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您的检索式：作者名="Norbert Hüser"
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| 1 | Heparin-induced thrombocytopenia in solid organ transplant recipients: The current scientific knowledge显示文摘Exposure to heparin is associated with a high incidence of immunization against platelet factor 4(PF4)/heparin complexes. A subgroup of immunized patients is at risk of developing heparin-induced thrombocytopenia(HIT), an immune mediated prothrombotic adverse drug effect. Transplant recipients are frequently exposed to heparin either due to the underlying end-stage disease, which leads to listing and transplantation or during the transplant procedure and the perioperative period. To review the current scientific knowledge on antiheparin/PF4 antibodies and HIT in transplant recipients a systematic Pub Med literature search on articles in English language was performed. The definition of HIT is inconsistent amongst the publications. Overall, six studies and 15 case reports have been published on HIT before or after heart, liver, kidney, and lung transplantation, respectively. The frequency of seroconversion for anti-PF4/heparin antibodies ranged between 1.9% and 57.9%. However, different methods to detect anti-PF4/heparin antibodies were applied. In none of the studies HIT-associated thromboembolic events or fatalities were observed. More importantly, in patients with a history of HIT, reexposure to heparin during transplantation was not associated with thrombotic complications. Taken together, the overall incidence of HIT after solid organ transplantation seems to be very low. However, according to the current knowledge, cardiac transplant recipients may have the highest risk to develop HIT. Different alternative suggestions for heparin-free anticoagulation have been reported for recipients with suspected HIT albeit no official recommendations on management have been published for this special collective so far. | Volker Assfalg Norbert Hüser | 2016 | World Journal of Transplantation2016，6，1： | 2 |
| 2 | Effect of p120 Catenin Silencing on Biological Behaviors of PANC-1 Cells显示文摘This study examined the possible role of p120ctn in the pathogenesis and development of pan-creatic cancer.PANC-1 cells,a kind of human pancreatic carcinoma cell line,were cultured in this study.p120ctn was immunocytochemically detected in PANC-1 cells.The recombinant lentivirus vector was constructed to knock down the p120ctn expression of PANC-1 cells.Real-time quantitative PCR (RQ-PCR) and Western blotting were used to determine the expression of p120ctn and E-cadherin in PANC-1 cells after p120ctn knockdown.The adhesion,invasion and migration capacity of PANC-1 cells after p120ctn knockdown was detected by cell adhesion,invasion and migration assays.Cell growth was measured by the MTT method.Cell cycle and apoptosis were analyzed by fluorescence-activated cell sorting.The results showed that p120ctn knockdown led to significantly down-regulated E-cadherin and a reduced cell-to-cell adhesion ability in PANC-1 cells.shRNA-mediated knockdown of p120ctn reduced invasion and migration capacity of PANC-1 cells,inhibited cell growth,caused a significant decrease in the percentage of cells in G1,an increase in S,and promoted apoptosis of PANC-1 cells.It was concluded that p120ctn plays a pivotal role in the proliferation and metastasis of pancreatic carcinoma,suggesting that p120ctn is a novel target for pancreatic carcinoma treatment. | 程张军 Volker Assfag 石欣 林士波 夏江燕 杨平华 Norbert Hüser 沈锋 | 2012 | Journal of Huazhong University of Science and Technology(Medical Sciences)2012，32，5： | 0 |
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