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| 1 | Cytoprotective role of heme oxygenase-1 and heme degradation derived end products in liver injury显示文摘The activation of heme oxygenase-1(HO-1) appears to be an endogenous defensive mechanism used by cells to reduce inflammation and tissue damage in a number of injury models. HO-1, a stress-responsive enzyme that catabolizes heme into carbon monoxide(CO), biliverdin and iron, has previously been shown to protect grafts from ischemia/reperfusion and rejection.In addition, the products of the HO-catalyzed reaction, particularly CO and biliverdin/bilirubin, have been shown to exert protective effects in the liver against a number of stimuli, as in chronic hepatitis C and in transplanted liver grafts. Furthermore, the induction of HO-1 expression can protect the liver against damage caused by a number of chemical compounds. More specifically, the CO derived from HO-1-mediated heme catabolism has been shown to be involved in the regulation of inflammation; furthermore, administration of low concentrations of exogenous CO has a protective effect against inflammation. Both murine and human HO-1 deficiencies have systemic manifestations associated with iron metabolism, such as hepatic overload(with signs of a chronic hepatitis) and iron deficiency anemia(with paradoxical increased levels of ferritin).Hypoxia induces HO-1 expression in multiple rodent,bovine and monkey cell lines, but interestingly, hypoxia represses expression of the human HO-1 gene in a variety of human cell types(endothelial cells, epithelial cells, T cells). These data suggest that HO-1 and CO are promising novel therapeutic molecules for patients with inflammatory diseases. In this review, we present what is currently known regarding the role of HO-1 in liver injuries and in particular, we focus on the implications of targeted induction of HO-1 as a potential therapeutic strategy to protect the liver against chemically induced injury. | Clarice Silvia Taemi Origassa Niels Olsen Saraiva Cmara | 2013 | World Journal of Hepatology2013，5，10： | 17 |
| 2 | Intestinal barrier: A gentlemen's agreement between microbiota and immunity显示文摘Our body is colonized by more than a hundred trillion commensals, represented by viruses, bacteria and fungi. This complex interaction has shown that the microbiome system contributes to the host's adaptation to its environment, providing genes and functionality that give flexibility of diet and modulate the immune system in order not to reject these symbionts. In the intestine,specifically, the microbiota helps developing organ structures, participates of the metabolism of nutrients and induces immunity. Certain components of the microbiota have been shown to trigger inflammatory responses, whereas others, anti-inflammatory responses.The diversity and the composition of the microbiota,thus, play a key role in the maintenance of intestinal homeostasis and explain partially the link between intestinal microbiota changes and gut-related disorders in humans. Tight junction proteins are key molecules for determination of the paracellular permeability. In the context of intestinal inflammatory diseases, the intestinal barrier is compromised, and decreased expression and differential distribution of tight junction proteins is observed. It is still unclear what is the nature of the luminal or mucosal factors that affect the tight junctionproteins function, but the modulation of the immune cells found in the intestinal lamina propria is hypothesized as having a role in this modulation. In this review,we provide an overview of the current understanding of the interaction of the gut microbiota with the immune system in the development and maintenance of the intestinal barrier. | Andrea Moro Caricilli Angela Castoldi Niels Olsen Saraiva Cmara | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，1： | 11 |
| 3 | Oxidation of cyclohexane promoted by and 显示文摘 | Salomao G C Olsen M H N Drago V | 2007 | Catal Commun2007，8，1： | 1 |
| 4 | An Efficient Power Management Scheme for Mobile Devices显示文摘 | Olsen C M Narayanaswami C | 2006 | Mobile Computing2006，5，7： | 1 |
| 5 | From transaction cost to transaction value analysis: Implications for the study of interorganizational strategies显示文摘 | Zajac E J and Olsen C P | 1993 | Journal of Management Studies1993，30，1： | 1 |
| 6 | An empirical analysis of entrepreneursbip and performance in the restaurant industry显示文摘 | Tse E C Olsen M D | 1999 | Journal of Hospitality & Tourism Research1999，23，4： | 1 |
| 7 | The emergence of novel swine influenza viruses in North America显示文摘 | OLSEN C W | 2002 | Virus Research2002，85，2： | 1 |
| 8 | Estimation of available phosphorus in soils by extraction with sodium bicarbonate 显示文摘 | Olsen S R Cole C V Watanabe F S | 1954 | USDA Circ1954，939，： | 1 |
| 9 | Influence of shielding gas type in high power Nd:YAG laser welding 显示文摘 | Bagger C Olsen F | 1994 | International Journal for the Joining of Materials1994，6，2： | 1 |
| 10 | An enhancer activates the pig lactase phlorizin hydrolase promoter in intestinal Ceils 显示文摘 | Troclsen J T Mitchelmore C Olsen J | 2003 | Gene2003，305，： | 1 |
| 11 | Using a knowledge utilization framework to explore how findings from one study can be applied to other nursing contexts显示文摘 | Olsen PR Bradbury-Jones C | 2013 | Int Nurs Bey2013，60，3： | 1 |
| 12 | Estrogen-like properties of brominated analogs of bisphenol A in the MCF-7 human breast cancer cell line显示文摘 | Samuelsen M Olsen C Holme JA | 2004 | Cell Biology and Toxicology2004，17，： | 1 |
| 13 | The endogenous GL3,but not EGL3,gene is necessary for anthocyanin acculmulation as induced by nitrogen depletion in Arabidopsis rosette stage leaves显示文摘 | FEYISSA D N LOVDAL T OLSEN K M SLIMESTAD R LILLO C | 2009 | Planta2009，230，： | 1 |
| 14 | Sketch-based modeling:a survey显示文摘 | Olsen L Samavati F F Sousa M C | 2009 | Computers & Graphics2009，33，1： | 1 |
| 15 | The influence of gender on theperception and response to investment risk:the case ofprofessional investors显示文摘 | Olsen R A Cox C M | 2001 | Journal of Psychology andFinancial Markets2001，2，： | 1 |
| 16 | Cloning of a Salmo salar interleukin-1 receptor-like cDNA显示文摘 | Subramaniam S Stansberg C Olsen L | 2002 | Dev Comp Immunol2002，26，5： | 1 |
| 17 | Genetic char-acterization of an H1N2influenza virus isolated from apig in Indiana显示文摘 | Karasin A I Olsen C W Anderson G A | 2000 | J Clin Microbiol2000，38，6： | 1 |
| 18 | Probability of detecting Porcine reproductive and respiratory syndrome virus infection using pen-based swine oral fluid specimens as a function of within-pen prevalence显示文摘 | Olsen C Wang C Christopher-Hennings J | 2013 | Journal of Veterinary Diagnostic Investigation2013，25，3： | 1 |
| 19 | New drugs for rheumatoid arthritis显示文摘 | OLSEN N J STEIN C M | 2004 | N Engl J Med2004，350，21： | 1 |
| 20 | Explanation for Low-efficiency CuE O Schottky-barrier Solar Cells显示文摘 | Olsen L C Bohara RC Urie M W | 1979 | Applied Physics Letter1979，34，1： | 1 |
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