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| 1 | Comparing the Diagnostic Criteria for Gestational Diabetes Mellitus of World Health Organization 2013 with 1999 in Chinese Population显示文摘INTRODUCTION Gestational diabetes mellitus (GDM) was earlier defined as 'hyperglycemia first recognized during pregnancy' and has more recently been described by American Diabetes Association (ADA) (2012) as diabetes diagnosed during pregnancy that is not clearly overt diabetes.[1] The hyperglycemia and adverse pregnancy outcomes study (HAPO) demonstrated that the risk of adverse maternal,fetal,and neonatal outcomes continuously increase as a function of maternal glycemia at 24-28 weeks,even within ranges previously considered normal for pregnancy.[2] After reviewing the results of the HAPO study,many international diabetes study groups,including the International Association of Diabetes and Pregnancy Study Groups and ADA have adopted the 75 g oral glucose tolerance test (OGTT) at 24-28 weeks as a screening and diagnostic test and defined new cut-off values for GDM diagnosis.The Ministry of Health of China published the criteria for GDM,that is the same as the ADA criteria on July 1,2011.World Health Organization (WHO) has recommended the 75 g OGTT with different cut-offvalues as a diagnostic test since 1999,changed its recommendation on 2013.In Hongkong and Yunnan province in China,most hospital adopted the WHO 1999 criteria,nevertheless,there is no evidence of multicenter and large sample to show that the GDM population within the same ethnic group diagnosed by the new WHO criteria matches those diagnosed by the old one and consistency between the two criteria has not been reported.Thus,we conducted this study to analyze the two criteria in Chinese pregnant women. | Weiwei Zhu Huixia Yang Yumei Wei Zilian Wang Xuelan Li Hairong Wu Nan Li Meihua Zhang Xinghui Liu Hua Zhang Yunhui Wang Jianmin Niu Yujie Gan Liruo Zhong Yunfeng Wang Anil Kapur | 2015 | Chinese Medical Journal2015，，1： | 42 |
| 2 | Expression and functional analysis of the rice plasma-membrane intrinsic protein gene family显示文摘血浆膜内在的蛋白质(果仁) 是 aquaporins 的一个亚科越过膜启用水的快、控制的 translocation。在这研究,我们系统地从米饭识别了并且克隆十果仁基因。基于他们编码了的氨基酸序列的类似,这些米饭果仁基因被分类进二个组并且指定了为 OsPIP1-1 到 OsPIP1-3 和 OsPIP2-1 到在玉米跟随果仁基因的名称的 OsPIP2-7。量的 RT-PCR 分析识别了三根特定并且一叶特定的 OsPIP 基因。而且,响应盐,干旱和骆驼毛的织物处理的每 OsPIP 基因的表示侧面详细被检验。OsPIP1 (OsPIP1-1 ) 或在野类型的 Arabidopsis,腌,然而并非腌更高的集中(NaCl 的 150 公里) 的处理的显示出的提高的忍耐(NaCl 的 100 公里) 和干旱(甘露糖醇的 200 公里) 的 OsPIP2 (OsPIP2-2 ) 过去表示的转基因的植物上的分析。总起来说,这些数据响应不同压力建议每 OsPIP 基因的一个不同角色,并且应该把新层加到米饭果仁基因的生理的功能的理解。 | Lei Guo Zi Yi Wang Hong Lin Wei Er Cui Jun Chen Meihua Liu Zhang Liang Chen Li Jia Qu Hongya Gu | 2006 | Cell Research2006，16，3： | 35 |
| 3 | Volcanism at the Permian-Triassic Boundary in South China and Its Effects on Mass Extinction显示文摘This paper discusses the clayrocks widespread at the Permian-Triassic boundary, which are mostly of volcanic origin. Volcanogenetic textures, structures and minerals such as high-temperature quartz are found in clayrocks at the Permian-Triassic boundary in many places. Thousands of microspherules have been collected from the Boundary clayrocks, many of which exhibit the typical features of the process from melting to cooling and solidification. indicating that they were formed by volcanic eruption or extraterrestrial impact. Volcanic effects on the Permian-Triassic mass extinction may be reflected in conodonts, algae and ammonoids. The Boundary clayrocks are found in many Permian-Triassic sections along the coast of Tethys. Their orighin remains to be studied. | Yin Hongfu, Huang Siji, Zhang Kexin, Yang Fengqing, Ding Meihua, Bi Xianmei and Zhang Suxin China University of Geosciences, Wuhan, Hubei | 1989 | Acta Geologica Sinica(English Edition)1989，63，4： | 22 |
| 4 | Apoptotic mechanism of MCF-7 breast cells in vivo and in vitro induced by photodynamic therapy with C-phycocyanin显示文摘这研究的目的是调查 C-phycocyanin (CPC ) 的 pro-apoptotic 机制在一个鼠科的肿瘤模型和有教养的 MCF-7 房间的调停的光力学的治疗(太平洋夏季时间) 。老鼠被划分成四个组:控制, HeNe 激光放射, CPC 处理,和 CPC 处理 + HeNe 激光放射。有免疫力的机关, immunocyte 增长,肿瘤开始,和 apoptosis 相关的蛋白质表情上的 CPC 或激光的效果被 immunohistochemistry 调查,在 situ 杂交, MTT,电子显微镜,西方的污点,和 immunofluorescence 试金。结果证明 HeNe 激光处理独自显示出边缘的效果。在 C-PC-treated 老鼠,有免疫力的机关的重量, immunocytes 的增长,和 pro-apoptotic 的表示,船边交货蛋白质被增加,而肿瘤重量和 anti-apoptotic 蛋白质(NF-B 和 P53 ) 和 CD44 mRNA 的表情比较地被减少。在 vitro, CPC 能包括 microvilli 损失,膜水泡的形成,和染色质冷凝作用禁止 MCF-7 房间增长和原因 ultrastructural 变化。而且, CPC 处理能激活 caspase-9 表示,导致细胞色素 c 版本,和 downregulate Bcl-2 表示。当与 HeNe 激光照耀结合了时, CPC 处理的效果进一步被提高。便于 apoptosis 信号 transduction 并且最后导致 MCF-7 房间的 apoptosis 可以是 C-PC-mediated 太平洋夏季时间的反肿瘤活动的机制。 | Bing Li Xianming Chu Meihua Gao Wuxiu Li | 2010 | Acta Biochimica et Biophysica Sinica2010，42，1： | 22 |
| 5 | Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses显示文摘Macrophages are typically identified as classically activated(M1) macrophages and alternatively activated(M2) macrophages,which respectively exhibit pro-and anti-inflammatory phenotypes,and the balance between these two subtypes plays a critical role in the regulation of tissue inflammation,injury,and repair processes.Recent studies indicate that tissue cells and macrophages interact via the release of small extracellular vesicles(EVs) in processes where EVs released by stressed tissue cells can promote the activation and polarization of adjacent macrophages which can in turn release EVs and factors that can promote cell stress and tissue inflammation and injury and vice versa.This review discusses the roles of such EVs in resulating such interactions to influence tissue inflammation and injury in a number of acute and chronic inflammatory disease conditions,and the potential applications,advantage and concerns for using EV-based therapeutic approaches to treat such conditions,including their potential role of drug carriers for the treatment of infectious diseases. | Qian Hu Christopher J.Lyon Jesse K.Fletcher Wenfu Tang Meihua Wan Tony Y.Hu | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 22 |
| 6 | Three-dimensional Finite Element Analysis of the Mechanical Properties of Helical Thread Connection显示文摘Conventional analytical and numerical methods for the mechanical properties of helical threads are relied on many assumptions and approximations and thus hardly yield satisfied results. A parameterized 3D finite element model of bolted joints with real helical thread geometry is established and meshed with refined hexahedral elements. The Von Mises plasticity criterion, kinematic hardening rule of materials and interfacial contacts are employed to make it possible for the suggested model be able to approach real assembly conditions. Then, the mechanical properties of bolted joints with different thread pitches, thread numbers and modular ratios are investigated, including the contact pressure distribution at joint interfaces, the axial load distribution and stress concentration in screw threads during the loading and unloading process. Simulation results indicate that the load distribution in screw threads produced by the suggested model agrees well the results from CHEN's photoelastic tests. In addition, an interesting phenomenon is found that tightening the bolt with a large preload first and then adjusting the clamping force by unloading can make the load distribution more uniform and reduce the maximum residual equivalent stress in thread roots by up to 40%. This research provides a simple and practical approach to constructing the 3D finite element model and predicting the mechanical properties of helical thread connection. | YANG Guoqing HONG Jun ZHU Linbo LI Baotong XIONG Meihua WANG Fei | 2013 | Chinese Journal of Mechanical Engineering2013，26，3： | 19 |
| 7 | Safety issues and new rapid detection methods in traditional Chinese medicinal materials显示文摘The safety of traditional Chinese medicine(TCM) is a major strategic issue that involves human health. With the continuous improvement in disease prevention and treatment, the export of TCM and its related products has increased dramatically in China. However, the frequent safety issues of Chinese medicine have become the ‘bottleneck' impeding the modernization of TCM. It was proved that mycotoxins seriously affect TCM safety; the pesticide residues of TCM are a key problem in TCM international trade; adulterants have also been detected, which is related to market circulation. These three factors have greatly affected TCM safety. In this study, fast, highly effective, economically-feasible and accurate detection methods concerning TCM safety issues were reviewed, especially on the authenticity, mycotoxins and pesticide residues of medicinal materials. | Lili Wang Weijun Kong Meihua Yang Jianping Han Shilin Chen | 2015 | Acta Pharmaceutica Sinica B2015，5，1： | 18 |
| 8 | Surface latent heat flux anomalies prior to the Indonesia Mw9.0 ear thquakeof 2004显示文摘The temporal and spatial variations of surface latent heat flux (SLHF) before and after the Mw9.0 earthquake that occurred on the west coast of Sumatra, Indonesia on 26 December 2004 are summarized. It is found that before the earthquake significant SLHF anomalies occurred at the epicentral area and its vicinity. The largest SLHF anomaly oc- curred on the subduction zone in the middle part of Burma micro-plate, where the middle part of the rup- ture zone is located and the aftershocks are concen- trated. The developments of the anomaly involved growing of the anomaly from small to large and spreading of the anomaly from disordered to con- centrated. The anomaly began to occur on the east extensional boundary of the Burma micro-plate and its adjacent oceanic basin, and then propagated to the west compressive boundary, where the subduc- tion zone exists. Finally, the anomaly disappeared after the main shock. The seismic source is consid- ered to be a dissipation system. The increase of stress prior to an earthquake may enhance the ex- change of energy and material between the seismic source system and the outer system, resulting in the increase of the rate of energy exchange between sea surface and atmosphere, which is believed to be the main reason of the generation of SLHF anomaly. | CHEN Meihua DENG Zhihui YANG Zhuzhuan MA Xiaojing | 2006 | Chinese Science Bulletin2006，51，8： | 14 |
| 9 | Major Depressive Disorder: Advances in Neuroscience Research and Translational Applications显示文摘Major depressive disorder(MDD),also referred to as depression,is one of the most common psychiatric disorders with a high economic burden.The etiology of depression is still not clear,but it is generally believed that MDD is a multifactorial disease caused by the interaction of social,psychological,and biological aspects.Therefore,there is no exact pathological theory that can independently explain its pathogenesis,involving genetics,neurobiology,and neuroimaging.At present,there are many treatment measures for patients with depression,including drug therapy,psychotherapy,and neuromodulation technology.In recent years,great progress has been made in the development of new antidepressants,some of which have been applied in the clinic.This article mainly reviews the research progress,pathogenesis,and treatment of MDD. | Zezhi Li Meihua Ruan Jun Chen Yiru Fang | 2021 | Neuroscience Bulletin2021，37，6： | 13 |
| 10 | CD59 Silencing via Retrovirus-Mediated RNA Interference Enhanced Complement-Mediated Cell Damage in Ovary Cancer显示文摘CD59,belonging to membrane complement regulatory proteins(mCRPs) ,inhibits the cytolytic activity of complement and is over-expressed in solid cancers,including ovary cancer. The aim of the present study was to construct recombinant retrovirus encoding shRNA targeted human CD59 and infect A2780 cells in order to investigate the relationship between decreased CD59 expression and tumorigenesis of ovary cancer. siCD59 and siCD59-C were successfully constructed and identified by PCR,restriction endonuclease analyses and DNA sequencing,respectively. The siCD59 was able to efficiently infect A2780 cells,which was confirmed by Western blotting. When incubated with fresh normal human serum(8%,v/v) for 1 h at 37°C,the cell viability was decreased and cell damage was increased in siCD59 infected A2780 cells compared to siCD59-C infected cells. This led to the activation of caspase-3. The apoptosis in siCD59 infected cells was shown with hypercondensed nuclei using Hoechst staining. Meanwhile,the weight of ovary tumor graft in nude mice was significantly decreased in siCD59 group compared to that of siCD59-C group. And the expression of CD59 protein in tumor tissue in siCD59 group was significantly decreased. These results suggested that CD59 silencing in ovary cancer cells via retrovirusmediated RNAi can enhance complement-mediated cell damage,inhibiting growth of ovary cancer. CD59 might be a potential target for gene therapy in ovary cancer. | Xuexiang Shi Bei Zhang Jinlin Zang Guoying Wang Meihua Gao | 2009 | Cellular & Molecular Immunology2009，6，1： | 12 |
| 11 | Unruptured pregnancy in a noncommunicating rudimentary horn at37 weeks with a live fetus:a case report显示文摘We report an extremely rare case of an unruptured non-communicating rudimentary horn full-term pregnancy.A woman who had a uterine malformation was misdiagnosed as uterus didelphys and gave birth to a live,healthy fetus.The correct diagnosis was not made until cesarean section at 37 4/7 weeks.The case suggests that women who are pregnant in a rudimentary horn could obtain a full-term delivery and give birth to a live and healthy baby. | Chen Cheng Weiwei Tang Lei Zhang Mei Luo Meihua Huang Xiuling Wu Guiping Wan | 2015 | The Journal of Biomedical Research2015，29，1： | 11 |
| 12 | A Novel Approach to Automatic Security Protocol Analysis Based on Authentication Event Logic显示文摘Since security protocols form the cornerstones of modern secure networked systems, it is important to develop informative, accurate, and deployable approach for finding errors and proving that protocols meet their security requirements. We propose a novel approach to check security properties of cryptographic protocols using authentication event logic. Compared with logic of algorithm knowledge, authentication event logic guarantees that any well-typed protocol is robustly safe under attack while reasoning only about the actions of honest principals in the protocol. It puts no bound on the size of the principal and requires no state space enumeration and it is decidable. The types for protocol data provide some intuitive explanation of how the protocol works. Our approach has led us to the independent rediscovery of flaws in existing protocols and to the design of improved protocols. | XIAO Meihua MA Chenglin DENG Chunyan ZHU Ke | 2015 | Chinese Journal of Electronics2015，24，1： | 10 |
| 13 | Research on characters of surrounding rock in complex geology conditions and supporting time显示文摘The methods combined by test, field monitoring and theoretical analysis were adopted to do the systemic research on the rock mass from micro-structure to macro-deformation, and rheological model of Jinchuan rock mass was established to discuss the reasonable supporting time. Results show that supporting after suitable stress and displacement release can benefit for the long-term stability of surrounding rock. | Yu Weijian Gao Qian Zhai Shuhua Zhang Meihua | 2008 | Engineering Sciences2008，6，2： | 9 |
| 14 | Activity after Site-Directed Mutagenesis of CD59 on Complement-Mediated Cytolysis显示文摘CD59 may inhibit the cytolytic activity of complement by binding to C8/C9 and protect host cell membranes against homologous membrane attack complex (MAC). However,CD59 is widely overexpressed on tumor cells,which has been implicated in tumorigenesis. The active site of CD59 relative to MAC is still confused. As reported the MAC binding site is located in the vicinity of a hydrophobic groove on the membrane distal face of the protein centered around residue W40. Here two site-directed mutagenesis were performed by overlapping extension PCR to delete residue W40 site (Mutant 1,M1) or to change C39W40K41 to W39W40W41 (Mutant 2,M2). Then we constructed mutant CD59 eukaryotic expression system and investigated their biological function on CHO cells compared with wild-type CD59. Stable populations of CHO cells expressing recombinant proteins were screened by immunotechnique. After 30 passages culturing,proteins could be tested. Dye release assays suggest that M1CD59 loses the activity against complement,while M2CD59 increases the anti-complement activity slightly. Results indicate that W40 of human CD59 is important to its activity,and prohibition of this site may be a potential way to increase complement activity and to treat tumors. | Xinhong Zhu Meihua Gao Shurong Ren Qiubo Wang Cunzhi Lin | 2008 | Cellular & Molecular Immunology2008，5，2： | 8 |
| 15 | Assessment of meteorological disasters based on information diffusion theory in Xinjiang, Northwest China显示文摘洪水,干旱,下得很大的冰雹,和在从 1949 ~ 2012 的 Xinjiang 的低温度事件的数据与散开方法被分析在 Xinjiang 估计灾难的最普通的类型的风险。学习区域的气象学的灾难的频率和紧张显示出与全球温暖联系的一个增加的趋势,这被证明。在灾难的四种类型之中,超过干旱的概率最大,接着由下得很大的冰雹,低温度和洪水列在后面。而且,小浪方法分析表明自从 2000,更大的摆动发生了,它可以与极端气候的变化的出现被联系。频率的空间分发表明 Tianshan 山的北斜坡是一个多重灾区, Tianshan 的南部的斜坡是更多的洪水和下得很大的冰雹发生的区域,并且 Turpan-Hami 盆的西方是区域风是流行的。在影响灾难的区域和相应气象学、社会经济的索引之间的关系也被分析。它显示除了谷物面积,在影响的区域和最气象学、社会经济的指示物之间有重要积极关联。 | WU Meihua CHEN Yaning XU Changchun | 2015 | Journal of Geographical Sciences2015，25，1： | 7 |
| 16 | SYNTHESIS AND FLOCCULABILITY OF SODIUM ALGINATE GRAFTED WITH ACRYLAMIDE显示文摘Graft copolymers of sodium alginate (SA) with acrylamide (AM) were synthesized using a ceric ion initiated solution polymerization technique. The acrylamide conversions were studied by changing reaction conditions, such as temperature, molecular weight of sodium alginate and reaction time. The flocculation performance of the graft copolymer (SAG) was investigated in kaolin suspension and also in dyeing waste water. It was found that SAG is more efficient in flocculation behavior as compared to polyacrylamide and SA in kaolin suspension, and in removal capacities for CODCr and colority in dyeing wastewater. | Kaiqiang Xu Xiongli Xu Zhiji Ding Meihua Zhou | 2006 | China Particuology2006，4，2： | 7 |
| 17 | Studies of Primary Angle Qosure Glaucoma in China显示文摘The resent researches on primary angle closure glaucoma (PACG) in China were reviewed. The prevalence of PACG (0.41%) in chinese is between the Caucasian and Eskimos, and chronic type is the dominant type in PACG. However, with the economic development and medical care improvements, the prevalence condition of PACG may change; several researches discovered that the mechanism of PACG, especially the chronic type, is not only because of pupil-blocking but also closely related to the mechanism of crowding of peripheral iris and the anterior location of the ciliary body. We supposed that PACG can be divided into several subtypes based on this machnism. Also, we believe that the use of ultrasound biomicroscopy (UBM) and ophthalmic laser in China has promoted the research of PACG and improved the level of prevention and treatment of PACG. Eye Science 1997; 13 : 120- 124. | Ningli Wang, Wenbin Zhou, Tiancai Ye, Qiang Yu, Mingying Lai, Meihua LeZhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China | 1997 | 眼科学报1997，13，3： | 7 |
| 18 | 延边地区乳腺癌中Ki-67、COX-2和p53的表达及意义显示文摘[目的]探讨乳腺癌中Ki-67、COX-2和p53表达及意义。[方法]应用免疫组化方法检测51例乳腺癌中Ki-67、COX-2、p53、ER、PR和C-erb B-2的表达情况,并分析其与乳腺癌临床病理特征的关系。[结果](1)乳腺癌中Ki-67、COX-2和p53的阳性表达率分别为70.6%(36/51)、64.7%(33/51)和66.7%(34/51);C-erb B-2、ER和PR的阳性表达率分别为23.5%(12/51),70.6%(36/51)和74.5%(38/51)。(2)Ki-67、COX-2和p53的表达与乳腺癌患者年龄、肿瘤大小、临床分期和病理类型无关,与淋巴结转移有关(P均<0.05)。(3)Ki-67、COX-2、p53表达与ER、PR水平呈负相关,而与C-erb B-2水平呈正相关。(4)COX-2与Ki-67及p53表达呈正相关。[结论]Ki-67、COX-2和p53的在乳腺中高表达,可能与乳腺癌的发生发展有关。 | 朴美慈 MEIHUA PIAO 全雄男 | 2015 | 中国肿瘤2015，24，2： | 7 |
| 19 | Deep-learning-based ciphertext-only attack on optical double random phase encryption显示文摘Optical cryptanalysis is essential to the further investigation of more secure optical cryptosystems.Learning-based at-tack of optical encryption eliminates the need for the retrieval of random phase keys of optical encryption systems but it is limited for practical applications since it requires a large set of plaintext-ciphertext pairs for the cryptosystem to be at-tacked.Here,we propose a two-step deep learning strategy for ciphertext-only attack(COA)on the classical double ran-dom phase encryption(DRPE).Specifically,we construct a virtual DRPE system to gather the training data.Besides,we divide the inverse problem in COA into two more specific inverse problems and employ two deep neural networks(DNNs)to respectively learn the removal of speckle noise in the autocorrelation domain and the de-correlation operation to retrieve the plaintext image.With these two trained DNNs at hand,we show that the plaintext can be predicted in real-time from an unknown ciphertext alone.The proposed learning-based COA method dispenses with not only the retrieval of random phase keys but also the invasive data acquisition of plaintext-ciphertext pairs in the DPRE system.Numerical simulations and optical experiments demonstrate the feasibility and effectiveness of the proposed learning-based COA method. | Meihua Liao Shanshan Zheng Shuixin Pan Dajiang Lu Wenqi He Guohai Situ Xiang Peng | 2021 | Opto-Electronic Advances2021，4，5： | 7 |
| 20 | Emodin attenuates severe acute pancreatitis-associated acute lung injury by suppressing pancreatic exosome-mediated alveolar macrophage activation显示文摘Severe acute pancreatitis-associated acute lung injury(SAP-ALI) is a serious disease associated with high mortality. Emodin has been applied to alleviate SAP-ALI;however, the mechanism remains unclear. We report that the therapeutic role of emodin in attenuating SAP-ALI is partly dependent on an exosomal mechanism. SAP rats had increased levels of plasma exosomes with altered protein contents compared to the sham rats. These infused plasma exosomes tended to accumulate in the lungs and promoted the hyper-activation of alveolar macrophages and inflammatory damage. Conversely,emodin treatment decreased the plasma/pancreatic exosome levels in the SAP rats. Emodin-primed exosomes showed less pro-inflammatory effects in alveolar macrophages and lung tissues than SAP exosomes. In detail, emodin-primed exosomes suppressed the NF-κB pathway to reduce the activation of alveolar macrophage and ameliorate lung inflammation by regulating PPARγ pathway, while these effects were amplified/abolished by PPARγ agonist/antagonist. Blockage of pancreatic acinar cell exosome biogenesis also exhibited suppression of alveolar macrophage activation and reduction of lung inflammation. This study suggests a vital role of exosomes in participating inflammation-associated organ-injury,and indicates emodin can attenuate SAP-ALI by reducing the pancreatic exosome-mediated alveolar macrophage activation. | Qian Hu Jiaqi Yao Xiajia Wu Juan Li Guixiang Li Wenfu Tang Jingping Liu Meihua Wan | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 7 |
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