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| 1 | Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice显示文摘AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulgaris-treated mdr1a-/- mice. CONCLUSION: The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a-/- mice. | Kelley MK Haarberg Meghan J Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy Jesse M Hostetter Amanda E Ramer-Tait Michael J Wannemuehler | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 8 |
| 2 | The natural history of amyotrophic lateral sclerosis显示文摘 | Ringel SP Murphy JR Alderson MK | 1993 | Neurology1993，43，7： | 1 |
| 3 | TGF ~11, GDF 5, and BMP-2 stimulation induces chondrogenesis in expanded human articular chondrocytes and marrow derived stromal cells 显示文摘 | Murphy MK Huey DJ Hu JC | 2015 | Stem Cells2015，33，3： | 1 |
| 4 | Criteria for polycystic ovarian morphology in polycystic ovary syndrome as a function of age显示文摘 | Alsamarai S Adams JM Murphy MK | 2009 | J Clin Endocrinol Metab2009，94，12： | 1 |
| 5 | Temporomandibular disorders: a review of etiology, clinical management, and tissue cngineering strategies 显示文摘 | Murphy MK MacBarb RF Wong ME | 2013 | lnt J Oral Maxillofac Implants2013，28，6： | 1 |
| 6 | Randomized phase Ⅲ evaluation of cisplatin plus fluorouracil versus cisplatin plus paclitaxel in advanced head and neck cancer (E1395): an intergroup trial of the eastern ooperative oneology group 显示文摘 | Gibson MK Li Y Murphy B | 2005 | Clin Oncol2005，23，15： | 1 |
| 7 | Randomized phase III evaluation of cisplatin plus fluorouracil versus cisplatin plus paclitaxel in advanced head andneck cancer (E1395) :an intergroup trial of the Eastern Cooperative Ontology Group 显示文摘 | Gibson MK Li Y Murphy B | 2005 | J Clin Oncol2005，23，15： | 1 |
| 8 | Randomized phase Ⅲ evaluation of cisplatin plus fluorouracil versus cisplatin plus paclitaxel in advanced head and neck cancer (E1395):an intergroup trial of the Eastern Cooperative Oncology Group显示文摘 | Gibson MK Li Y Murphy B | 2005 | J Clin Oncol2005，23，15： | 1 |
| 9 | E- valuation of the new cesium-131 seed for use in low-energy X-ray brachytherapy 显示文摘 | Murphy MK Piper PK Greenwood LR | 2004 | Medical Physics2004，31，6： | 1 |
| 10 | Filaggrin deficient mice exhibitThl7 - dominated skin inflammation and permissiveness to epicutaneoussensitization with protein antigen显示文摘 | Oyoshi MK Murphy GF Geha RS | 2009 | J Allergy Clin Immunol2009，124，3： | 1 |
| 11 | Evaluation of the new cesium- 131 seed for use in low-energy X-ray brachytherapy 显示文摘 | Murphy MK Piper RK Greenwood LR | 2004 | Medical Physics2004，31，4： | 1 |
| 12 | Craving as an alcohol use disorder symptom in DSM - 5 : an empirical examination in a treatment -seeking sample显示文摘 | Murphy CM Stojek MK Few LR | 2014 | Exp Clin Psychopharm2014，22，： | 1 |
| 13 | Consensus development methods and their use in clinical guideline development显示文摘 | Black N Lamping DL | 1998 | Health Technology Assessment1998，2，3： | 1 |
| 14 | Randomized phase III evaluation of cisplatin plus fluorouracil versus cisplatin plus paclitaxel in advanced head and neck cancer (E1395): an intergroup trial of the Eastern Cooperative Oncology Group 显示文摘 | Gibson MK Li Y Murphy B | 2005 | J Clin Oncol2005，23，15： | 1 |
| 15 | Embolization of bronchial arteries with N- butyl cyanoacrylate for management of massive hemoptysis: a technical review显示文摘 | Razavi MK Murphy K | 2007 | Tech Vasc Interv Radiol2007，10，： | 1 |
| 16 | Randomized phase Ⅲ evaluation of cisplatin plus fluorouracil versus cisplatin plus paclitaxel in advanced head and neck cancer (E1395):an Intergroup trial of the Eastern Cooperative Oncology Group显示文摘 | Li Y Murphy B | 2005 | J Clin Oncol2005，23，： | 1 |
| 17 | The natural history of amyotrophic lateral sclerosis 显示文摘 | Ringel SP Murphy JR Alderson MK | 1993 | Neurology1993，43，7： | 1 |
| 18 | Criteria for polycystic ovarian morphology in polycystic ovary syndrome as a function of age 显示文摘 | Alsamarai S Adams JM Murphy MK | 2009 | J Clin Endocrinol Metab2009，94，12： | 1 |
| 19 | Evalua- tion of the new cesium-131 seed for use in low-energy X-ray brachytherapy显示文摘 | Murphy MK Piper RK Greenwood LR | 2004 | Medical Physics2004，31，4： | 1 |
| 20 | Unconjugated hilirubin in human bile:the nucleating factor in cholesterol cholelithiasis? 显示文摘 | Dutt MK Murphy GM Thompson RP | 2003 | J Clin Pathol2003，56，8： | 1 |
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