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| 1 | Therapeutic proteasome inhibition in experimental acute pancreatitis显示文摘AIM: To establish the therapeutic potential of proteasome inhibition, we examined the therapeutic effects of MG132 (Z-Leu-Leu-Leu-aldehyde) in an experimental model of acute pancreatitis.METHODS: Pancreatitis was induced in rats by two hourly intraperitoneal (ip) injections of cholecystokinin octapeptide (CCK; 2 x 100 μg/kg) and the proteasome inhibitor MG132 (10 mg/kg ip) was administered 30 min after the second CCK injection. Animals were sacrificed 4 h after the first injection of CCK.RESULTS: Administering the proteasome inhibitor MG132 (at a dose of 10 mg/kg, ip) 90 min after the onset of pancreatic inflammation induced the expression of cell-protective 72 kDa heat shock protein (HSP72) and decreased DNA-binding of nuclear factor-kB (NF-kB). Furthermore MG132 treatment resulted in milder inflammatory response and cellular damage, as revealed by improved laboratory and histological parameters of pancreatitis and associated oxidative stress.CONCLUSION: Our findings suggest that proteasome inhibition might be beneficial not only for the prevention, but also for the therapy of acute pancreatitis. | Tamás Letoha Liliána Z Fehér László Pecze Csaba Somlai Ilona Varga József Kaszaki Gábor Tóth Csaba Vizler László Tiszlavicz Tamás Takács | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 2 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 3 | A dynamic system model for lubricated sliding wear and running显示文摘 | HU Y Z LI Na KRISTIAN T | 1991 | Journal of Tribology1991，113，： | 2 |
| 4 | N20 and NO emissions from co-firing MSW with coals in pilot scale CFBC显示文摘 | Li Z W Lu Q G Na Y J | 2004 | Fuel Processing Technology2004，85，14： | 1 |
| 5 | In vitro and in vivo comparison of two suprachoroidal shunts 显示文摘 | Oatts JT Zhang Z Tseng H Shields MB Sinard JH Loewen NA | 2013 | Invest Ophthalrrwl Vis Sci2013，54，8： | 1 |
| 6 | Efficacy and Safety of Dutasteride in Chinese Adults with Symptomatic Benign Prostatic Hyperplasia显示文摘 | Na Y Ye Z Zhang S | 2012 | Clinical drug investigation2012，32，1： | 1 |
| 7 | Intrapleural heparin or heparin combined with human recombinant DNase is not effective in the treatment of emphysema in a rabbit model显示文摘 | Dikensoy O Zhu Z Na MJ etc | 2006 | Respirology2006，11，： | 1 |
| 8 | Global chemome study by LC coupled with DAD and ESI-Q-TOF MS of a comosite traditional Chinese medicine Qishenyiqi Dropping Pills 显示文摘 | WANG J NA W ZHAO H Z | 2010 | Chromatographia2010，72，3： | 1 |
| 9 | The insulin-like growth factor binding protein superfamily显示文摘 | Poretsky L Cataldo NA Rosenwaks Z | 1999 | Endocrine Rev1999，20，4： | 1 |
| 10 | Propofol neuroprotection in cerebral ischemia and its effects on low-molecular-weight antioxidants and skilled motor tasks显示文摘 | Bayona NA Gelb AW Jiang Z | 2004 | Anesthesiology2004，100，： | 1 |
| 11 | Exaggerated left ventricular dilation and reduced collagen deposition after myocardial infarction in mice lacking osteopontin显示文摘 | Trueblood NA Xie Z Communal C | 2001 | Circ Res2001，88，10： | 1 |
| 12 | Suppression of metastatic hemangiosarcoma by a parvovirus MVMp vector transducing the IP-10 chemokine into immunocompetent alice显示文摘 | Giese NA Raykov Z DeMartino L | 2002 | Cancer Gene Ther2002，9，5： | 1 |
| 13 | Mechanism and kinetics of cyanogens chloride formation from the chlorination of glycine 显示文摘 | Na C Z Olson T M | 2006 | Environment Science and Technology2006，40，5： | 1 |
| 14 | The insu- lin-related ovarian regulatory system in health and disease 显示文摘 | Poretsky L Cataldo NA Rosenwaks Z | 1999 | Endocr1999，20，4： | 1 |
| 15 | Acytological study of Camellia reticulata and its related species in Yunnan, China显示文摘 | KONDO K GU Z J NA H Y | 1986 | La Kromosomo1986，2，4344： | 1 |
| 16 | Exaggerated left ventricular dilation and reduced collagen deposition after myocardial infarction in mice lacking osteopontin显示文摘 | Trueblood NA Xie Z Communal C | 2001 | Circ Res2001，88，10： | 1 |
| 17 | Exaggerated left ven- tricular dilation and reduced collagen deposition after myocardial infarction in mice lacking osteopontin显示文摘 | Trueblood NA Xie Z Communal C | 2001 | Circ Res2001，88，10： | 1 |
| 18 | Gelsemium alkaloids, immunosuppressive agents from Gelsemium elegans 显示文摘 | XU Y K LIAO S G NA Z | 2012 | Fitoterapia2012，83，6： | 1 |
| 19 | Pathogenesis study of enterovirus 71 infection in rhesus monkeys 显示文摘 | Zhang Y Cui W Liu L Wang J Zhao H Liao Y Na R Dong C Wang L Xie Z Gao J Cui P Zhang X Li Q | 2011 | Lab Invest2011，91，9： | 1 |
| 20 | Measurement of adhesion work of electrospun poly- mer membrane by shaft-loaded blister test显示文摘 | Na H Chen P Wan K T Wong S C Li Q Ma Z | 2012 | Lang- muir2012，28，16： | 1 |
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