|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial显示文摘AIM To evaluate the effect of sitagliptin vs placebo on histologic and non-histologic parameters of nonalcoholic steatohepatitis(NASH).METHODS Twelve patients with biopsy-proven NASH were randomized to sitagliptin(100 mg daily)(n=6)or placebo(n=6)for 24 wk.The primary outcome was improvement in liver fibrosis after 24 wk.Secondary outcomes included evaluation of changes in NAFLD activity score(NAS),individual components of NAS(hepatocyte ballooning,lobular inflammation,and steatosis),glycemic control and insulin resistance[including measurements of glycated hemoglobin(Hb A1C)and adipocytokines],lipid profile including free fatty acids,adipose distribution measured using magnetic resonance imaging(MRI),and thrombosis markers(platelet aggregation and plasminogen activator inhibitor 1 levels).We also sought to determine the correlation between changes in hepatic fat fraction(%)[as measured using the Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation(IDEAL)MRI technique]and changes in hepatic steatosis on liver biopsy.RESULTS Sitagliptin was not significantly better than placebo at reducing liver fibrosis score as measured on liver biopsy(mean difference between sitagliptin and placebo arms,0.40,P=0.82).There were no significant improvements evident with the use of sitagliptin vs placebo for the secondary histologic outcomes of NAS total score as well as for the individual components of NAS.Compared to baseline,those patients who received sitagliptin demonstrated improved Hb A1C(6.7%±0.4%vs 7.9%±1.0%,P=0.02),and trended towards improved adiponectin levels(4.7±3.5μg/m L vs 3.9±2.7μg/m L,P=0.06)and triglyceride levels(1.26±0.43 mmol/L vs 2.80±1.64 mmol/L,P=0.08).However,when compared with placebo,sitagliptin did not cause a statistically significant improvement in Hb A1C(mean difference,-0.7%,P=0.19)nor triglyceride levels(mean difference-1.10mmol/L,P=0.19)but did trend towards improved adiponectin levels only(mean difference,0.60μg/m L,P=0.095).No significant changes in anthropometrics,liver enzymes,other adipocytokines,lipid profile,thrombosis parameters,or adipose distribution were demonstrated.The MRI IDEAL procedure correlated well with steatosis scores obtained on liver biopsy in both groups at baseline and post-treatment,and the Spearman correlation coefficients ranged from r=0.819(baseline)to r=0.878(post-treatment),P=0.002.CONCLUSION Sitagliptin does not improve fibrosis score or NAS after 24 wk of therapy.The MRI IDEAL technique may be useful for non-invasive measurement of hepatic steatosis. | Tisha R Joy Charles A McKenzie Rommel G Tirona Kelly Summers Shannon Seney Subrata Chakrabarti Neel Malhotra Melanie D Beaton | 2017 | World Journal of Gastroenterology2017，23，1： | 18 |
| 2 | Dual color optogenetic control of neural populations using low-noise,multishank optoelectrodes显示文摘Optogenetics allows for optical manipulation of neuronal activity and has been increasingly combined with intracellular and extracellular electrophysiological recordings.Genetically-identified classes of neurons are optically manipulated,though the versatility of optogenetics would be increased if independent control of distinct neural populations could be achieved on a sufficient spatial and temporal resolution.We report a scalable multisite optoelectrode design that allows simultaneous optogenetic control of two spatially intermingled neuronal populations in vivo.We describe the design,fabrication,and assembly of low-noise,multisite/multicolor optoelectrodes.Each shank of the four-shank assembly is monolithically integrated with 8 recording sites and a dualcolor waveguide mixer with a 7×30μm cross-section,coupled to 405 nm and 635 nm injection laser diodes(ILDs)via gradient-index(GRIN)lenses to meet optical and thermal design requirements.To better understand noise on the recording channels generated during diode-based activation,we developed a lumped-circuit modeling approach for EMI coupling mechanisms and used it to limit artifacts to amplitudes under 100μV upto an optical output power of 450μW.We implanted the packaged devices into the CA1 pyramidal layer of awake mice,expressing Channelrhodopsin-2 in pyramidal cells and ChrimsonR in paravalbumin-expressing interneurons,and achieved optical excitation of each cell type using sub-mW illumination.We highlight the potential use of this technology for functional dissection of neural circuits. | Komal Kampasi Daniel F.English John Seymour Eran Stark Sam McKenzie Mihály Vöröslakos György Buzsáki Kensall D.Wise Euisik Yoon | 2018 | Microsystems & Nanoengineering2018，4，1： | 8 |
| 3 | Electrodeless plasma thrusters for spacecraft: a review显示文摘The physics of electrodeless electric thrusters that use directed plasma to propel spacecraft without employing electrodes subject to plasma erosion is reviewed. Electrodeless plasma thrusters are potentially more durable than presently deployed thrusters that use electrodes such as gridded ion,Hall thrusters, arcjets and resistojets. Like other plasma thrusters, electrodeless thrusters have the advantage of reduced fuel mass compared to chemical thrusters that produce the same thrust. The status of electrodeless plasma thrusters that could be used in communications satellites and in spacecraft for interplanetary missions is examined. Electrodeless thrusters under development or planned for deployment include devices that use a rotating magnetic field; devices that use a rotating electric field; pulsed inductive devices that exploit the Lorentz force on an induced current loop in a plasma; devices that use radiofrequency fields to heat plasmas and have magnetic nozzles to accelerate the hot plasma and other devices that exploit the Lorentz force. Using metrics of specific impulse and thrust efficiency, we find that the most promising designs are those that use Lorentz forces directly to expel plasma and those that use magnetic nozzles to accelerate plasma. | S N BATHGATE M M M BILEK D R MCKENZIE | 2017 | Plasma Science and Technology2017，19，8： | 6 |
| 4 | Effective tumor immunotherapy directed against an oncogene-encoded produce using a vaccinia virus vector显示文摘 | Destree A McKenzies | 1987 | Proc Natl Acad Sci USA1987，84，19： | 1 |
| 5 | The surface charge on manganese dioxides显示文摘 | McKenzie R M | 1981 | Aust J Soil Res1981，19，： | 1 |
| 6 | Chang: in ultraviolet radiation reaching the earth's surface 显示文摘 | Madronieh S Mckenzie R L Caldwell M M | 1995 | AMBIO1995，24，： | 1 |
| 7 | Cloud coverage based on all-sky imaging and its impact on surface solar irradianee 显示文摘 | Pfister G McKenzie R L Liley J B | 2003 | Journal of Applied Meteorology2003，42，10： | 1 |
| 8 | Beta-NMR mea- surements of lithium ion transport in thin films of pure and lith- ium-salt-doped poly (ethylene oxide) 显示文摘 | MCKENZIE t HARADA M KIEFL R F | 2014 | Journal of the American Chemical Society2014，136，22： | 1 |
| 9 | Changes in biologically-active ultraviolet radiation reaching the Earth's surface 显示文摘 | McKenzie R L Aucamp P J Bais A F | 2007 | Photochemical and Photobiological Sciences2007，6，3： | 1 |
| 10 | Automated cell colony counting and analysis using the circular Hough image transform algorithm(CHiTA) 显示文摘 | Bewes J M Suchowerska N McKenzie D R | 2008 | Physics in Medicine and Biology2008，53，21： | 1 |
| 11 | Combined antioxidant treatment effects on blood oxidative stress after eccentric exercise显示文摘 | GOLDFARB A H BOLLMER R J MCKENZIE M J | 2005 | Med Sci Sports Exe2005，37，2： | 1 |
| 12 | Size dependent elemental composition of road-associated particles 显示文摘 | McKenzie E R Wong C M Green P G | 2008 | Science of the Total Enviromnent2008，398，： | 1 |
| 13 | Selenium in the immune system显示文摘 | ARTHUR J R McKENZIE R C BECKETT G J | 2003 | J Nutr2003，133，5： | 1 |
| 14 | Partial melt distributions from inversion of rare earth element concentrations显示文摘 | McKenzie D O'Nions R K | 1991 | J Petrol1991，32，5： | 1 |
| 15 | Cytologic features of metastatic and recurrent melanoma in patients with primary cutaneous desmoplastic melanoma显示文摘 | Murali R Loughman NT McKenzie PR | 2008 | Am J Clin Pathol2008，130，5： | 1 |
| 16 | Relation between FIGO stage,primary tumor volume,and presence of lymph node metastases in cervical cancer patients referred for radiotherapy显示文摘 | Narayan K McKenzie A F Hicks R J | 2003 | Int J Gynecol Cancer2003，13，5： | 1 |
| 17 | Anatomical study of the obturator forarnen and dorsal nerve of the clitoris and their relationship to minimally invasive slings 显示文摘 | Achtari C Mckenzie B J Hiscock R | 2006 | Int Urogyneco! J Pelvic Floor Dysfunct2006，17，4： | 1 |
| 18 | The adsorption of lead and other heavy metals on oxides of manganese and iron 显示文摘 | MCKENZIE R M | 1980 | Aust J Soil Res1980，18，： | 1 |
| 19 | The host range of chronic wasting disease is altered on passage in ferrets显示文摘 | BartzJ C Marsh R F mckenzie D I | 1998 | Virology1998，251，2： | 1 |
| 20 | The source regions of ocean island basalts 显示文摘 | McKenzie D O'Nions R K | 1995 | JPetrol1995，36，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员