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| 1 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 2 | Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis显示文摘Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone.Biomineralization is regulated by the ratio of inorganic phosphate(Pi) to mineral inhibitor pyrophosphate(PPi), where local Piand PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase(TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1(NPP1). The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enpp1 null mouse increased acellular cementum, with little effect on cellular cementum.Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enpp1 gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPienvironment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPihave little effect on cellular cementum formation, though matrix mineralization is affected. | Laura E Zweifler Mudita K Patel Francisco H Nociti Jr Helen F Wimer Jose L Milln Martha J Somerman Brian L Foster | 2015 | International Journal of Oral Science2015，7，1： | 5 |
| 3 | Presbycusis显示文摘 | George A Gates John H Mills | 2005 | The Lancet . 2005 (9491)2005，，9491： | 2 |
| 4 | Calpain activity in the rat brain after transient forebrain ischemia 显示文摘 | NEUMAR R W MENG F H MILLS A M | 2001 | Exp Neurol2001，170，1： | 1 |
| 5 | Stepwise Refinement and Verification in Box-Structured Systems显示文摘 | | 1988 | IEEE Computer1988，21，： | 1 |
| 6 | Houdriforming reactions catalytic mechanism显示文摘 | MILLS G A HEINEMANN H MILLIKEN T H OBLAD A G | 1953 | Ind Eng Chem1953，45，： | 1 |
| 7 | The emerging role of lysophosphatidic acid in cancer 显示文摘 | Mills G B Moolenaar W H | 2003 | Nat Rev Cancer2003，3，8： | 1 |
| 8 | Benefit from endoscopicsinus surgery 显示文摘 | MEHANNA H MILLS J KELLY B | 2002 | Clin Otolaryngol2002，27，： | 1 |
| 9 | Collapse of a fish population after exposure to a synthetic estrogen 显示文摘 | KIDD K A BLANCHFIELD P J MILLS K H | 2007 | Pro- ceedings of the National Academy Science2007，104，21： | 1 |
| 10 | Heterogeneous Photopolymerization of Methyl Methacrylate Initiated by Small ZnO Parti- cles 显示文摘 | H uang Z Y Barber T Mills G | 1994 | J Phys Chem1994，98，12： | 1 |
| 11 | SNS-595, a naphthyridine cell cycle inhibitor and stimulator of apoptosis for the treatment of cancers显示文摘 | Mills D A Fekrazad H M Verschraegen C F | 2008 | Current Opinion in Investigational Drugs2008，9，6： | 1 |
| 12 | Effect of polymerization on particle morphology in heterogeneous systems显示文摘 | MILLS M F GIBERT R G NAPPER D H | 1990 | Macromolecules1990，，23： | 1 |
| 13 | Effects of deficit irrigation on fruit maturity and quality of 'Braeburn' apple 显示文摘 | Mpelasoka B S Behboudian M H Mills T M | 2001 | Scientia Horticulturea2001，90，： | 1 |
| 14 | Surface cracking in continuously cast products显示文摘 | Billany T J H Normanton A S Mills K C | 1991 | Ironmaking and Steelmaking1991，，6： | 1 |
| 15 | Elevated procalcitonin as a diagnostic marker in meningococcal disease显示文摘 | MILLS G D LALA H M OEHLEY M R | 2006 | Eur J Clin Micro- biol Infect Dis2006，25，： | 1 |
| 16 | Molecular properties of food allergens显示文摘 | BREITENEDER H MILLS E | 2005 | Journal of Allergy and Clinical Immunology2005，115，1： | 1 |
| 17 | A system for rapid genera- tion of coat color-tagged knockouts and defined chromosomal rearrangements in mice 显示文摘 | Zhang B H Mills A A Bradley A | 1999 | Nucleic Acids Res1999，27，： | 1 |
| 18 | Comparison of out- comes of laparoscopic versus open appendectomy in a- dults: data from the Nationwide Inpatient Sample (NIS) ,2006--2008显示文摘 | Masoomi H Mills S Dolich MO | 2011 | J Gastrointest Surg2011，15，12： | 1 |
| 19 | Urinary diversion 显示文摘 | World Health Organization (WHO) Conference in Bladder Cancer Hautmann RE Abol-Enein H Hafez K Haro I Mansson W Mills RD Montie JD Sagalowsky AI Stein JP Stenzl A Studer UE Volkmer BG | 2007 | Urology2007，，： | 1 |
| 20 | Human wayfinding, environment-behavior relationships, and artificial intelligence显示文摘 | Mille H J | 1992 | Journal of Planning Literature1992，7，2： | 1 |
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