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| 1 | Inflammatory bowel disease: An increased risk factor for neurologic complications显示文摘Only a very few systematic studies have investigated the frequency of neurologic disorders in patients with Crohn's disease(CD) and ulcerative colitis(UC), which are the two main types of inflammatory bowel disease(IBD). Results have been inconsistent and variable, owing to differences in case-finding methods and evaluated outcomes in different studies. The most frequent neurologic manifestations reported in CD and UC populations are cerebrovascular disease(with either arterial or venous events), demyelinating central nervous system disease, and peripheral neuropathy(whether axonal or demyelinating); however, the literature describes numerous nervous system disorders as being associated with IBD. The pathogenesis of nervous system tissue involvement in IBD has yet to be elucidated, although it seems to be related to immune mechanisms or prothrombotic states. The recently-introduced tumor necrosis factor(TNF) inhibitors have proven successful in controlling moderate to severe IBD activity. However, severe neurologic disorders associated with TNF inhibitors have been reported, which therefore raises concerns regarding the effect of anti-TNF-α antibodies on the nervous system. Although neurological involvement associated with IBD is rarely reported, gastroenterologists should be aware of the neurologic manifestations of IBD in order to provide early treatment, which is crucial for preventing major neurologic morbidity. | Germán Morís | 2014 | World Journal of Gastroenterology2014，20，5： | 3 |
| 2 | Congenital coronary artery anomalies with origin in the contralateral sinus of Valsalva:which approach should we take?显示文摘 | Morís de la Tassa C | 2006 | Rev Esp Cardiol2006，59，4： | 1 |
| 3 | Adult congenital anomalies of the coronary arteries described over 31 years of angiographic studies in the asturias principality:main angiographic and clinical characteristics显示文摘 | Barriales-Villa R Morís C López-Muniz A | 2001 | Rev Esp Cardiol2001，54，3： | 1 |
| 4 | Congenital coronary artery anomalies with origin in the contralateral sinus of Valsalva:which approach should we take显示文摘 | Barriales-Villa R Morís de la Tassa C | | 0，，04： | 1 |
| 5 | Solvent extraction of molybdenum and tungsten by Alamine336 and DEHPA显示文摘 | Coca J Díez F V Morís M A | 1990 | Hydrometallurgy1990，25，2： | 1 |
| 6 | Genetic and cytological evidence of hybridization between na-tive Ruditapes decussates and introduced Ruditapes phi-lippinarum (Mollusa,Bivalvia,Veneridae) in NW Spain 显示文摘 | Hurtado N S Pérez-García C Morán P | 2011 | Aquaculture2011，311，14： | 1 |
| 7 | The two leading hypothesis regarding the molecular mech-anisms and etiology of preeclampsia,and the Mexican ex-perience in the world context显示文摘 | Sánchez-Rodríguez EN Nava-Salazar S Morán C | 2010 | Rev Invest Clin2010，62，3： | 1 |
| 8 | Proteome profile changes during mouse testis development显示文摘 | María Paz Matías Morín Jesús del Mazo | 2006 | Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics2006，，4： | 1 |
| 9 | Adult congenital anomalies of the coronary arteries described over 31 years of angiographic studies in the asturias principality:main angiographic and clinical characteristics显示文摘 | Barriales Villa R Morís C López Mu?iz A | | 0，，03： | 1 |
| 10 | Photo-Fenton and sequencing batch reactor coupled to photo-Fenton processes for textile wastewater reclamation: Feasibility of reuse in dyeing processes显示文摘 | José Blanco Francesc Torrades Moisés Morón Marolda Brouta-Agnésa Julia García-Monta?o | 2013 | Chemical Engineering Journal2013，，： | 1 |
| 11 | Organophosphorous pesticide exposure alters sperm chromatin structure in Mexican agricultural workers显示文摘 | Sánchez-Pe(N)a LC Reyes BE López-Carrillo L Recio R Morán-Martínez J Cebrián ME | 2004 | Toxicol Appl Pharmacol2004，196，1： | 1 |
| 12 | Point-of-care ultrasonography in geriatric medicine: usefulness for approaching infectious endocarditis diagnosis显示文摘Infective endocarditis has a high morbimortality rate,and delay in diagnosis and treatment is associated with a higher prevalence of complications.The clinical presentation is often atypical in older adults,and even when the classic symptoms are present,they may overlap with those of other conditions,making management more difficult.We present the case of a nonagenarian in whom cardiac-centered point-of-care ultrasound facilitated real-time decision making and the diagnosis of mitral endocarditis. | Pablo Solla Patricia Cancelo Eva López Jesús de la Hera César Morís José Gutiérrez | 2022 | Journal of Geriatric Cardiology2022，19，12： | 0 |
| 13 | Abnormal electrocardiogram in a patient with amyotrophic lateral sclerosis mimicking myocardial ischaemia显示文摘Amyotrophic lateral sclerosis(ALS) is a progressive neurodegenerative disorder that almost exclusively involves motor neurons although autonomic dysfunction has also been reported. We present an 84-year-old female with no documented history of heart disease, who was admitted with negative T waves in the electrocardiogram precordial leads mimicking myocardial ischaemia. No other abnormalities were shown in the rest of the cardiologic evaluation, suggesting autonomic nervous system dysfunction. A neurophysiological study demonstrated acute and chronic denervation in multiple muscles with normal nerve conduction studies, confirming ALS diagnosis. Previous studies have shown that subclinical sympathetic hyperfunction and parasympathetic hypofunction might result in cardiovascular dysfunction in ALS patients. It is important to detect disturbances of autonomic cardiac control because this dysfunction may influence survival and quality of life, leading to a decrease in life expectancy in ALS patients.This Case Report may support the impairment of cardiac autonomic control in patients with ALS. | Juana Martínez César Ramón César Morís Julio Pascual Germán Morís | 2014 | World Journal of Clinical Cases2014，2，6： | 0 |
| 14 | Differential colorectal carcinogenesis:Molecular basis and clinical relevance显示文摘Colorectal cancer(CCR) is one of the most frequent cancers in developed countries.It poses a major public health problem and there is renewed interest in understanding the basic principles of the molecular biology of colorectal cancer.It has been established that sporadic CCRs can arise from at least two different carcinogenic pathways.The traditional pathway,also called the suppressor or chromosomal instability pathway,follows the Fearon and Vogelstein model and shows mutation in classical oncogenes and tumour suppressor genes,such as K-ras,adenomatous polyposis coli,deleted in colorectal cancer,or p53.Alterations in the Wnt pathway are also very common in this type of tumour.The second main colorectal carcinogenesis pathway is the mutator pathway.This pathway is present in nearly 15% of all cases of sporadic colorectal cancer.It is characterized by the presence of mutations in the microsatellite sequences caused by a defect in the DNA mismatch repair genes,mostly in hMLH1 or hMSH2.These two pathways have clear molecular differences,which will be reviewed in this article,but they also present distinct histopathological features.More strikingly,their clinical behaviours are completely different,having the 'mutator' tumours a better outcome than the 'suppressor' tumours. | Alberto Morán Paloma Ortega Carmen de Juan Tamara Fernández-Marcelo Cristina Frías Andrés Sánchez-Pernaute Antonio José Torres Eduardo Díaz-Rubio Pilar Iniesta Manuel Benito | 2010 | World Journal of Gastrointestinal Oncology2010，2，3： | 5 |
| 15 | Amino acid-based surfactants显示文摘 | María Rosa Infante Lourdes Pérez Aurora Pinazo Pere Clapés María Carmen Morán Marta Angelet María Teresa García María Pilar Vinardell | 2004 | Comptes rendus - Chimie2004，，6： | 1 |
| 16 | Performance of Drought Indices for Ecological, Agricultural, and Hydrological Applications显示文摘 | Vicente-Serrano Sergio M Beguería Santiago Lorenzo-Lacruz Jorge Camarero Jesús Julio López-Moreno Juan I Azorin-Molina Cesar Revuelto Jesús Morán-Tejeda Enrique Sanchez-Lorenzo Arturo | 2012 | EN2012，，10： | 1 |
| 17 | Prognostic value of ^(13)C-phenylalanine breath test on predicting survival in patients with chronic liver failure显示文摘AIM: To evaluate the prognostic value of percentage of 13C-phenylalanine oxidation (13C-PheOx) obtained by 13C-phenylalanine breath test (13C-PheBT) on the survival of patients with chronic liver failure. METHODS: The hepatic function was determined by standard liver blood tests and the percentage of 13C-PheOx in 118 chronic liver failure patients. The follow-up period was of 64 mo. Survival analysis was performed by the Kaplan-Meier method and variables that were significant (P < 0.10) in univariate analysis and subsequently introduced in a multivariate analysis according to the hazard model proposed by Cox. RESULTS: Forty-one patients died due to progressive liver failure during the follow-up period. The probability of survival at 12, 24, 36, 48 and 64 mo was 0.88, 0.78, 0.66, 0.57 and 0.19, respectively. Multivariate analysis demonstrated that Child-Pugh classes, age, creatinine and the percentage of 13C-PheOx (HR 0.338, 95% CI: 0.150-0.762, P = 0.009) were independent predictors of survival. When Child-Pugh classes were replaced by all the parameters of the score, only albumin, bilirubin, creatinine, age and the percentage of 13C-PheOx (HR 0.449, 95% CI: 0.206-0.979, P = 0.034) were found to be independent predictors of survival.CONCLUSION: Percentage of 13C-PheOx obtained by 13C-PheBT is a strong predictor of survival in patients with chronic liver disease. | I Gallardo-Wong S Morán G Rodríguez-Leal B Castaeda-Romero R Mera J Poo M Uribe M Dehesa | 2007 | World Journal of Gastroenterology2007，13，34： | 1 |
| 18 | Telomere function in colorectal cancer显示文摘Colorectal cancer is the third most common form of cancer and the second leading cause of cancer-related death in the western world.Tumour cells acquire the hallmarks of cancer during the carcinogenic selection process.Cell immortality is one of the principal features acquired during this process which involves the stabilization of telomere length.It is achieved mainly,by telomerase activation.Thus,the discovery of telomeres and telomerase allowed an understanding of the mechanisms by which cells can become immortalized.Different studies have shown that tumour cells have shorter telomeres than nontumour cells and have detected telomerase activity in the majority of tumours.Survival studies have determined that telomere maintenance and telomerase activity are associated with poor prognosis.Taking into account all the results achieved by different groups,quantification and evaluation of telomerase activity and measurement of telomere length may be useful methods for additional biologic and prognostic staging of colorectal carcinoma. | Cristina Frías Alberto Morán Carmen de Juan Paloma Ortega Tamara Fernández-Marcelo Andrés Sánchez-Pernaute Antonio José Torres Eduardo Díaz-Rubio Manuel Benito Pilar Iniesta | 2009 | World Journal of Gastrointestinal Oncology2009，1，1： | 0 |
| 19 | Adalimumab induction and maintenance therapy for patients with ulcerative colitis previously treated with infliximab显示文摘 | C.Taxonera J.Estellés I.Fernández‐Blanco O.Merino I.Marín‐Jiménez M.Barreiro‐de Acosta C.Saro V.García‐Sánchez E.Gento G.Bastida J. P.Gisbert I.Vera P.Martinez‐Montiel S.Garcia‐Morán M. C.Sánchez J. L.Mendoza | 2011 | Alimentary Pharmacology & Therapeutics2011，，3： | 2 |
| 20 | Transcatheter aortic valve implantation in very elderly patients: immediate results and medium term follow-up显示文摘ObjectiveTo 评估立即的 transcatheter 在有严重、征兆的大动脉的狭窄的很老的病人的大动脉的阀门培植(TAVI ) 结果和中期的后续(作为).MethodsThis multicenter,观察、未来的学习在三所医院里被执行。我们包括了连续很老(>85 年) 病人与作为严重由 TAVI 对待。主要端点是在包括的二 years.ResultsThe 研究从任何原因评估死亡率有一个平均数的 160 个连续病人 87 ± 变老;2.1 年(从 85 ~ 94 年的范围) 和 18.8%± 的吝啬的逻辑 EuroSCORE;11.2% 与 57 (35.6%) 病人得分 ≥20% 。程序的成功率是 97.5% ,与 25 (15.6%) 与主要流血经历尖锐复杂并发症的病人(最经常) 。全球死亡率在住院期间是 8.8%(n = 14 ) 并且 30 天的死亡率是 10%(n = 16 ) 。中部在时期上面列在后面是 252.24 ±232.17 天。在后续时期期间, 28 (17.5%) 病人们死了(他们中的 17 个由于心脏的原因) 。估计的二年全面、心脏的幸存率使用 Kaplan-Meier 方法分别地是 71% 和 86.4% 。比例的危险回归给看了的考克斯可变 EuroSCORE ≥20 是与全面 mortality.ConclusionsTAVI 联系的唯一的变量在很老的病人的一张选择人口安全、有效。我们的调查结果支持在病人的这个复杂的组的这个新过程的采纳。 | Isaac Pascual Antonio J Mu oz-García Diego López-Otero Pablo Avanzas Manuel F Jimenez-Navarro Belén Cid-Alvarez Raquel del Valle Juan H Alonso-Briales Raimundo Ocaranza-Sanchez José M Hemández Ramiro Trillo-Nouche César Morís | 2015 | Journal of Geriatric Cardiology2015，12，4： | 1 |
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