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| 1 | Hematological disorders and pulmonary hypertension显示文摘Pulmonary hypertension(PH),a serious disorder with a high morbidity and mortality rate,is known to occur in a number of unrelated systemic diseases.Several hematological disorders such as sickle cell disease,thalassemia and myeloproliferative diseases develop PH which worsens the prognosis.Associated oxidant injury and vascular inflammation cause endothelial damage and dysfunction.Pulmonary vascular endothelial damage/dysfunction is an early event in PH resulting in the loss of vascular reactivity,activation of proliferative and antiapoptotic pathways leading to vascular remodeling,elevated pulmonary artery pressure,right ventricular hypertrophy and premature death.Hemolysis observed in hematological disorders leads to free hemoglobin which rapidly scavenges nitric oxide(NO),limiting its bioavailability,and leading to endothelial dysfunction.In addition,hemolysis releases arginase into the circulation which converts L-arginine to ornithine,thus bypassing NO production.Furthermore,treatments for hematological disorders such as immunosuppressive therapy,splenectomy,bone marrow transplantation,and radiation have been shown to contribute to the development of PH.Recent studies have shown deregulated iron homeostasis in patients with cardiopulmonary diseases including pulmonary arterial hypertension(PAH).Several studies have reported low iron levels in patients with idiopathic PAH,and iron deficiency is an important risk factor.This article reviews PH associated with hematological disorders and its mechanism:and iron homeostasis and its relevance to PH. | Rajamma Mathew Jing Huang Joseph M Wu John T Fallon Michael H Gewitz | 2016 | World Journal of Cardiology2016，8，12： | 6 |
| 2 | Efficacy and safety of liquid nitrogen cryotherapy for treatment of Barrett's esophagus显示文摘AIM To evaluate the efficacy and safety of liquid nitrogen cryotherapy as a primary or rescue treatment for BE,with and without dysplasia,or intramucosal adenocarcinoma (IMC).METHODS This was a retrospective,single-center study carried out in a tertiary care center including 45 patients with BE who was treatment-na?ve or who had persistent intestinal metaplasia(IM),dysplasia,or IMC despite prior therapy.Barrett's mucosa was resected via EMR when clinically appropriate,then patients underwent cryotherapy until eradication or until deemed to have failed treatment.Surveillance biopsies were taken at standard intervals.RESULTS From 2010 through 2014,33 patients were studied regarding the efficacy of cryotherapy.Overall,29 patients (88%) responded to cryotherapy,with 84% having complete regression of all dysplasia and cancer.Complete eradication of cancer and dysplasia was seen in 75% of subjects with IMC; the remaining two subjects did not respond to cryotherapy.Following cryotherapy,15 patients with high-grade dysplasia (HGD) had 30% complete regression,50% IM,and 7% low-grade dysplasia (LGD); one subject had persistent HGD.Complete eradication of dysplasia occurred in all 5 patients with LGD.In 5 patients with IM,complete regression occurred in 4,and IM persisted in one.In 136 cryotherapy sessions amongst 45 patients,adverse events included chest pain (1%),stricture (4%),and one gastrointestinal bleed in a patient on dual antiplatelet therapy who had previously undergone EMR.CONCLUSION Cryotherapy is an efficacious and safe treatment modality for Barrett's esophagus with and without dysplasia or intramucosal adenocarcinoma. | Kristen Suchniak-Mussari Charles E Dye Matthew T Moyer Abraham Mathew Thomas J McGarrity Eileen M Gagliardi Jennifer L Maranki John M Levenick | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，9： | 4 |
| 3 | 显示文摘 | Mathews T Manoravi P Antony M P | 2000 | Solid State Ionics2000，135，： | 1 |
| 4 | Improved insulin sensitivity and resistance to weight gain in mice null for the Ahsg gene 显示文摘 | Mathews S T Singh G P Ranalletta M | 2002 | Diabetes2002，51，8： | 1 |
| 5 | Factors influencing the careseeking behaviour of chest symptomatics: a community-based study involving rural and urban population in Tamil Nadu, South India 显示文摘 | Sudha G Nirupa C Rajasakthivel M Sivasusbramanian S Sundaram V Bhatt S Subramaniam K Thiruvalluvan E Mathew R Renu G Santhal T | 2003 | Tropical Medicine and International Health2003，8，4： | 1 |
| 6 | Brain selenium accumulation in rat pups of selenium supplemented mothers 显示文摘 | Bou-Resli M N Mathew T C Dashti H M | 2002 | Anal Histol embryol2002，31，4： | 1 |
| 7 | Improved insulin sensitivity andresistance to weight gain in mice null for the Ahsg gene显示文摘 | Mathews S T Singh G P Ranalletta M | 2002 | Diabetes2002，51，8： | 1 |
| 8 | A novel approach for near-duplicate detection of web pages using TDW matrix 显示文摘 | Mathew M Shine N D Lakshmi T R | 2011 | International Journal of Computer Applications2011，19，7： | 1 |
| 9 | Fabrication of carbon encapsulated mono- and bimetallic (Sn and Sn/Sb Alloy) nanorodes: Potential lithium-ion battery anode materials 显示文摘 | LEE S H MATHEWS M HOSSE1N T | 2009 | The Journal of Physical Chemistry2009，21，11： | 1 |
| 10 | Annual summary of vital statistics :2008 显示文摘 | Mathews T J Minino A M Osterman M J | 2011 | Pediatrics2011，127，1： | 1 |
| 11 | Factors influencing the careseeking behaviour of chest symptomatics: a community-based study involving rural and urban population in Tamil Nadu, South India 显示文摘 | Sudha G Nirupa C Rajasakthivel M Sivasusbramanian S Sundaram V Bhatt S Subrananiam K Thiruvalluvan E Mathew R Renu G Santhal T | 2003 | Trop Med Int Health2003，8，4： | 1 |
| 12 | Clinical profile of cerebral venous thrombosis and the role of imaging in its diagnosis in patients with presumed idiopathic intraeranial hypertension 显示文摘 | Nithyanandam S Joseph M Mathew T | 2011 | Indian J Ophthalmo12011，59，2： | 1 |
| 13 | Comparison of creep rupture behaviour oftype 316L(N) austenitic stainless steel joints welded by TIG andactivated TIG welding processes显示文摘 | SAKTHIVEL T VASUDEVAN M LAHA K PARAMESWARAN P CHANDRAVATHI K S MATHEW MD BHADURI A K | 2011 | Materials Science andEngineering A2011，528，2223： | 1 |
| 14 | Clinical profile of cerebral venois thrombosis and the role of imaging in its diagnosis in patients with presumed idiopathic intracranial hypertension显示文摘 | Nithyanandam S Joseph M Mathew T | 2011 | Indian J Ophthalmol2011，59，2： | 1 |
| 15 | Pangelin, an antimycobacterial coumarin from Ducrosia anethifolia 显示文摘 | Stavri M Mathew K T Bucar F | 2003 | Planta Med2003，69，10： | 1 |
| 16 | Bovinefetuin is an inhibitor of insulin receptor tyrosinekinase显示文摘 | Mathews S T Srinivas P R Leon M A | 1997 | Life Sci1997，61，16： | 1 |
| 17 | Media violence exposure and frontal lobe activation measured by functional mag- netic resonance imaging in aggressive and nonaggres- sive adolescents 显示文摘 | Mathews V P Kronenberger W G Wang Y Lurito J T Lowe M J Dunn D W | 2005 | J Comput Assist Tomo2005，29，： | 1 |
| 18 | Liquid-phase veratrole acylation and toluene alkylation over WOx/ZrO2 solid acid catalysts 显示文摘 | Bordoloi A Mathew N T Devassy B M | 2005 | Journal of Molecular Catalysis A: Chemical2005，247，12： | 1 |
| 19 | Microstructural im- aging and characterization of the mechanical,chemical, thermal, and swelling properties of starch-chitosan blend films显示文摘 | Mathew S Brahmakumar M Abraham T E | 2006 | Bio- polymers2006，82，2： | 1 |
| 20 | Effect of reduced dietary sodium and blood pressure 显示文摘 | MIDGLEY T P BCH B M MATHEW A G | 1996 | JAMA1996，275，20： | 1 |
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