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| 1 | Placental accommodations for transport and metabolism during intra-uterine crowding in pigs显示文摘Litter size and birth weights are limited by uterine capacity, defined as the ability of the uterus to maintain the appropriate development of some number of conceptuses. Uterine capacity is the result of the combined effects of uterine, placental and embryo/fetal function. The number of living conceptuses that the uterus is capable of supporting is greater during early gestation compared to later gestation. Plots of log fetal weight versus log placental weight also indicate that fetal weights are less sensitive to reduced placental weight(and therefore reduced intrauterine space) in early gestation compared to late gestation. However, even in late gestation,mechanisms still exist that maintain fetal growth when the size of the placenta is reduced. One such mechanism is likely to be improved development of the folded placental-epithelial/maternal-epithelial bilayer. Fold depth, and therefore the maternal fetal interactive surface, increases as gestation advances and is greater in placenta from small fetuses. On the fetal side of the placenta, the epithelial bilayer is embedded in stromal tissue. Glycosaminoglycans are major components of stroma, including hyaluronan and heparan sulfate. Hyaluronidases and heparanases are present within placental tissues, and likely play roles in modification of stromal components to facilitate fold development. Glycosaminoglycans are polymers of forms of glucose(glucosamine, glucuronic acid, iduronic acid)suggesting that glycosaminoglycan synthesis may compete with the glucose needs of the developing fetus.Pig conceptuses are fructogenic, such that a substantial portion of glucose transferred from mother to fetus is converted to fructose. Fructose is an intermediate product in the synthesis of glucosamine from glucose, and glucosamine is linked to regulation of trophoblast cell proliferation through regulation of m TOR. These findings suggest a link between glucose, fructose, glucosamine synthesis, GAG production, and placental morphogenesis,but the details of these interactions remain unclear. In addition, recent placental epithelial transcriptome analysis identified several glucose, amino acid, lipid, vitamin, mineral and hormone transporter mechanisms within the placenta. Further elucidation of mechanisms of placental morphogenesis and solute transport could provide clues to improving nutrient transport to the pig fetus, potentially increasing litter size and piglet birth weights. | Jeffrey L Vallet Anthony K Mc Neel Jeremy R Miles Bradley A Freking | 2015 | Journal of Animal Science and Biotechnology2015，6，2： | 5 |
| 2 | Polyconal antibodies to domoic acid, and their use in immunoassays for do moic acid in sea water and shellfish显示文摘 | GARTHWAITE I ROES K M MILES C O | 1998 | Nat Toxins1998，6，： | 1 |
| 3 | CT staging of renal carcinoma:a prospective comparison of three dynamic computed tomography techniques显示文摘 | Miles K A London N J M Lavelle J M | 1991 | Eur J Radiol1991，13，7： | 1 |
| 4 | Pumilio facilitates miRNA reg- ulation of the E2F3 oncogene显示文摘 | Miles WO Tschtip K Herr A | 2012 | Genes Dev2012，26，4： | 1 |
| 5 | Pediatric diffuse large B - cell lymphoma demonstrates a high proliferation index, frequent c - Myc protein expression, and a high incidence of germinal center subtype: Report of the French - American - British ( FAB ) international study group 显示文摘 | Miles RR Raphael M McCarthy K | 2008 | Pediatr Blood Cancer2008，51，3： | 1 |
| 6 | Chronic compartment syndrome affecting the lower limb:MIBI perfusion imaging as an alterative to pressure monitoring: two case reports 显示文摘 | Edwards P Miles K | 1999 | Br J Sports Med1999，33，1： | 1 |
| 7 | Perfusion C T: a worthwhile enhance- ment 显示文摘 | Miles K A Griffiths M R | 2003 | Br J Radio12003，76，904： | 1 |
| 8 | Functional computed tomography in oncology显示文摘 | Miles K A | 2002 | Eur J Cancer2002，38，16： | 1 |
| 9 | Perfusion CT: a worthwhile enhancement显示文摘 | Miles K A Griffiths M R | 2003 | Br J Radiol2003，76，2： | 1 |
| 10 | Combi- nation slralegy targeling VEGF and HGF/e-met in human renal cell carcinoma models显示文摘 | CIAMPORCERO E MILES K M ADELAIYE R | 2015 | Mol Cancer Ther2015，14，1： | 1 |
| 11 | Photovoltaie solar cells : an overview of state-of-the-art cell development and environmental issues 显示文摘 | MILES R W HYNES K M FORBES I | 2005 | Progress in Crystal Growth and Characterization of Materials2005，51，13： | 1 |
| 12 | Measurement of tissue perfusion by dy namic computed tomography 显示文摘 | MILES K A | 1991 | Br J Radiol1991，64，： | 1 |
| 13 | Coping style and depres- sion influence the healing of diabetic foot ulcers: observational and mechanistic evidence显示文摘 | Vedhara K Miles JN Wetherell MA | 2010 | Diabetologia2010，53，8： | 1 |
| 14 | Functional computed tomography in oncology显示文摘 | Miles K A | 2002 | Eur J Cancer2002，38，10： | 1 |
| 15 | Measurement of tissue perfusion by dynamic computed tomography显示文摘 | Miles K A | 1991 | Br J Radiol1991，64，761： | 1 |
| 16 | Meas urement of human pancreatic perfusion using dynamic computed tomography with perfusion imaging显示文摘 | MILES K A HAYBALL M P DIXON A K | 1995 | Radiol1995，68，： | 1 |
| 17 | Ideal contrast medi- umbolus for perfusion measurement in dynamic lung CT显示文摘 | Miles K A Blomley M Tsushima Y | 1998 | Ra- diology1998，209，2： | 1 |
| 18 | Pediatric diffuse large B-cell lymphoma demonstrates a high proliferation index,frequent C-myc protein expression,and a high incidence of germinal center subtype:Report of the French-American-British (FAB) international study group显示文摘 | Miles RR Raphael M McCarthy K | 2008 | Research Article2008，20，： | 1 |
| 19 | Attenuation of ultrasound in milk显示文摘 | Miles C Shore D Langley K R | 1990 | Ultrasonics1990，28，： | 1 |
| 20 | Photovoltaic solar cells: an overview of state-of-the-art cell development and environmental issues显示文摘 | MILES R W HYNES K M FORBES I | 2005 | Progress in Crystal Growth and Characterization of Materials2005，51，13： | 1 |
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