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| 1 | High-density lipoproteins:an emerging target in the prevention of cardiovascular disease显示文摘高密度的脂蛋白(HDL ) 很好被建立了免于动脉粥样硬化患者的发展心血管的疾病。除了反向的胆固醇运输的提升, HDL 拥有可以在动脉的墙上贡献他们的有益的影响的很多个另外的功能的性质,变得明显。很多令人激动的治疗学的策略被开发了免于动脉粥样硬化患者的发展的那目标 HDL 和它的能力匾。这篇论文将考察 HDL 的功能的性质的提升怎么与确定的疾病在病人禁止动脉粥样硬化患者匾和 stabilises 损害的形成。 | Belinda A Cutri Neil J Hime Stephen J Nicholls | 2006 | Cell Research2006，16，10： | 6 |
| 2 | Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/Ipr mouse model of systemic lupus erythematosus显示文摘热吃惊蛋白质 90 的提高的表示(HSP90 ) 在全身的豺狼座 erythematosus (SLE ) 的肾和浆液被发现了病人和 MRL/Mp-Fas lpr /Fas lpr (MRL/lpr ) 自体免疫的老鼠。如果 HSP90 的抑制将在 MRL/lpr 老鼠减少疾病,我们调查了。在在 vivo 的 vitro,有在 IL-6 的有免疫力刺激的显示出的减少的表示以前的 HSP90 禁止者 Geldanamycin 的 mesangial 房间的预告的处理, IL-12 和号码,我们发现当与 C57BL/6 相比鼠标和 MRL/lpr 鼠标与 HSP90 禁止者 17-DMAG 对待时, HSP90 表示在 MRL/lpr 肾被提高。与 17-DMAG 对待的 MRL/lpr 老鼠显示出减少的 proteinuria 并且减少了浆液 anti-dsDNA 抗体生产。Glomerulonephritis 和 glomerular IgG 和 C3 没被 17-DMAG 的管理显著地在 MRL/lpr 影响。17-DMAG 增加了 CD8 + T 房间,减少的双 negative T 房间,减少 CD4/CD8 比率和减少的小囊的 B 房间。这些研究建议 HSP90 可以在调整 T 房间区别和激活起一个作用并且 HSP90 抑制可以在豺狼座减少发炎。 | Samuel K Shimp III Cristen B Chafin Nicole L Regna Sarah E Hammond Molly A Read David L Caudell Marissa Nichole Rylander Christopher M Reilly | 2012 | Cellular & Molecular Immunology2012，9，3： | 3 |
| 3 | The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) Trial显示文摘 | E Feldmann J L. Wilterdink A Kosinski M Lynn M I. Chimowitz J Sarafin H H. Smith F Nichols J Rogg H J. Cloft L Wechsler J Saver S R. Levine C Tegeler R Adams M Sloan | 2007 | Neurology2007，，24： | 2 |
| 4 | Potential energy curves for the X^1Σ_g^+, B^1△_g and B′~1Σ_g^+ states of C_2 using MRCI and approximate CI methods显示文摘The potential energy curves for the X1Σ g+, B1△g and B′1Σ g+ states of C2 have been studied by using MRC and approximate CI methods, and are benchmarked against the calculations of full configuration in teraction (FCI). The results obtained by MRCI method agree with the FCI very well, and even are accu rate enough to compare other approximate methods as benchmark, when the calculations of FCI ar not feasible. The approximate CI methods mentioned in this paper are reliable for treating chemica problems. | LI AnYang1, WANG YuBin2, DOU YuSheng1,3 & WEN ZhenYi1,2 1 Institute of Bio-information, Chongqing University of Post and Telecommunication, Chongqing 400065, China 2 Institute of Modern Physics, Northwest University, Xi’an 710069, China 3 Department of Physical Sciences, Nicholls State University, PO Box 2022, Thibodaux, LA 70310, U. S. A | 2007 | Science China Chemistry2007，50，5： | 2 |
| 5 | Endothelin-1 activation in pediatric patients undergoing surgical coarctation of the aorta repair显示文摘AIM To determine endothelin-1(ET-1)concentration before and after surgical coarctectomy and evaluate its association with left ventricular geometric change.METHODSA prospective,cohort study of 24 patients aged 2 d to 10years with coarctation of the aorta undergoing surgical repair.A sub-cohort of patients with age<1 mo was classified as'neonates'.Echocardiograms were performed just prior to surgery and in the immediate post-op period to assess left ventricle mass index and relative wall thickness(RWT).Plasma ET-1 levels were assessed at both time points.Association between ET-1 levels and ventricular remodeling was assessed.RESULTSPatients<1 year demonstrated higher pre-op ET-1 than post-op(2.8 pg/m L vs 1.9 pg/m L,P=0.02).Conversely,patients>1 year had no change in ET-1 concentration before and after surgery(1.1 vs 1.4,NS).Pre-op,patients<1 year demonstrated significantly higher ET-1 than older children(2.8 vs 1.1,P=0.001).Post-op there was no difference between the age groups(1.9 vs 1.4,NS).Neither RWT nor left ventricle mass index(LVMI)varied from pre-op to post-op.The subset of neonates showed a strong positive correlation between pre-op ET-1 and RWT(r=0.92,P=0.001).Patients with ET-1>2 pg/m L preop demonstrated higher LVMI(65.7 g/m^(2.7) vs 38.5 g/m^(2.7),P=0.004)and a trend towards higher RWT(45%vs39%,P=0.07)prior to repair than those with lower ET-1concentration.CONCLUSIONET-1 concentration is significantly variable in the perioperative period surrounding coarctectomy.Older children and infants have different responses to surgical repair suggesting different mechanisms of activation. | Benjamin Steven Frank Tracy T Urban Suhong Tong Courtney Cassidy Max B Mitchell Christopher S Nichols Jesse A Davidson | 2017 | World Journal of Cardiology2017，9，12： | 2 |
| 6 | Peripheral blood mononuclear cells acquire myofibroblast characteristics in granulation tissue显示文摘 | Moncada GA Nichols CE | 2005 | J Vasc Res2005，42，2： | 1 |
| 7 | Impact of complex geneticvariation in COMT on human brain function显示文摘 | Meyer-Lindenberg A Nichols T Callicott JH | 2006 | Mol Psychiatry2006，797，： | 1 |
| 8 | A honey bee odorant receptor for the queen substance 9-oxo-2-decenoic acid显示文摘 | Wanner K W Nichols A S Walden K K | 2007 | Proc Natl Acad Sci2007，104，14： | 1 |
| 9 | Optimization of the activated sludge process for the biological removal of phosphorus 显示文摘 | Osbron D W Nicholls H A | 1998 | Prog Water Technol1998，10，12： | 1 |
| 10 | Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb 显示文摘 | Li Yan Nichols M A Shay J W | 1994 | Cancer Res1994，54，23： | 1 |
| 11 | Intrauterine lidocaine infusion for pain management in first-trimester abortions显示文摘 | EDELMAN A NICHOLS M D LECLAIR C | 2004 | Obstet Gynecol2004，103，6： | 1 |
| 12 | 查看详情显示文摘 | Renoncourt A Bauduin P Nicholl E Touraud D Verbavatz J.M Dubois M Drechsler M Kunz W | | 0，，： | 1 |
| 13 | Prevention of intra-ab- dominal abscess following laparoscopic appendicectomy for perforated ap- pendicitis : A prospective study显示文摘 | A Hussain H Mahmood J Nicholls | 2008 | International Journal of Surgery2008，4，6： | 1 |
| 14 | Swine manure characterization as affected by environmental-temperature, dietary level intake, and dietary-fat addition显示文摘 | Clanton C J Nichols D A Moser R L | 1991 | Transactions of the ASAE1991，34，： | 1 |
| 15 | Swine models of type 2 diabetes mellitus : insulin resistance, glucose tolerance, and cardiovascular complications 显示文摘 | Bellinger D A Merricks E P Nichols T C | 2006 | ILAR J2006，47，3： | 1 |
| 16 | Intermittent Detonation as a ThrustProducing Mechanism 显示文摘 | Nicholl J A Wilkinson H R Morrison R B | 1957 | Jet Propulsion1957，27，： | 1 |
| 17 | Nitric oxide synthase distribution in tile rat intestine:a histochemical analysis 显示文摘 | Nichols K Staines W Krantis A | 1993 | Gastroenterology1993，105，6： | 1 |
| 18 | B-type natriuretic peptides and ejection fraction for prognosis after myocardial infarction显示文摘 | Richards A M Nicholls M G Espiner E A | 2003 | Circulation2003，107，22： | 1 |
| 19 | Four percent intrauterine lidocaine infusion for pain management in first-trimester abortions显示文摘 | EDELMAN A NICHOLS M D LECLAIR C | 2006 | Obstet Gynecol2006，107，21： | 1 |
| 20 | A subset of ES-cell-derived neural cells marked by gene targeting显示文摘 | Xian HQ Mc Nichols E Stclair A | 2003 | Stem Cells2003，21，6： | 1 |
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