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| 1 | Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers显示文摘Background: Vitamin A and its metabolite,retinoic acid(RA),are important regulators of cell differentiation and organ morphogenesis.Its impact on beef cattle muscle growth remains undefined.Method: Angus steer calves were administrated with 0(control) or 150,000 IU vitamin A(retinyl palmitate in glycerol,i.m.) per calf at birth and 1 month of age.At 2 months of age,a biopsy of the Biceps femoris muscle was obtained to analyze the immediate effects of vitamin A injection on myogenic capacity of muscle cells.The resulting steers were harvested at 14 months of age.Results: Vitamin A administration increased cattle growth at 2 months.At 2 months of age,Vitamin A increased PAX7 positive satellite cells and the expression of myogenic marker genes including PAX7,MYF5,MYOD and MYOG.Muscle derived mononuclear cells were further isolated and induced myogenesis in vitro.More myotubes and a higher degree of myogenesis was observed in vitamin A groups.Consistently,vitamin A increased Latissimus dorsi(LD) muscle fiber size at harvest.In addition,vitamin A increased the ratio of oxidative type I and type IIA fibers and reduced the glycolic type IIX fibers.Furthermore,we found that RA,a key bioactive metabolite of vitamin A,activated PPARGC1 A promoter,which explains the upregulated expression of PPARGC1 A in skeletal muscle.Conclusion: Vitamin A administration to neonatal calves enhanced postnatal muscle growth by promoting myogenesis and increasing satellite cell density,accompanied with a shift to oxidative muscle fibers. | Bo Wang Wei Nie Xing Fu Jeanene M de Avila Yannan Ma Mei-Jun Zhu Martin Maquivar Steven M Parish Jan R Busboom Mark L Nelson Min Du | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 3 |
| 2 | Cloning,Expression and Mutation allalysis of NORI,a novel human gene down regulated in HNE1 nasopharyngeal carcinoma cell line显示文摘 | NIE X M ZHANG B C LI G Y | 2003 | J Cancer Res Clin Oncol2003，129，7： | 1 |
| 3 | Transcriptional regulation of cyclooxygenase 2 by bradykinin and interleukin-lbeta in human airway smooth muscle cells:involvement of different promoter elements, transcription factors, and hi stone h4 acetylation 显示文摘 | Nie M Pang L Inoue H | 2003 | Mol Cell Biol2003，23，24： | 1 |
| 4 | Comparison of the Population Capacity of Hematopoietic and Mesenchymal Stem Cells in Experimental Colitis Rat Model显示文摘 | Wei Y M Nie Y Q Lai J Y | 2009 | Transplantation2009，88，1： | 1 |
| 5 | Quantum dot bioconjugates for ultrasensitive nonisotopic detection显示文摘 | Chan W C W Nie S M | 1998 | Science1998，281，： | 1 |
| 6 | Rho signaling and tight junction functions显示文摘 | Terry S Nie M Matter K | 2010 | Physiology (Bethesda)2010，25，： | 1 |
| 7 | Regression reformulations of LLE and LTSA with locally linear transformation显示文摘 | Xiang S M Nie F P Pan C H | | 0，，： | 1 |
| 8 | Material research for planar SOFC stack显示文摘 | T.-L Wen D Wang M Chen H Tu Z Lu Z Zhang H Nie W Huang | 2002 | Solid State Ionics2002，，3： | 1 |
| 9 | Periodic segregation of solute atoms in fully coherent twin boundaries 显示文摘 | NIE J ZHU Y M LIU J Z FANG X Y | 2013 | Science2013，340，： | 1 |
| 10 | Pyridylhydrazone-based PE- Gylation for pH-rcversible lipopolyplex shielding 显示文摘 | NIE Y GUNTHER M GU Z | 2011 | Biomateri- als2011，32，3： | 1 |
| 11 | Calorimetric investigation of the aluminum-water reaction显示文摘 | NIE H SCHOENITZ M DREIZIN E L | 2012 | International Journal of Hydrogen Energy2012，37，11： | 1 |
| 12 | Discrimination of different ganoderma species and their region based on GC-MS profiles of sterols and pattern recognition techniques显示文摘 | Shen M Y Xie M Y Nie S P | 2011 | Anal Lett2011，44，5： | 1 |
| 13 | A study of MDL improvement for the in vivo measurement of lead in bone 显示文摘 | Nie H Fiona M Joanne O | 2004 | Nucl Instru & Metho in Phys Resear B2004，213，： | 1 |
| 14 | A Dempster-Shafer model for query expansion显示文摘 | Wang M W Nie J Y | 2004 | Journal of Jiangxi Normal University (Nature Science)2004，29，3： | 1 |
| 15 | Expression of open reading frames in silkworm pupal cDNA library 显示文摘 | Zhang Y Z Chen J Nie Z M | 2007 | Appl Biochem Bio- technol2007，136，3： | 1 |
| 16 | Complete sequence and organization of Antheraea pernyi nucleopolyhedrovirus, a dr-rich baculovirus 显示文摘 | Nie Z M Zhang Z F Wang D | 2007 | BMC Genomics2007，8，： | 1 |
| 17 | Emulsification in a microfluidic flow-focusing device: Effect of the viscosities of the liquids显示文摘 | Nie Z Seo M S Xu S | 2008 | MicrofluidNanofluid2008，5，5： | 1 |
| 18 | Tuning the optical and electronic properties of colloidal nanoparticles by lattice strain 显示文摘 | SMITH A M MOHS A M NIE S | 2008 | Nature Nanotechnology2008，4，1： | 1 |
| 19 | Determination of speciation of elements related to blood sugar in bioactive extracts from Cyclocarya paliurus leaves by FIA-ICP-MS 显示文摘 | Xie M Y Li L Nie S P | 2006 | Eur Food ResTechnol2006，223，2： | 1 |
| 20 | Identifying global exceptional patterns in multi-database mining显示文摘 | Zhang C Q Liu M L Nie W L | | 0，，01： | 1 |
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