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| 1 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 2 | Management of hepatitis C in patients with chronic kidney disease显示文摘Hepatitis C virus(HCV) infection is highly prevalent among chronic kidney disease(CKD) subjects under hemodialysis and in kidney transplantation(KT) recipients, being an important cause of morbidity and mortality in these patients. The vast majority of HCV chronic infections in the hemodialysis setting are currently attributable to nosocomial transmission. Acute and chronic hepatitis C exhibits distinct clinical and laboratorial features, which can impact on managementand treatment decisions. In hemodialysis subjects, acute infections are usually asymptomatic and anicteric; since spontaneous viral clearance is very uncommon in this context, acute infections should be treated as soon as possible. In KT recipients, the occurrence of acute hepatitis C can have a more severe course, with a rapid progression of liver fibrosis. In these patients, it is recommended to use pegylated interferon(PEG-IFN) in combination with ribavirin, with doses adjusted according to estimated glomerular filtration rate. There is no evidence suggesting that chronic hepatitis C exhibits a more aggressive course in CKD subjects under conservative management. In these subjects, indication of treatment with PEG-IFN plus ribavirin relies on the CKD stage, rate of progression of renal dysfunction and the possibility of a preemptive transplant. HCV infection has been associated with both liver disease-related deaths and cardiovascular mortality in hemodialysis patients. Among those individuals, low HCV viral loads and the phenomenon of intermittent HCV viremia are often observed, and sequential HCV RNA monitoring is needed. Despite the poor tolerability and suboptimal efficacy of antiviral therapy in CKD patients, many patients can achieve sustained virological response, which improve patient and graft outcomes. Hepatitis C eradication before KT theoretically improves survival and reduces the occurrence of chronic graft nephropathy, de novo glomerulonephritis and post-transplant diabetes mellitus. | Roberto J Carvalho-Filho Ana Cristina CA Feldner Antonio Eduardo B Silva Maria Lucia G Ferraz | 2015 | World Journal of Gastroenterology2015，21，2： | 4 |
| 3 | Central nervous system vasculitis and polyneuropathy as first manifestations of hepatitis C显示文摘Sensory or motor peripheral neuropathy may be observed in a significant proportion of hepatitis C virus (HCV)-infected patients.However,central nervous system (CNS) involvement is uncommon,especially in cryoglobulin-negative subjects.We describe a case of peripheral neuropathy combined with an ischemic CNS event as primary manifestations of chronic HCV infection without cryoglobulinemia.Significant improvement was observed after antiviral therapy.We discuss the spectrum of neurological manifestations of HCV infection and review the literature. | Roberto J Carvalho-Filho Janaína Luz Narciso-Schiavon Luciano HL Tolentino Leonardo L Schiavon Maria Lucia G Ferraz Antonio Eduardo B Silva | 2012 | World Journal of Gastroenterology2012，18，2： | 3 |
| 4 | Quantification of Listeria monoeytogenes in minimally processed leafy vegetables using a combined method based on enrichment and 16SrRNAreal-time PCR显示文摘 | Maria A O Eliana G R Alzira M B | 2010 | Food Microbiology2010，，27： | 1 |
| 5 | Annual variation of airborne pollen in the city of Bahia,Argenting显示文摘 | Murray Maria G Sonaglioni Monica I Villamil Carlos B | 2002 | Grana2002，41，3： | 1 |
| 6 | Development of a biosensor microarray towards food screening using imaging surface plasmon resonance 显示文摘 | SABINA R R MARIA G B GIESBERS M | 2008 | Biosensors and Bioelectronics2008，24，： | 1 |
| 7 | Evolution of octopod sperm Ⅰ:Comparison of nuclear morphogenesis in Eledone and Octopus显示文摘 | PEPITA G B ENRIC R MARIA J Z | | 0，，62： | 1 |
| 8 | Capillary electrophoresis of free fatty acids by indirect uhraviolet 显示文摘 | Maria V B Aaron E D Maria J L G | 2011 | Journal of Agriculture and Food Chemistry2011，59，10： | 1 |
| 9 | Mandarin peel wastespretreatment with steam explosion for bioethanol production显示文摘 | MARIA B A LIDIA G V FAYINY P G C | 2010 | Bioresource Technology2010，101，10： | 1 |
| 10 | Risk factors for thrombosis and primary thrombosis prevention in patients with systemic lupus erythematosus with or without antiphospholipid antibodies显示文摘 | Maria G T Katerina L Demosthenes B | | 0，，01： | 1 |
| 11 | Capillary e- lectrophoresis of free fatty acids by Indirect ultraviolet detection: application to the classification of vegetable oils according to their botanical origin显示文摘 | Maria V B Aar6n E D Jests L G M | 2011 | Food Chem- istry2011，59，10： | 1 |
| 12 | Topography of EEG multivariate phase synchronization in early Alzheimer' s disease 显示文摘 | Maria G K Mahdi J Andrea B | 2010 | Neurobiology of Aging2010，31，1： | 1 |
| 13 | Characterisation of low-fat high-dietary fibre frankfurters显示文摘 | NURIA G M MARIA 1 A A OLGA M B | 1999 | Meat Science1999，52，： | 1 |
| 14 | A high-frequency (95 GHz) electron paramagnctic resonance study of B-doped Ti02 photocatalysts显示文摘 | MARIA F A VALENTINA G B TIZIANO M B PAOLO F | 2008 | Inorganica Chimica Acta2008，361，： | 1 |
| 15 | Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy显示文摘Diabetic retinopathy(DR)affects approximately one-third of diabetic patients and,if left untreated,progresses to proliferative DR(PDR)with associated vitreous hemorrhage,retinal detachment,iris neovascularization,glaucoma and irreversible blindness.In vitreous samples of human patients with PDR,we found elevated levels of hypoxia inducible factor 1 alpha(HIF1α).HIFs are transcription factors that promote hypoxia adaptation and have important functional roles in a wide range of ischemic and inflammatory diseases.To recreate the human PDR phenotype for a preclinical animal model,we generated a mouse with neuroretinal-specific loss of the von Hippel Lindau tumor suppressor protein,a protein that targets HIF1αfor ubiquitination.We found that the neuroretinal cells in these mice overexpressed HIF1αand developed severe,irreversible ischemic retinopathy that has features of human PDR.Rapid progression of retinopathy in these mutant mice should facilitate the evaluation of therapeutic agents for ischemic and inflammatory blinding disorders.In addition,this model system can be used to manipulate the modulation of the hypoxia signaling pathways,for the treatment of non-ocular ischemic and inflammatory disorders. | Katherine J Wert Vinit B Mahajan Lijuan Zhang Yuanqing Yan Yao Li Joaquin Tosi Chun Wei Hsu Takayuki Nagasaki Kerstin M Janisch Maria B Grant MaryAnn Mahajan Alexander G Bassuk Stephen H Tsang | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 1 |
| 16 | Isolation, structural features and theological properties of water-extractable β- glucans from different Greek barley cultivars 显示文摘 | Maria I Costas G B Maria S I | 2004 | Journal of the Science of Food and Agriculture2004，，84： | 1 |
| 17 | Statistical characteristics of portal images and their influence in noise reduction 显示文摘 | ANTONIO G MARIA C B JORGE L | 2013 | Lecture Notes in Computer Science2013，7930，1： | 1 |
| 18 | Direct Electrochemical Sensing and Detection of Natural Antioxidants and Antioxidant Capacity in Vitro Systems显示文摘 | Antonio J B Agustin G C Maria C G | 2007 | Electroanalysis2007，19，22： | 1 |
| 19 | Cougulation disorders in liver disease显示文摘 | Lucio A Maria A G Vincenzo B | 2002 | Swminars in liver disease2002，22，1： | 1 |
| 20 | Effectiveness of Mindful ness-Based Cognitive Therapy on the Quality of Life, Emotional Status,and CD4 Cell Count of Patients Aging with HIV Infection 显示文摘 | Marian G G Maria J F Xavier B | 2014 | AIDS Behav2014，18，4： | 1 |
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