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| 1 | Evidence for a sequential transfer of iron amongst ferritin, transferrin and transferrin receptor during duodenal absorption of iron in rat and human显示文摘AIM: To elucidate the sequential transfer of iron amongst ferritin, transferrin and transferrin receptor under various iron status conditions. METHODS: Incorporation of 59Fe into mucosal and luminal proteins was carried out in control WKY rats. The sequential transfer of iron amongst ferritin, transferrin and transferrin receptor was carried out in iron deficient, control and iron overloaded rats. The duodenal proteins were subjected to immunoprecipitation and quantitation by specific ELISA and in situ localization by microautoradiography and immunohistochemistry in tandem duodenal sections. Human duodenal biopsy (n = 36) collected from subjects with differing iron status were also stained for these proteins. RESULTS: Ferritin was identified as the major protein that incorporated iron in a time-dependent manner in the duodenal mucosa. The concentration of mucosal ferritin was significantly higher in the iron excess group compared to control, iron deficient groups (731.5 ± 191.96 vs 308.3 ± 123.36, 731.5 ± 191.96 vs 256.0 ± 1.19, P < 0.005), while that of luminal transferrin which was significantly higher than the mucosal did not differ among the groups (10.9 ± 7.6 vs 0.87 ± 0.79, 11.1 ± 10.3 vs 0.80 ± 1.20, 6.8 ± 4.7 vs 0.61 ± 0.63, P < 0.001). In situ grading of proteins and iron, and their superimposition, suggested the occurrence of a sequential transfer of iron. This was demonstrated to occur through the initial binding of iron to luminal transferrin then to absorptive cell surface transferrin receptors. The staining intensity of these proteins variedaccording to the iron nutrition in humans, with intense staining of transferrin receptor observed in iron deficient subjects. CONCLUSION: It is concluded that the intestine takes up iron through a sequential transfer involving interaction of luminal transferrin, transferrin-transferrin receptor and ferritin. | Vasantha L Kolachala B Sesikeran K Madhavan Nair | 2007 | World Journal of Gastroenterology2007，13，7： | 2 |
| 2 | Estrogen stimulates microglia and brain recovery from hypoxia-ischemia in normoglycemic but not diabetic female mice 显示文摘 | Zhang L Nair A Krady K | 2004 | J Clin Invest2004，113，1： | 1 |
| 3 | Injectable hydrogels for bone and cartilage repair 显示文摘 | A:nini A A Nair L S | 2012 | Biomed Mater2012，7，02： | 1 |
| 4 | Global association of air pollution and heart failure: a systematic review and meta-analysis显示文摘 | Anoop SV Shah Jeremy P Langrish Harish Nair David A McAllister Amanda L Hunter Ken Donaldson David E Newby Nicholas L Mills | 2013 | The Lancet2013，，： | 1 |
| 5 | The epileptogenic zone:general principles显示文摘 | Lüders HO Najm I Nair D | | 0，，2： | 1 |
| 6 | Fuzzy Models for Single-period Inventory Problem 显示文摘 | Li L Kabadi S N Nair K P K | 2002 | Fuzzy sets and systems2002，，132： | 1 |
| 7 | Serum proealcitonin and infective exacerbations of asthma显示文摘 | Dsilva L Hassan N Nair P | 2011 | Chest2011，140，5： | 1 |
| 8 | Rival penalized competitive learning (RPCL): a topoogy- determining agorithm for analyzing gene expression data 显示文摘 | NAIR T M ZHENG C L FINK J L | 2003 | Computational Bioogy and Chemistry2003，27，6： | 1 |
| 9 | Optimum pumppulse duration for optical parametric oscillators显示文摘 | R C Bapna K Dasqupta L G Nair | 1997 | Optics & Laser Technology1997，26，6： | 1 |
| 10 | Rival penalized competitive learning (RPCL) : a topology-determining algorithm for analyzing gene expression data 显示文摘 | NAIR T M ZHENG C L FINK J L STUART R O GRIBSKOV M | 2003 | Computational Biology and Chemistry2003，27，6： | 1 |
| 11 | The Impact of FDI and Financial Sector Development on Economic Growth: Empirical Evidence from Asia and Oceania 显示文摘 | Chee L Y Nair M | 2010 | International Journal of Economics and Finance2010，，2： | 1 |
| 12 | Selective lethal photosensitization of methicillin-resistant Staph- ylococcus aureus using an IgG-tin (IV) chlorin e6 conjugate显示文摘 | EMBLETON M L NAIR S P COOKSON B D | 2002 | Journal of Antimicrobial Chemotherapy2002，50，6： | 1 |
| 13 | Determination of polysorbate 80 in parenteral formulations by highperformance liquid chromatography and evaporative light scattering detection显示文摘 | NAIR L M STEPHENS N V VINCENT S V | 2003 | J Chromatogr A2003，1012，1： | 1 |
| 14 | Safety and efficacy of ibutilide in cardioversion of atrial flutter and fibrillation 显示文摘 | Nair M George L K Koshy S K | 2011 | J Am Board Fam Med2011，24，1： | 1 |
| 15 | Antibody-directed photodynamic therapy of methicillin resistant Staphylococcus aureus显示文摘 | EMBLETON M L NAIR S P COOKSON B D | 2004 | Microbial Drug Resistance2004，10，2： | 1 |
| 16 | Changes in expression,and/or mutations in TGF-beta receptors (TGF-beta RI and TGF-beta RII) and Smad 4 in human ovarian tumors显示文摘 | ANTONY M L NAIR R SEBASTIAN P | 2010 | J Cancer Res Clin Oncol2010，136，3： | 1 |
| 17 | Graphene-based liquid crystal device 显示文摘 | BLAKE P BRIMICOMBE P D NAIR R R BOOTH T J JIANG D SCHEDIN F PONOMARENKO L A MOROZOV S V GLEESON H F HILL E W GEIM A K NOVOSELOV K S | 2008 | Nano Letters2008，8，6： | 1 |
| 18 | Association of obesity and insulinresistance with dyslipidemia in Indian women withpolycystic ovarian syndrome显示文摘 | Kalra A Nair S Rai L | 2006 | Indian J Med Sci2006，60，11： | 1 |
| 19 | 查看详情显示文摘 | S G Kumbar S P Nukavarapu R James L S Nair C T Laurencin | | 0，，： | 1 |
| 20 | 查看详情显示文摘 | Gabor N M Song J Ma Q Nair N L Taychatanapat T Watanabe K Taniguchi T Levitov L S Jarillo-Herrero P | | 0，，： | 1 |
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