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| 1 | More anxious than depressed:prevalence and correlates in a 15-nation study of anxiety disorders in people with type 2 diabetes mellitus显示文摘Background Anxiety disorder, one of the highly disabling, prevalent and common mental disorders, is known to be more prevalent in persons with type 2 diabetes mellitus (T2DM) than the general population, and the comorbid presence of anxiety disorders is known to have an impact on the diabetes outcome and the quality of life. However, the information on the type of anxiety disorder and its prevalence in persons with T2DM is limited. Aims To assess the prevalence and correlates of anxiety disorder in people with type 2 diabetes in different countries. Methods People aged 18-65 years with diabetes and treated in outpatient settings were recruited in 15 countries and underwent a psychiatric interview with the Mini-International Neuropsychiatric Interview. Demographic and medical record data were collected. Results A total of 3170 people with type 2 diabetes (56.2% women;with mean (SD) duration of diabetes 10.01 (7.0) years) participated. The overall prevalence of anxiety disorders in type 2 diabetic persons was 18%;however, 2.8% of the study population had more than one type of anxiety disorder. The most prevalent anxiety disorders were generalised anxiety disorder (8.1%) and panic disorder (5.1%). Female gender, presence of diabetic complications, longer duration of diabetes and poorer glycaemic control (HbA1c levels) were significantly associated with comorbid anxiety disorder. A higher prevalence of anxiety disorders was observed in Ukraine, Saudi Arabia and Argentina with a lower prevalence in Bangladesh and India. Conclusions Our international study shows that people with type 2 diabetes have a high prevalence of anxiety disorders, especially women, those with diabetic complications, those with a longer duration of diabetes and poorer glycaemic control. Early identification and appropriate timely care of psychiatric problems of people with type 2 diabetes is warranted. | Santosh K Chaturvedi Shayanth Manche Gowda Helal Uddin Ahmed Fahad D Alosaimi Nicola Andreone Alexey Bobrov Viola Bulgari Giuseppe Carra Gianluca Castelnuovo Giovanni de Girolamo Tomasz Gondek Nikola Jovanovic Thummala Kamala Andrzej Ki Nebojsa Lalic Dusica Lecic-Tosevski Fareed Minhas Victoria Mutiso David Ndetei Golam Rabbani Suntibenchakul Somruk Sathyanarayana Srikanta Rizwan Taj Umberto Valentini Olivera Vukovic Wolfgang Wolwer Larry Cimino Arie Nouwen Cathy Lloyd Norman Sartorius | 2019 | General Psychiatry2019，32，4： | 11 |
| 2 | EBV阴性侵袭性NK细胞白血病/淋巴瘤的临床、病理及分子遗传学特征显示文摘侵袭性NK细胞淋巴瘤(ANKL)是一种系统性NK细胞肿瘤,与EB病毒(EBV)有关。EBV阴性的ANKL临床罕见,且提示具有惰性的生物学行为。作者报道7例EBV阴性ANKL的临床病理、免疫表型及分子遗传学特征。 | Nicolae A Ganapathi K A Pham T H 魏建国 许春伟 | 2017 | 临床与实验病理学杂志2017，33，5： | 10 |
| 3 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 4 | Spontaneous bacterial peritonitis prevalence in pretransplant patients and its effect on survival and graft loss post-transplant显示文摘AIM To investigate the incidence of spontaneous bacterial peritonitis(SBP) in pre-transplant patients and its effect on post transplant mortality and graft failure. METHODS We conducted a retrospective cohort study of patient records from the organ procurement and transplant network data set. Patients were identified by the presence of SBP pre-transplant. Univariate post-transplant survival models were constructed using the Kaplan-Meier technique and multivariate models were constructed using the Cox proportional hazards model. Variables that affected post-transplant graft survival were identified in the SBP population. RESULTS Forty-seven thousand eight hundred and eighty patient records were included in the analysis for both groups, and 1966(4.11%) patients were identified in the data set as having pre-transplant SBP. Patients that had pre-transplant SBP had higher rates of graft loss from recurrent hepatitis C virus(HCV)(3.6% vs 2.0%, P < 0.0001), infections leading to graft loss(1.9% vs 1.3%, P = 0.02), primary non-function(4.3% vs 3.0%, P < 0.0001) and chronic rejection(1.1% vs 0.7%, P = 0.04). Kaplan-Meier survival analysis showed a statistically significant difference in all-cause survival in patients with a history of SBP vs those without(P < 0.0001). Pretransplant history of SBP was independently predictiveof mortality due to recurrent HCV(HR = 1.11, 95%CI: 1.02-1.21, P < 0.017) after liver transplantation.CONCLUSION HCV patients prior to the advent of directing acting anti-viral agents had a higher incidence of pre-transplant SBP than other patients on the liver transplant wait list. SBP history pre-transplant resulted in a higher rate of graft loss due to recurrent HCV infection and chronic rejection. | Neeral L Shah Nicolas M Intagliata Zachary H Henry Curtis K Argo Patrick G Northup | 2016 | World Journal of Hepatology2016，8，36： | 2 |
| 5 | Chemistry and biology of diazonamide A: First total synthesis and confirmation of the true structure显示文摘 | Nicolaou K C Chen D Y K Huang X | 2004 | J Am Chem Soc2004，126，12： | 1 |
| 6 | Epithelial to mesenehymal transition in Madin-Darby canine kidney cells is accompanied by down-regulation of Smad3 expression, leading to resistance to transforming growth factor-beta- induced growth arrest显示文摘 | Nicolas FJ Lehmann K Wame PH | 2003 | J Biol Chem2003，278，5： | 1 |
| 7 | Remote sensing of spring phenology in boreal regions:A free of snow-effect method using NOAA-AVHRR and SPOT-VGT data显示文摘 | NICOLAS D THUY L T LAURENT K | | 0，，01： | 1 |
| 8 | Molecular and func- tional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells显示文摘 | De Bosscher K Hill C S Nicola's F J | 2004 | Biochem2004，379，： | 1 |
| 9 | The second total synthesis of diazonamide A显示文摘 | Nicolaou K C Rao P B Hao J | 2003 | Angew Chem Int Ed2003，42，： | 1 |
| 10 | A continuous spectrophotometric linked enzyme assay for transglutaminase activity 显示文摘 | Nicolas D Jeffrey W K | 1999 | Analy Bioche1999，274，： | 1 |
| 11 | 'The Art and Science of Total Synthesis at the Down of the Twenty-Frist Centry' Angen显示文摘 | Vourloumis D Winssinger N | 2000 | Chem Int Ed Engl2000，39，： | 1 |
| 12 | Palladium-catalyzed cross-coupling reactions in total synthesis 显示文摘 | Nicolaou K C Bulger P G Sarlah D | 2005 | Angew Chem : lnt Ed Engl2005，44，29： | 1 |
| 13 | Chemistry and biology of diazonamide A: Second total synthesis and biological investigations显示文摘 | Nicolaou K C Hao J Reddy M V | 2004 | J Am Chem Soc2004，126，12： | 1 |
| 14 | Perspective in total synthesis:a personal account显示文摘 | Nicolaou K C | 2003 | Tetrahedron2003，59，35： | 1 |
| 15 | Low-band gap polymers for photovoltaic applications 显示文摘 | Colladet K Nicolas M Goris L | 2004 | Thin Solid Films2004，45，： | 1 |
| 16 | Discovery of a biologi- cally active thiostrepton fragment 显示文摘 | Nicolaou K C Zak M Rahimipour S | 2005 | J Am Chem Soc2005，127，15： | 1 |
| 17 | Chemical synthesis and biolog- ical evaluation of novel epothilone B and trans-12,13-cyclopropyl epothilone B analogues显示文摘 | Nicolaou KC Ritz n A Namoto K | 2002 | Tetrahedron2002，58，32： | 1 |
| 18 | Palladium-catalyzed Cross-coupling Reactions in Total Synthesis 显示文摘 | Nicolaou K C Bulger P G Sarlah D | 2005 | Angew Chem Int Ed2005，44，29： | 1 |
| 19 | Matching of Palmprlnts显示文摘 | Nicolae Duta Anil K J a in Kanti V Mardia | 2002 | Pattern Recognition Letters2002，23，： | 1 |
| 20 | Layer-by-layer films as a biomimetic reservoir for rhBMP--2 delivery: Controlled differentiation of myoblasts to osteoblasts显示文摘 | Crouzier T Ren K F Nicolas C | 2009 | Small2009，5，5： | 1 |
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