 1 |
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