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| 1 | 从附睾到卵子:CRISP蛋白在哺乳动物受精过程中的作用显示文摘哺乳动物的受精过程涉及精卵结合的很多步骤,是一个非常复杂的过程,其分了机制亟待阐明。此篇综述主要论述了CRISP(富含半胱氨酸的分泌蛋白)作为模型分子在哺乳动物受精过程中的价值。大量的体外实验和基因敲出模型研究显示,附睾内的CRISP1以两种不同的亲和力结合于精子表面,参与精子获能、精子-透明带结合、精卵融合的调控。这些研究成果可以延伸至人类。我们住研究中发现,人类具有与啮齿类同源的CRISP(hCRISP1),同样参与受精过样。CRISP家族的其他成员(睾丸内CRISP2、附挈内CRISP3—4、射精时的CRISP3)也参与了精卵结合的过程,提示同源分子间的相互协同有助于受精的成功。另外,我们的研究显示,CRISP蛋白伴随精子穿越男性及女性生殖管道的全过程。我们推测CRISP不仅参与了受精过程,而且可能成为不育和避孕研究的新靶点。 | Vanina G Da Ros Mariana Weigel Munoz Maria A Battistone Nicolas G Brukman Guillermo Carvajal Ludmila Curci Matlas D Gomez-Elias Debora J Cohen Patricia S Cuasnicu | 2015 | Asian Journal of Andrology2015，17，5： | 5 |
| 2 | Central line-associated bloodstream infection among children with biliary atresia listed for liver transplantation显示文摘BACKGROUND Pre-transplant nutrition is a key driver of outcomes following liver transplantation in children.Patients with biliary atresia(BA) may have difficulty achieving satisfactory weight gain with enteral nutrition alone,and parenteral nutrition(PN) may be indicated.While PN has been shown to improve anthropometric parameters of children with BA listed for liver transplantation,less is known about the risks,particularly infectious,associated with this therapy among this specific group of patients.AIM To describe the incidence,microbiology,and risk factors of central line-associated bloodstream infection(CLABSI) among children with BA listed for liver transplantation.METHODS Retrospective review of children aged ≤ 2-years of age with BA who were listed for primary liver transplantation at Texas Children's Hospital from 2008 through2015(n = 96).Patients with a central line for administration of PN(n = 63) were identified and details of each CLABSI event were abstracted.We compared the group of patients who experienced CLABSI to the group who did not,to determine whether demographic,clinical,or laboratory factors correlated with development of CLABSI.RESULTS Nineteen of 63 patients(30%,95%CI:19,43) experienced 29 episodes of CLABSI during 4800 line days(6.04 CLABSI per 1000 line days).CLABSI was predominantly associated with Gram-negative organisms(14/29 episodes,48%)including Klebsiella spp.,Enterobacter spp.,and Escherichia coli.The sole polymicrobial infection grew Enterobacter cloacae and Klebsiella pneumoniae.Grampositive organisms(all Staphylococcus spp.) and fungus(all Candida spp.)comprised 9/29(31%) and 6/29(21%) episodes,respectively.No demographic,clinical,or laboratory factors were significantly associated with an increased risk for the first CLABSI event in Cox proportional hazards regression analysis CONCLUSION There is substantial risk for CLABSI among children with BA listed for liver transplantation.No clinical,demographic,or laboratory factor we tested emerged as an independent predictor of CLABSI.While our data did not show an impact of CLABSI on the short-term clinical outcome,it would seem prudent to implement CLABSI reduction strategies in this population to the extent that each CLABSI event represents potentially preventable hospitalization,unnecessary healthcare dollar expenditures,and may exact an opportunity cost,in terms of missed allograft offers. | Nicole D Triggs Stacey Beer Sonam Mokha Kat Hosek Danielle Guffey Charles G Minard Flor M Munoz Ryan W Himes | 2019 | World Journal of Hepatology2019，11，2： | 2 |
| 3 | Proliferation activety and steroid hormone receptor status in male breast carcinoma显示文摘 | Munoz D E Toro M M Maffini M V | 1998 | J Steroid Biochem Mol Boil1998，67，4： | 1 |
| 4 | Is ex- treme obesity a risk factor for cardiac surgery? An a- nalysis of patients with a BMI:40显示文摘 | Wigfield C H Lindsey J D Munoz A | 2006 | EurJ Cardiotho- rac Surg2006，29，4： | 1 |
| 5 | Visualizing underwater ocean optics 显示文摘 | Gutierrez D Seron F Munoz A | 2008 | Computer Graphics Forum2008，27，2： | 1 |
| 6 | Modeling and design of arrayed waveguide gratings显示文摘 | Munoz P Pastor D Capmany J | 2002 | Lightwave Technol2002，20，4： | 1 |
| 7 | Sensitivity of electricity and natural gas consumption to climate in the USA-Methodology and re- sults for eight states 显示文摘 | Sailor D J Munoz J R | 1997 | Energy1997，22，10： | 1 |
| 8 | Prevalence of dry eye among the elderly显示文摘 | SHEIN O D MUNOZ B TIELSH J M | 1997 | Am J Ophthalmol1997，124，6： | 1 |
| 9 | Sirtl improves healthy ageing and protects from metabolic syndrome-associated cancer显示文摘 | Herranz D Munoz Martin M Canamero M | 2010 | Na- ture Communications2010，1，1： | 1 |
| 10 | Evaluation of a new standardized protocol for the perioperative management of chronically anticoagulated patients receiving implantable cardiac arrhythmia devices显示文摘 | Cano O Munoz B Tejada D | 2012 | Heart Rhythm2012，9，3： | 1 |
| 11 | Preparation and mechanical properties of gluten inrich films 显示文摘 | Hernandez- Munoz P Esprosite P D Sorrentino C | 2004 | Food Hydrocolloids2004，18，： | 1 |
| 12 | Determination of fluorouinolones in urine and serum by using high performance liquid chromatography and ric multiemis sion scan fluorimet- detection 显示文摘 | Espinosa-Mansilia A Munoz de la Pena A Gonzalez Gomez D | 2006 | Talanta2006，68，： | 1 |
| 13 | A new induction motor V/f control method capable of high-performance regulation at low speeds 显示文摘 | GARCIA A Munoz LIPO T A NOVOTNY D W | 1998 | IEEE Transactions on Industry Applications1998，34，4： | 1 |
| 14 | Preparation and mechanical properties of gluten inrich films 显示文摘 | Hernandez- Munoz P Esprosite P D Sorrentino C | 2004 | Food Hydrocolloids2004，18，： | 1 |
| 15 | In utero exposure to bisphenol A alters the development and tissue organization of the mouse mammary gland显示文摘 | Markey C M Luque E H Munoz D T M | 2001 | Biol Reprod2001，65，4： | 1 |
| 16 | Model of risk of cortical cataract in the US population with exposure to increased ultraviolet radiation due to stratospheric ozone depletion 显示文摘 | West S K Longstreth J D Munoz B E | 2005 | Am J Epidemiol2005，162，11： | 1 |
| 17 | A longitudinal study of neutralizing antibodies and disease progression in HIV-1-infected subjects显示文摘 | Cecilia D Kleeberger C Munoz A | 1999 | J Infect Dis1999，179，6： | 1 |
| 18 | Heritability of refractive error and familial aggregation of myopia in an elderly American population 显示文摘 | Wojciechowski R Congdon N Bowie H Munoz B Gilbert D West SK | 2005 | Invest Ophthalmol Vis Sc/2005，46，5： | 1 |
| 19 | A trick shot to the corner pocket显示文摘 | Tran D Q Munoz L Russo G | 2008 | Reg Anesth Pain Med2008，33，5： | 1 |
| 20 | Is 28 extreme obesity a risk factor for cardiac surgery An analysis of patients with a BMI≥40显示文摘 | Joshua D Lindsey Alejandro Munoz | 2006 | Eur J Cardiothoracic Surg2006，29，4： | 1 |
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