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| 1 | Non-alcoholic fatty liver disease and diabetes: From physiopathological interplay to diagnosis and treatment显示文摘Non-alcoholic fatty liver disease(NAFLD)is highly prevalent in patients with diabetes mellitus and increasing evidence suggests that patients with type 2diabetes are at a particularly high risk for developing the progressive forms of NAFLD,non-alcoholic steatohepatitis and associated advanced liver fibrosis.Moreover,diabetes is an independent risk factor for NAFLD progression,and for hepatocellular carcinoma development and liver-related mortality in prospective studies.Notwithstanding,patients with NAFLD have an elevated prevalence of prediabetes.Recent studies have shown that NAFLD presence predicts the development of type2 diabetes.Diabetes and NAFLD have mutual pathogenetic mechanisms and it is possible that genetic and environmental factors interact with metabolic derangements to accelerate NAFLD progression in diabetic patients.The diagnosis of the more advanced stages of NAFLD in diabetic patients shares the same challenges as in non-diabetic patients and it includes imaging and serological methods,although histopathological evaluation is still considered the gold standard diagnostic method.An effective established treatment is not yet available for patients with steatohepatitis and fibrosis and randomized clinical trials including only diabetic patients are lacking.We sought to outline the published data including epidemiology,pathogenesis,diagnosis and treatment of NAFLD in diabetic patients,in order to better understand the interplay between these two prevalent diseases and identify the gaps that still need to be fulfilled in the management of NAFLD in patients with diabetes mellitus. | Nathalie C Leite Cristiane A Villela-Nogueira Claudia R L Cardoso Gil F Salles | 2014 | World Journal of Gastroenterology2014，20，26： | 21 |
| 2 | LncRNA-encoded peptides: More than translational noise?显示文摘 | Nathalie Rion Markus A R #x000FC egg | 2017 | Cell Research2017，27，5： | 8 |
| 3 | High-fidelity multimode fibre-based endoscopy for deep brain in vivo imaging显示文摘Progress in neuroscience relies on new techniques for investigating the complex dynamics of neuronal networks.An ongoing challenge is to achieve minimally invasive and high-resolution observations of neuronal activity in vivo inside deep brain areas.Recently introduced methods for holographic control of light propagation in complex media enable the use of a hair-thin multimode optical fibre as an ultranarrow imaging tool.Compared to endoscopes based on graded-index lenses or fibre bundles,this new approach offers a footprint reduction exceeding an order of magnitude,combined with a significant enhancement in resolution.We designed a compact and high-speed system for fluorescent imaging at the tip of a fibre,achieving a resolution of 1.18±0.04μm across a 50-μm field of view,yielding 7-kilopixel images at a rate of 3.5 frames/s.Furthermore,we demonstrate in vivo observations of cell bodies and processes of inhibitory neurons within deep layers of the visual cortex and hippocampus of anaesthetised mice.This study paves the way for modern microscopy to be applied deep inside tissues of living animal models while exerting a minimal impact on their structural and functional properties. | Sergey Turtaev Ivo T.Leite Tristan Altwegg-Boussac Janelle M.P.Pakan Nathalie L.Rochefort Tomáš Čižmár | 2018 | Light(Science & Applications)2018，7，1： | 8 |
| 4 | Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates显示文摘Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)pandemic.Plant-derived virus-like particle(VLP)vaccine candidates have previously demonstrated immunogenicity and efficacy against influenza.Here,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein(CoVLP)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)1018.Although a single dose of the unadjuvanted CoVLP vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted CoVLP.Fifteen micrograms of CoVLP adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T cells.Animals were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of SARS-CoV-2.Lower viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLP adjuvanted with AS03.No clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated animals.The CoVLP adjuvanted with AS03 was therefore selected for vaccine development and clinical trials. | Stéphane Pillet Prabhu SArunachalam Guadalupe Andreani Nadia Golden Jane Fontenot Pyone Pyone Aye Katharina Röltgen Gabrielle Lehmicke Philipe Gobeil Charlotte Dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue Christopher Monjure Robert V.Blair Scott D.Boyd Rudolf P.Bohm Jay Rappaport François Villinger Nathalie Landry Bali Pulendran Brian J.Ward | 2022 | Cellular & Molecular Immunology2022，19，2： | 2 |
| 5 | Support vector machine for functional data classi? cation 显示文摘 | FABRICE R NATHALIE V | 2006 | Neurocomputing2006，69，： | 1 |
| 6 | Parthenogenesis in mammals 显示文摘 | Nathalie R | 2001 | Mol Reprod Dev2001，59，： | 1 |
| 7 | Fiber optic pH sensor for early detection of danger of corrosion in steel-reinforced concrete structures显示文摘 | Nathalie Dantan Wolfgang R Habel Otto S Wolfbeis | 2005 | SPIE2005，5758，： | 1 |
| 8 | Current advances in abscisic acid action and signalling显示文摘 | Jér?me Giraudat Fran?ois Parcy Nathalie Bertauche Fran?oise Gosti Jeffrey Leung Peter-Christian Morris Michelle Bouvier-Durand Nicole Vartanian | 1994 | Plant Molecular Biology1994，，5： | 1 |
| 9 | StGCPRP,a potato gene strongly expressed in stomatal guard cells,defines a novel type of repetitive proline-rich proteins显示文摘 | Menke U Nathalie R Bernd M R | 2000 | Plant physiology2000，122，3： | 1 |
| 10 | Lung lesions in pigs at slaughter: A 2-year epidemiological studying in France 显示文摘 | Philippe L Nathalie R Alassane K | 2005 | Appl Res Vet M2005，3，： | 1 |
| 11 | Varicella-zoster virus does not signicantly induce the cell defence mechanism mediated by the 2- 5A/RNase L pathway during显示文摘 | Nathalie D Markus R Manfred H | 2005 | Med Microbiol Immunol2005，194，6： | 1 |
| 12 | Does sciatic parasacral injection spread to the obturator nerve an an- atomic study显示文摘 | Nathalie V Jacques R Emmanuel N | 2008 | Anesth Analg2008，106，： | 1 |
| 13 | Decomposition and nutrient release from radiata pine ( Pinus radiata ) coarse woody debris显示文摘 | Girisha K Ganjegunte Leo M Condron Peter W Clinton Murray R Davis Nathalie Mahieu | 2003 | Forest Ecology and Management2003，，2： | 1 |
| 14 | From sleep spindles of natural sleep to spike and wave discharges of typical absence seizures: is the hypothesis still valid?显示文摘 | Nathalie Leresche Régis Lambert Adam Errington Vincenzo Crunelli | 2012 | Pflügers Archiv - European Journal of Physiology2012，，1： | 1 |
| 15 | Caseinomacropeptides specifically stimulates exocrine pancreatic secretion in the anesthetized rat显示文摘 | Nathalie L R Claire N D Sylvain M | 2000 | Science Direct-Peptides2000，21，10： | 1 |
| 16 | Expression of lipoxygenase isoenzymes in developing barley grains显示文摘 | Nathalie F Schmitt Jan R Van Mechelen | 1997 | Plant Science1997，，128： | 1 |
| 17 | Pulmonary apoptosis after supraceliac aorta clamping in a rat model显示文摘 | Collange 0 Fabienne T Nathalie R | 2005 | J Surg Res2005，129，2： | 1 |
| 18 | Supply chain integration:the role of logistics service providers显示文摘 | NATHALIE F MARIANNE J CHRISTINE R | 2009 | International Journal of Productivity and Performance Management2009，58，1： | 1 |
| 19 | Wewer and pascale guicheney selenoprotein N: an endoplasmic reticulum glycoprotein with an early developmental expression pattern 显示文摘 | NATHALIE P ALAIN L MATHIEU R | 2003 | Hum Mol Gen- et2003，12，9： | 1 |
| 20 | Regulation of acp1, encoding a non-aspartyl acid protease expressed during pathogenesis of Sclerotinia sclerotiorum显示文摘 | SANDRINE C GENEVIEVE B CHRISTINE R MICHEL F | 2001 | Microbiology2001，147，： | 1 |
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