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| 1 | Alcoholic liver disease:Utility of animal models显示文摘Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Experimental animal models of ALD, particularly rodents, have been used extensively to mimic human ALD. An ideal animal model should recapitulate all aspects of the ALD process, including significant steatosis, hepatic neutrophil infiltration, and liver injury. A better strategy against ALD depends on clear diagnostic biomarkers, accurate predictor(s) of its progression and new therapeutic approaches to modulate stop or even reverse the disease. Numerous models employing rodent animals have been established in the last decades to investigate the effects of acute and chronic alcohol exposure on the initiation and progression of ALD. Although significant progress has been made in gaining better knowledge on the mechanisms and pathology of ALD, many features of ALD are unknown, and require further investigation, ideally with improved animal models that more effectively mimic human ALD. Although differences in the degree and stages of alcoholic liver injury inevitably exist between animal models and human ALD, the acquisition and translational relevance will be greatly enhanced with the development of new and improved animal models of ALD. | Arantza Lamas-Paz Fengjie Hao Leonard J Nelson Maria Teresa Vázquez Santiago Canals Manuel Gómez del Moral Eduardo Martínez-Naves Yulia A Nevzorova Francisco Javier Cubero | 2018 | World Journal of Gastroenterology2018，24，45： | 26 |
| 2 | Dissecting the molecular pathophysiology of drug-induced liver injury显示文摘Drug-induced liver injury(DILI) has become a major topic in the field of Hepatology and Gastroenterology. DILI can be clinically divided into three phenotypes: hepatocytic, cholestatic and mixed. Although the clinical manifestations of DILI are variable and the pathogenesis complicated, recent insights using improved preclinical models, have allowed a better understanding of the mechanisms that trigger liver damage. In this review, we will discuss the pathophysiological mechanisms underlying DILI. The toxicity of the drug eventually induces hepatocellular damage through multiple molecular pathways, including direct hepatic toxicity and innate and adaptive immune responses. Drugs or their metabolites, such as the common analgesic, acetaminophen, can cause direct hepatic toxicity through accumulation of reactive oxygen species and mitochondrial dysfunction. The innate and adaptive immune responses play also a very important role in the occurrence of idiosyncratic DILI. Furthermore, we examine common forms of hepatocyte death and their association with the activation of specific signaling pathways. | Hui Ye Leonard J Nelson Manuel Gómez del Moral Eduardo Martínez-Naves Francisco Javier Cubero | 2018 | World Journal of Gastroenterology2018，24，13： | 19 |
| 3 | 气象卫星云图的多分辨小波分解及人工神经网络降水估计研究显示文摘采用多分辨小波分析对卫星图象进行预处理 ,在保留其特征信息的同时 ,减小了数据量 ,改善了神经网络训练过程的收敛性能 ,提高了处理速度。采用这一方法根据 GOES- 8的红外亮温图象和气象雷达资料对巴西圣保罗州中部的降水量估计进行了试验 ,取得了良好的效果。 | 李伟钢 Maria C V Ramirez Nelson J Ferreira 石立华 Leonardo D de A Sá | 2000 | 南京气象学院学报2000，23，2： | 13 |
| 4 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 5 | Degree of Hybridization Modeling of a Fuel Cell Hybrid Electric Sport Utility Vehicle显示文摘 | Paul Atwood Stephen Gurski Douglas J Nelson etc | 2001 | SAE paper2001，，： | 2 |
| 6 | Indications and surgical options for small bowel, large bowel and perianal Crohn's disease显示文摘Despite advancements in medical therapy of Crohn's disease(CD), majority of patients with CD will eventually require surgical intervention, with at least a third of patients requiring multiple surgeries. It is important to understand the role and timing of surgery, with the goals of therapy to reduce the need for surgery without increasing the odds of emergency surgery and its associated morbidity, as well as to limit surgical recurrence and avoid intestinal failure. The profile of CD patients requiring surgical intervention has changed over the decades with improvements in medical therapy with immunomodulators and biological agents. The most common indication for surgery is obstruction from stricturing disease, followed by abscesses and fistulae. The risk of gastrointestinal bleeding in CD is high but the likelihood of needing surgery for bleeding is low. Most major gastrointestinal bleeding episodes resolve spontaneously, albeit the risk of re-bleeding is high. The risk of colorectal cancer associated with CD is low. While current surgical guidelines recommend a total proctocolectomy for colorectal cancer associated with CD, subtotal colectomy or segmental colectomy with endoscopic surveillance may be a reasonable option. Approximately 20%-40% of CD patients will need perianal surgery during their lifetime. This review assesses the practice parameters and guidelines in the surgical management of CD, with a focus on the indications for surgery in CD(and when not to operate), and a critical evaluation of the timing and surgical options available to improve outcomes and reduce recurrence rates. | James WT Toh Peter Stewart Matthew JFX Rickard Rupert Leong Nelson Wang Christopher J Young | 2016 | World Journal of Gastroenterology2016，22，40： | 2 |
| 7 | Degradation of Metalaxyl and Folpet by Filamentous Fungi Isolated From Portuguese (Alentejo) Vineyard Soils显示文摘 | M. Rosário Martins Pablo Pereira Nelson Lima Júlio Cruz-Morais | 2013 | Archives of Environmental Contamination and Toxicology2013，，1： | 2 |
| 8 | Microchimerism in recurrent miscarriage显示文摘在怀孕期间,在 microchimerism 的获得的结果,它经久地装在两个接受者坚持的母亲胎儿的房间交换。自然地获得的 microchimerism 可以在怀孕影响母亲胎儿的相互作用。我们进行了研究问一个女人从她的自己的母亲获得了的 microchimerism 是否是可检测的在前或在在有周期性的流产的女人的怀孕期间。胎儿的 microchimerism 也是 assayed。有主要自发的周期性的流产的女人(n= 23 ) 并且控制(n= 31 ) 被学习。Genotyping 为 probands,他们的母亲和胎儿,被进行识别的非分享的多型性和量的聚合酶链反应表现了测量 microchimerismin 外设血 mononuclear 房间。预想比较在周期性的流产题目和控制之间被做,用逻辑回归和 Wilcoxon 等级和。在周期性的流产题目的随后的怀孕的纵的 microchimerism 被描述。向在周期性的流产对控制的 microchimerism 的更低的预想察觉有一个趋势, 6 %对 19 %(1/16 对 6/31, P= 0.2 ) 。在怀孕期间, 3/11 (27 %) 继续了有的周期性的流产题目,出生从他们的自己的母亲有 microchimerism 的察觉,而任何一个继续了流产的二个题目都没有察觉(0/2 ) 。这个起始的数据当可检测时,与周期性的流产在女人从一个女人的自己的母亲建议那 microchimerism,可以不同于控制并且根据随后的怀孕结果。进一步的研究被需要在周期性的流产决定房间类型,数量和 microchimerism 的任何潜在的功能的角色。 | Hilary S Gammill Mary D Stephenson Tessa M Aydelotte J Lee Nelson | 2014 | Cellular & Molecular Immunology2014，11，6： | 2 |
| 9 | Molecular basis of aggression显示文摘 | Randy J Nelson Silvana Chiavegatto | 2001 | Trends in Neurosciences2001，，12： | 2 |
| 10 | Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis显示文摘 | Mary Eapen Vanderson Rocha Guillermo Sanz Andromachi Scaradavou Mei-Jie Zhang William Arcese Anne Sirvent Richard E Champlin Nelson Chao Adrian P Gee Luis Isola Mary J Laughlin David I Marks Samir Nabhan Annalisa Ruggeri Robert Soiffer Mary M Horowitz Eli | 2010 | Lancet Oncology2010，，7： | 2 |
| 11 | Monitoring of aggregates in flowing suspensions显示文摘 | Gregory J Nelson D W | 1986 | Colloids Surfaces1986，18，1： | 2 |
| 12 | Lymphangioleiomyomatosis (LAM) :a review of clinical and morphological features显示文摘 | Ferrans V J Yu ZX Nelson WK | 2000 | J Nippon Med Sch2000，67，5： | 1 |
| 13 | Improved vertical resolution of well logs by resolution matching显示文摘 | Nelson R J Mitchell W K | 1992 | The Log Analyst1992，32，4： | 1 |
| 14 | Simultaneous detection of multiple nucleic acid targets in a geneous format显示文摘 | NELSON N J | 1994 | Biol Chem1994，153，： | 1 |
| 15 | The persistence and degradation of chlorothalonil and chlorpyrifos in a cranberry bog 显示文摘 | Putnam R A Nelson J O Clark J M | 2003 | Agric Food Chem2003，51，： | 1 |
| 16 | Comparison of dermatopharmacokinetic vs clinicial efficacy methods for bioequivalenee assessment of miconazole nitrate vaginal cream, 2% in humans 显示文摘 | PERSHING L K CORLETT J L NELSON J L | 2002 | Pharm Res2002，19，3： | 1 |
| 17 | Visually servoed micropositioning for robotic micromanipulation显示文摘 | VIKRAMADITYA B NELSON B J | 1999 | Microcomputer Application1999，18，1： | 1 |
| 18 | P53 functions as a cell cycle control protein in osteosarcomas,显示文摘 | Kassel J Nelson CE | 1990 | Mol Cell Biol1990，10，11： | 1 |
| 19 | Nodular pulmonary 显示文摘 | Nelson D G Pearsall G F etal | 1997 | G Thorac Cardiovasc Surg1997，114，2： | 1 |
| 20 | Fuel cell systems efficient,flexible energy conversion for the 21st century显示文摘 | Von Spakovsky M R Nelson D J | 2001 | Proc IEEE2001，89，12： | 1 |
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