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| 1 | The significance of clinical practice guidelines on adult varicocele detection and management显示文摘精索静脉曲张是男因素不孕的最普通的可改正的病原学。然而,精索静脉曲张的察觉和管理没被标准化。这在男不孕上关于精索静脉曲张的效果导致了争论的十年,随后,是否修理,导致改进富饶地位。调查精索静脉曲张和 varicocelectomy 的角色的证据的当前的身体弱、冲突。AUA 和 ASRM 拿的位置建议有不够的结果数据支持基于证据的指南,引用过去常提供建议通常具有低优秀水平的电流的证据。在另一方面, EAU 指南为临床上摸得出的精索静脉曲张的管理给水平证据的 1a,与低于正常的精液分析和有的不同 unexplained 富饶联系了。除与临床的精索静脉曲张察觉和管理帮助以外,临床的实践意见陈述和指南试图指导并且加强未来研究的基础结构。我们在实践与他们的申请的焦点在精索静脉曲张和管理察觉考察意见陈述和指南的当前的地位。 | Anand Shridharani Ryan C Owen Osama O Elkelany Edward D Kim | 2016 | Asian Journal of Andrology2016，18，2： | 11 |
| 2 | Oxidative stress modulation in hepatitis C virus infected cells显示文摘Hepatitis C virus(HCV) replication is associated with the endoplasmic reticulum, where the virus can induce cellular stress. Oxidative cell damage plays an important role in HCV physiopathology. Oxidative stress is triggered when the concentration of oxygen species in the extracellular or intracellular environment exceeds antioxidant defenses. Cells are protected and modulate oxidative stress through the interplay of intracellular antioxidant agents, mainly glutathione system(GSH) and thioredoxin; and antioxidant enzyme systems such as superoxide dismutase, catalase, GSH peroxidase, and heme oxygenase-1. Also, the use of natural and synthetic antioxidants(vitamin C and E, N-acetylcysteine, glycyrrhizin, polyenylphosphatidyl choline, mitoquinone, quercetin, S-adenosylmethionine and silymarin) has already shown promising results as co-adjuvants in HCV therapy. Despite all the available information, it is not known how different agents with antiviral activity can interfere with the modulation of the cell redox state induced by HCV and decrease viral replication. This review describes an evidence-based consensus on molecular mechanisms involved in HCV replication and their relationship with cell damage induced by oxidative stress generated by the virus itself and cell antiviral machinery. It also describes some molecules that modify the levels of oxidative stress in HCV-infected cells. | Sonia A Lozano-Sepulveda Owen L Bryan-Marrugo Carlos Cordova-Fletes Maria C Gutierrez-Ruiz Ana M Rivas-Estilla | 2015 | World Journal of Hepatology2015，7，29： | 6 |
| 3 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 4 | 腔内介入治疗血管性勃起功能障碍显示文摘过去一个世纪里,勃起功能障碍(ED)的治疗一直是一件引人关注的事情,涉及到泌尿、心血管以及手术领域的多个学科。随着ED与心血管疾病的相关性被充分证实,血管造影技术已被用来鉴别血管性阳痿。由于腔内血管药物洗脱支架植入术在治疗冠状动脉疾病获得成功,采用该技术来治疗血管性ED已激起了医务人员的浓厚兴趣。最近报道了针对阴茎流入血管狭窄的男性,植入药物洗脱支架绕过病变处动脉已获得了较高的成功率。同样,血管内栓塞治疗静脉闭塞功能障碍也取得了惊人的手术成功率。然而,查阅文献发现动脉介入只推荐应用于治疗年轻的孤立性血管损伤的患者,通常为那些先前经历过创伤的患者。该手术的短期功能恢复没有达到最佳,长期疗效也有待进一步观察。总之,用微创方法治疗勃起功能障碍的希望仍然存在,但是在获得普遍认可之前仍需要进一步的研究。 | Edward D Kim Ryan C Owen Gregory S White Osama O Elkelany Cyrus D Rahnema | 2015 | Asian Journal of Andrology2015，17，1： | 3 |
| 5 | Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours显示文摘 | Owens DM Hulsken J | 2002 | Development2002，129，1： | 1 |
| 6 | A simple expression for the shapley value in a special case显示文摘 | LITYLTCHILD S C OWEN G | 1973 | Management Science1973，20，： | 1 |
| 7 | Solid phase microextraction(SPME)combined with gas-chromatography and olfactometry-massspectrometry for characterization ofcheesearoma compounds显示文摘 | FRANK D C OWEN C M PATTERSON J | 2004 | Lebensm-Wiss Technol2004，37，： | 1 |
| 8 | CBF10rthologs in Sour Cherry and Strawberry and The Heterologous Expression of CBFI in Strawberry显示文摘 | OWENS C L THOMASHOW M F HANCOCK J F | 2002 | J Am Soci Hort Sci2002，127，4： | 1 |
| 9 | Feature-based reverse engineering of mechanical parts显示文摘 | Thompson W B Owen J C Stark S R | 1999 | IEEE Transactions on Robotics and Automation1999，15，1： | 1 |
| 10 | Insulin-like growth Factor- Ⅰ (IGF- Ⅰ ) and especially IGF- Ⅰ variants are anabolic in dexamethasone-treated rat显示文摘 | Tomas F M Knowles S E Owens P C | 1992 | Biochem J1992，282，： | 1 |
| 11 | Feature detection from local energy显示文摘 | MORRONE M C OWENS R | | 0，，05： | 1 |
| 12 | The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys 显示文摘 | Stremlau M Owens C M Perron M J | 2004 | Nature2004，427，6977： | 1 |
| 13 | Feature detection from local energy 显示文摘 | Morrone M C Owens R A | 1987 | Pattern Recognition Letters (S0167-8655)1987，6，5： | 1 |
| 14 | Mapping the sigma70 subunit contact sites on Escherichia coli RNA polymerase with a sigma70-conjugated chemical protease显示文摘 | Owens J T Miyake R Meares C F | 1998 | Proc Natl Aced Sci USA1998，95，： | 1 |
| 15 | Temporal variability of denitrification in estuarine sediments显示文摘 | LAW C S REES A P OWENS N J P | 1991 | Estuarine Coastal and Shelf Science1991，33，1： | 1 |
| 16 | Estimation of the surface free energy of polymers显示文摘 | OWENS D K WENDT R C | 1969 | Journal of Applied Polymer Science1969，13，8： | 1 |
| 17 | Enhancement of Freezing Tolerance of Strawberry by Heterologous Expression of CBFI显示文摘 | OWENS C L LEZZONI A F HANCOCK J F | 2003 | ActaHort2003，，626： | 1 |
| 18 | Integrating glycaemic vari- ability in the glycaemic disorders of type 2 diabetes: a move to- wards a unified glucose tetrad concept 显示文摘 | Monnier L Colette C Owens DR | 2009 | Diabetes Metab Res Rev2009，25，5： | 1 |
| 19 | Efficacy of anescherichia coli phytase in broilers fed adequate or reducedphosphorus diets and its effect on carcass characteristics显示文摘 | Pillai P B Owens C M Emmert J L | 2006 | Poult Sci2006，85，10： | 1 |
| 20 | Characterization of the resin transfer moulding process显示文摘 | KENDALL K N RUDD C D OWEN M J | 1992 | Composites Manufacturing1992，3，4： | 1 |
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