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| 1 | Hepatocellular carcinoma surveillance:An evidence-based approach显示文摘Hepatocellular carcinoma(HCC) makes up 75%-85% of all primary liver cancers and is the fourth most common cause of cancer related death worldwide. Chronic liver disease is the most significant risk factor for HCC with 80%-90% of new cases occurring in the background of cirrhosis. Studies have shown that early diagnosis of HCC through surveillance programs improve prognosis and availability of curative therapies. All patients with cirrhosis and high-risk hepatitis B patients are at risk for HCC and should undergo surveillance. The recommended surveillance modality is abdominal ultrasound(US) given that it is cost effective and noninvasive with good sensitivity. However, US is limited in obese patients and those with non-alcoholic fatty liver disease(NAFLD). With the current obesity epidemic and rise in the prevalence of NAFLD, abdominal computed tomography or magnetic resonance imaging may be indicated as the primary screening modality in these patients. The addition of alpha-fetoprotein to a surveillance regimen is thought to improve the sensitivity of HCC detection.Further investigation of serum biomarkers is needed. Semiannual screening is the suggested surveillance interval. Surveillance for HCC is underutilized and low adherence disproportionately affects certain demographics such as nonCaucasian race and low socioeconomic status. | Patrick S Harris Ross M Hansen Meagan E Gray Omar I Massoud Brendan M McGuire Mohamed G Shoreibah | 2019 | World Journal of Gastroenterology2019，25，13： | 31 |
| 2 | Role of vitamins in gastrointestinal diseases显示文摘A tremendous amount of data from research was published over the past decades concerning the roles of different vitamins in various gastrointestinal diseases.For instance,most vitamins showed an inverse relationship with the risk of colorectal carcinoma as well as other malignancies like gastric and esophageal cancer in observational trials,however interventional trials failed to prove a clear beneficial preventive role.On the other hand,more solid evidence was obtained from high quality studies for a role of certain vitamins in specific entities.Examples for this include the therapeutic role of vitamin E in patients with nonalcoholic steatohepatitis,the additive role of vitamins B12 and D to the standard therapy of chronic hepatitis C virus,the role of vitamin C in reducing the risk of gallstones,the positive outcome with vitamin B12 in patients with aphthous stomatitis,and the beneficial effect of vitamin D and B1 in patients with inflammatory bowel disease.Other potential uses are yet to be elaborated,like those on celiac disease,pancreatic cancer,pancreatitis,cholestasis and other potential fields.Data from several ongoing interventional trials are expected to add to the current knowledge over the coming few years.Given that vitamin supplementation is psychologically accepted by patients as a natural compound with relative safety and low cost,their use should be encouraged in the fields where positive data are available. | Omar A Masri Jean M Chalhoub Ala I Sharara | 2015 | World Journal of Gastroenterology2015，21，17： | 8 |
| 3 | Incidence and risk factors for the development of anemia following gastric bypass surgery显示文摘AIM:To evaluate the incidence and risk factors for the development of anemia after RouxenY gastric bypass (RYGB).METHODS: A retrospective analysis of patients undergoing RYGB from January 2003 to November 2007 was performed. All patients had a preoperative body mass index > 40 kg/m2. A total of 206 patients were evaluated. All patients were given daily supplements of ferrous sulfate tablets for 2 wk following their operation. Hematological and metabolic indices were routinely evaluated following surgery. Patients were followed for a minimum of 86 wk.RESULTS: There were 41 males and 165 females with an average age of 40.8 years. 21 patients (10.2%) developed postoperative anemia and 185 patients (89.8%) did not. Anemia was due to iron deficiency in all cases. The groups had similar demographics, surgical procedure and comorbidities. Menstruation (P = 0.02) and peptic ulcer disease (P = 0.01) were risk factors for the development of postoperative anemia.CONCLUSION: Iron deficiency anemia is frequent. RYGB surgery compounds occult blood loss. Increased ferrous sulfate supplementation may prevent iron depletion in populations at increased risk. | Dimitrios V Avgerinos Omar H Llaguna Matthew Seigerman Amanda J Lefkowitz I Michael Leitman | 2010 | World Journal of Gastroenterology2010，16，15： | 6 |
| 4 | Split-dose menthol-enhanced PEG vs PEG-ascorbic acid for colonoscopy preparation显示文摘AIM:To compare the efficacy and palatability of 4L polyethylene glycol electrolyte(PEG)plus sugar-free menthol candy(PEG+M)vs reduced-volume 2 L ascorbic acid-supplemented PEG(Asc PEG).METHODS:In a randomized controlled trial setting,ambulatory patients scheduled for elective colonoscopy were prospectively enrolled.Patients were randomized to receive either PEG+M or Asc PEG,both splitdosed with minimal dietary restriction.Palatability was assessed on a linear scale of 1 to 5(1=disgusting;5=tasty).Quality of preparation was scored by assignment-blinded endoscopists using the modified Aronchick and Ottawa scales.The main outcomes were the palatability and efficacy of the preparation.Secondary outcomes included patient willingness to retake the same preparation again in the future and completion of the prescribed preparation.RESULTS:Overall,200 patients were enrolled(100patients per arm).PEG+M was more palatable than Asc PEG(76%vs 62%,P=0.03).Completing the preparation was not different between study groups(91%PEG+M vs 86%Asc PEG,P=0.38)but more patients were willing to retake PEG+M(54%vs 40%respectively,P=0.047).There was no significant difference between PEG+M vs Asc PEG in adequate cleansing on both the modified Aronchick(82%vs77%,P=0.31)and the Ottawa scale(85%vs 74%,P=0.054).However,PEG+M was superior in the left colon on the Ottawa subsegmental score(score0-2:94%for PEG+M vs 81%for Asc PEG,P=0.005)and received significantly more excellent ratings than Asc PEG on the modified Aronchick scale(61%vs 43%,P=0.009).Both preparations performed less well in afternoon vs morning examinations(inadequate:29%vs 15.2%,P=0.02).CONCLUSION:4 L PEG plus menthol has better palatability and acceptability than 2 L ascorbic acidPEG and is associated with a higher rate of excellentpreparations;Clinicaltrial.gov identifier:NCT01788709. | Ala I Sharara Ali H Harb Fayez S Sarkis Jean M Chalhoub Rami Badreddine Fadi H Mourad Mahmoud Othman Omar Masri | 2015 | World Journal of Gastroenterology2015，21，6： | 2 |
| 5 | 腹腔镜与开腹全结肠系膜切除术治疗右半结肠癌的比较显示文摘目的:全结肠系膜切除术(complete mesocolic excision,CME)应用于结肠癌治疗中越来越受欢迎。本研究目的是比较腹腔镜CME(laparoscopic complete mesocolic excision,LCME)和开腹CME(open complete mesocolic excision,OC⁃ME)在右半结肠癌治疗中的可行性、安全性、围手术期并发症以及患者的预后方面的差异。方法:这是一项前瞻性研究,纳入了2012年1月至2019年12月在Assiut大学南方埃及肿瘤中心接受根治性CME右半结肠切除术,术后病理证实为Ⅱ期或Ⅲ期的结肠癌患者作为研究对象。根据手术入路方式的不同将患者分为LCME组(n=48)或OCME组(n=48)。结果:LCME组的平均手术时间明显长于OCME组,平均术中出血量更少。LCME组中有4例(8.3%)患者中转开腹。与OCME组相比,LCME组获取淋巴结数目更多【(39.81±16.74)vs.(32.65±12.28),P=0.010】,第一次排气时间更短,术后进流质饮食和恢复正常饮食的时间更早,术后住院时间更短。LCME组术后并发症发生率为14.7%,略低于OC⁃ME组的27.2%(P=0.252)。LCME组的3年总生存率与OCME组相似(78.2%vs.63.2%,P=0.423)。LCME组3年无疾病进展生存率为74.5%,高于OCME组的60.0%,但差异无统计学意义(P=0.266)。结论:对于专科外科医师,LCME在技术上是安全可行的。对于Ⅱ期或Ⅲ期结肠癌患者,LCME的长期肿瘤预后与OCME相当。 | 杜斌斌 姜雷 ZEDAN A ELSHIEKH E OMAR M I | 2021 | 结直肠肛门外科2021，27，3： | 2 |
| 6 | Solitary rectal ulcer syndrome presenting as polypoid mass lesions in a young girl显示文摘Solitary rectal ulcer syndrome (SRUS) is a rare condition in children. We report a case of SRUS in an 8-year old Saudi girl who presented with recurrent rectal bleeding,intermittent mucosal prolapse,and passage of mucus per rectum. Colonoscopy revealed multiple polypoid mass lesions with histopathological features of SRUS. The polypoid variant of SRUS is very rare in children and may be confused with rectal malignant or inflammatory conditions. | Omar I Saadah Maram S Al-Hubayshi Ahmad T Ghanem | 2010 | World Journal of Gastrointestinal Oncology2010，2，8： | 2 |
| 7 | Identification of the regeneration potential of embryo derived calli from various indica rice varieties 显示文摘 | Seraj Z I Islan Z Omar Faruque M | 1997 | Plant Cell Tissue and Organ Culture1997，48，： | 1 |
| 8 | Anti-cyclic citrullinated peptide (anti-CCP) antibody in juvenile idiopathic arthritis (JIA):correlations with discase activity and scverity of joint damage (a multicenter trial)显示文摘 | Omar A Abo-Elyoun I Hussein H | | 0，，： | 1 |
| 9 | Convenient, room-temperature, amine-assisted routes to metal sulfides, sele-nides and tellurides显示文摘 | Dusastre V’Omar B Parkin I P | 1997 | J Chem SocfDalton Trans1997，，19： | 1 |
| 10 | Novel benzothiazole-2- carbomates as potential anthelmintieagents显示文摘 | Omar A M M E Ahmed I C | 2007 | Alexandria J of Pharm Scien2007，21，2： | 1 |
| 11 | Systematic re- view of oncological outcomes following surgical man agement of localised renal cancer显示文摘 | MacLennan S Imanmra M Lapitan M C Omar M I Lain T B Hilvano-Cabungcal A M | 2012 | Eur Urol2012，61，97： | 1 |
| 12 | Supercritical carbon dioxide (SC-CO2) extraction and fractionation of palm kernel oil from palm kernel as cocoa butter replacers blend显示文摘 | Zaidul I S M Norulaini N A N Omar A K M | | 0，，： | 1 |
| 13 | Blending of supercritical carbon dioxide(SC-CO2)extracted palm kernel oil fractions and palm oil to obtain cocoa butter replacers显示文摘 | Zaidul I S M Nik Norulaini M A Mohd Omar A K | 2007 | Journal of Food Engineering2007，78，4： | 1 |
| 14 | Oral nifedipine versus intravenous labetalol for acute blood pressure control in hypertensive emergencies of pregnancy:a randomised trial显示文摘 | Raheem I A Saaid R Omar S Z | 2012 | BJOG:An International Journal of Obstetrics&Gynaecology2012，119，1： | 1 |
| 15 | False-positive F-18 FDG uptake in PET/CT studies in pediatric patients with abdominal Burkitt' s lymphoma显示文摘 | Riad R Omar W Sidhom I | 2010 | Nucl Med Commun2010，31，3： | 1 |
| 16 | Assessment of sic Gy lated high-dose partial-body irradiation by PCC -R assay 显示文摘 | Ivonne Romero Omar Garcia Ana I | 2013 | Journal of Radiation Research2013，54，5： | 1 |
| 17 | Effect of nickel oxide doping on the kinetics and mechanism of iron oxide reduction 显示文摘 | Nasr M I Omar A A Khedr M H | 1995 | The Iron and Steel Institute of Japan1995，35，9： | 1 |
| 18 | MRI findings in bipartite patella显示文摘 | Kavanagh EC Zoga A Omar I | | 0，，3： | 1 |
| 19 | Synergism of cellulase enzymes in mixed culture solid substrate fermentation 显示文摘 | Massadeh M I Yusoff W M W Omar O | 2001 | Biotechnology Letters2001，23，21： | 1 |
| 20 | Analysis of Solid-State Re- duction of Iron Ore From a Couple of Experimental Measurements显示文摘 | Nasr M I Omar A A Khadr M H | 1994 | Scandinavian Journal of Metallurgy1994，23，3： | 1 |
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