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| 1 | Empagliflozin alleviates podocytopathy and enhances glomerular nephrin expression in db/db diabetic mice显示文摘BACKGROUND Modern guidelines recommend sodium-glucose cotransporter-2(SGLT2)inhibitors as the preferred antihyperglycemic agents for patients with type 2 diabetes and chronic kidney disease.However,the mechanisms underlying the renal protective effect of SGLT2 inhibitors are not fully understood.structure of podocytes and nephrin expression in glomeruli in db/db diabetic mice.METHODS We treated 8-wk-old male db/db mice with EMPA(10 mg/kg/d)or vehicle for 8 wk.Age-matched male db/+mice were included as non-diabetic controls.Parameters of body composition,glycemic and lipid control,and plasma concentrations of leptin,insulin and glucagon were assessed.We evaluated renal hypertrophy as kidney weight adjusted to lean mass,renal function as plasma levels of creatinine,and albuminuria as the urinary albumin-to-creatinine ratio(UACR).Renal structures were studied by light and transmission electron microscopy with a focus on mesangial volume and podocyte structure,respectively.Glomerular nephrin and transforming growth factor beta(TGF-β)were assessed by immunohistochemistry.RESULTS Severe obesity and hyperglycemia developed in db/db mice prior to the start of the experiment;increased plasma concentrations of fructosamine,glycated albumin,cholesterol,leptin,and insulin,and elevated UACR were detected.Mesangial expansion,glomerular basement membrane thickening,and increased area of TGF-βstaining in glomeruli were revealed in vehicle-treated mice.Podocytopathy was manifested by effacement of foot processes;nephrin-positive areas in glomeruli were reduced.EMPA decreased the levels of glucose,fructosamine and glycated albumin,UACR,kidney hypertrophy,mesangial expansion,glomerular basement membrane thickening,and glomerular TGF-βstaining,alleviated podocytopathy and restored glomerular staining of nephrin.CONCLUSION These data indicate that EMPA attenuates podocytopathy in experimental diabetic kidney disease.The anti-albuminuric effect of EMPA could be attributed to mitigation of podocyte injury and enhancement of nephrin expression. | Vadim V Klimontov Anton I Korbut Iuliia S Taskaeva Nataliya P Bgatova Maksim V Dashkin Nikolai BOrlov Anna S Khotskina Evgenii L Zavyalov Thomas Klein | 2020 | World Journal of Diabetes2020，11，12： | 2 |
| 2 | Fragmental approach in QSPR显示文摘 | NIKOLAI S Z VLADIMIR A P | 2002 | J Chem Inf Comput Sci2002，42，： | 1 |
| 3 | Obstetric antiphospholipid syndrome显示文摘 | Claudio Galarza-Maldonado Maria R. Kourilovitch Oscar M. Pérez-Fernández Mariana Gaybor Christian Cordero Sonia Cabrera Nikolai F. Soroka | 2011 | Autoimmunity Reviews2011，，4： | 1 |
| 4 | Comparison of magnetic parameters of urban atmospheric particulate matter with pollution and meteorologicaldata显示文摘 | Adrian R M Jtirgen M Nikolai P | 2001 | Atmospheric Environment2001，35，26： | 1 |
| 5 | Obstetric antiphospholipid syndrome显示文摘 | Claudio Galarza-Maldonado Maria R. Kourilovitch Oscar M. Pérez-Fernández Mariana Gaybor Christian Cordero Sonia Cabrera Nikolai F. Soroka | 2011 | Autoimmunity Reviews2011，，4： | 1 |
| 6 | Age and growth of pike(Esox lucius) in Chivyrkui Bay,Lake Baikal显示文摘 | Randall W O Nikolai M P | 2000 | Great Lakes Res2000，26，2： | 1 |
| 7 | Toward efficient blue-emitting thiol-capped ZnI - Cd Se nanocrystals 显示文摘 | Vladimir L Alexei P Nikolai G | 2008 | Journal of Materials Chemistry2008，18，42： | 1 |
| 8 | Age and growth of pike (Esox lucius) in Chivyrkui Bay, Lake Baikal 显示文摘 | Randall W O Nikolai M P | 2000 | Great Lakes Res2000，26，2： | 1 |
| 9 | Random sums of exchangeable variables and actuarial applications 显示文摘 | NIKOLAI K DELHI P A | 2008 | Insurance: Mathematics and Economics2008，，42： | 1 |
| 10 | Allergic Rhinitis and Its Impact on Asthma in Asia Paciflcand the ARIA Update 2008显示文摘 | Ruby P Chaweewan B Nikolai K et a/ | 2012 | WAO Journal2012，5，： | 1 |
| 11 | Granulocyte colony-stimulating factor inhibits the mitochondria-dependent activation of caspase-3 in neutrophils显示文摘 | Nikolai A Maianski Frederik P | 2002 | Blood2002，99，： | 1 |
| 12 | Iron-deficiency responses in cereal seedlings显示文摘 | NIKOLAI P B | 2007 | Jour-nal of Plant Nutrition2007，30，： | 1 |
| 13 | Direct measurement of lateral capillary forces显示文摘 | ORLIN D V NIKOLAI D D VESSELIN N P | 1993 | Langmuir1993，9，12： | 1 |
| 14 | The nickel - catalyzed sonogashira - hagihara reaction 显示文摘 | Beletskaya Irina P Latyshev Gennadij V Lukashev Nikolai V | 2003 | Tetrahedron Letters2003，44，27： | 1 |
| 15 | Copper corrosion in mildly alkaline water with the disinfectant monochloramine 显示文摘 | Zhang X H Simo O P Nikolai K | 2002 | Corrosion Science2002，44，： | 1 |
| 16 | Identification of rifampin-resi- stant mycobacterium tuberculosis strains by hybridization,PCR, and ligase detection reaction on oligonucleotide microchips显示文摘 | Vladimir M Sergey L Dimitry G Alexander S Boris S Nikolai C Olga S Olga I Arkadii M Vitalii L Mikhall V Mikhail P Larisa C Vladislav E Alexander Z Andrei M | 2001 | Journal of Clinical Microbiology2001，39，7： | 1 |
| 17 | Slip boundary conditions for shear flow of polymer melts past atomically flat surfaces 显示文摘 | Anoosheh N Nikolai V P | 2008 | Physical Review2008，77，4： | 1 |
| 18 | Identification of rifampin-resi-stant mycobacterium tuberculosis strains by hybridization,PCR,and ligase detection reaction on oligonucleotide microchips显示文摘 | Vladimir M Sergey L Dimitry G Alexander S Boris S Nikolai C Olga S Olga I Arkadii M Vitalii L Mikhall V Mikhail P Larisa C Vladislav E Alexander Z Andrei M | 2001 | Journal of Clinical Microbiology2001，，39： | 1 |
| 19 | Explosive threestage launcher to accelerate metal plates to velocities more than 10 km/s显示文摘 | Bat'kov Yuri V Kovalev Nikolai P | 1997 | Int J Impact Engng1997，20，： | 1 |
| 20 | Identification of an O-linked repetitive glycan chain of the polar flagellum flagellin of Azospirillum brasilense Sp7 显示文摘 | Alexei Ye Belyakov Gennady L Burygin Nikolai P Arbatsky | 2012 | Carbohydrate Research2012，361，： | 1 |
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