|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pegylated interferon-alpha plus taurine in treatment of rat liver fibrosis显示文摘AIM: To investigate the antif ibrotic effects of peginterferon- alpha 2b and taurine on oxidative stress markers and hepatocellular apoptosis. METHODS: Sixty rats with CCl4-induced liver fibrosis were divided into 4 groups (n = 15). Group 1 was left for spontaneous recovery (SR). Groups 2-4 received peginterferon-alpha 2b, taurine, and their combination, respectively, for four weeks. Histological f ibrosis scores, histomorphometric analysis, tissue hydroxyproline, tissue MDA, GPx and SOD activities were determined. Activated stellate cells and hepatocellular apoptosis were also evaluated. RESULTS: The degree of f ibrosis decreased in all treatment groups compared to spontaneous recovery group. Taurine alone and in combination with peginterferon-alpha 2b reduced oxidative stress markers, but peginterferon-alpha 2b alone did not. Apoptotic hepatocytes and activated stellate cells were higher in groups 2-4 than in group 1. Combined taurine and peginterferon-alpha 2b further reduced fibrosis and increased activated stellate cell apoptosis, but could not improve oxidative stress more than taurine alone.CONCLUSION: Peginterferon-alpha 2b exerts anti- f ibrotic effects on rat liver fibrosis. It seems ineffective against oxidative stress in vivo. Peginterferon-alpha 2b in combination with taurine seems to be an antif ibrotic strategy. | Ilker Tasci Mehmet Refik Mas Sevil Atalay Vural Salih Deveci Bilgin Comert Gunay Alcigir Nuket Mas Cemal Akay Mithat Bozdayi Cihan Yurdaydin Hakan Bozkaya Ozden Uzunalimoglu Ahmet Turan Isik Harun M Said | 2007 | World Journal of Gastroenterology2007，13，23： | 7 |
| 2 | The ORF3 protein of hepatitis E virus is a phosphoprotein that associates with the cy- toskeleton 显示文摘 | Zafrullah M Ozdener MH Panda SK | 1997 | J Virol1997，71，12： | 1 |
| 3 | Adaptive multichannel decision feedback equalization for volterra type nonlinear communication channels 显示文摘 | Ozden M T Kayran A H | 2008 | AEU-International Journal of Electronics and Communications2008，62，6： | 1 |
| 4 | Long-term outcomes of thymosin-alphal and interferon alpha-2b combination therapy in patients with hepatitis B e antigen (HBeAg)negative chronic hepatitis B显示文摘 | SARUE M OZDEN N TURKEL N | 2003 | Journal of Pharmaceutical Sciences2003，92，7： | 1 |
| 5 | Effect of different dose gamma radiation and refrigeration on the chemical and sensory properties and microbiological status of aquacultured sea bass ( Dicentrarchus labrax ) 显示文摘 | Ozden O Inugur M Nuray E | 2007 | Radiation Physics and Chemistry2007，76，： | 1 |
| 6 | Biomechanical compar-ison of plating techniques for fractures of the mandibularcondyle 显示文摘 | Alkan A Metin M Ozden B | 2007 | Br J Oral Maxillofac Surg2007，45，2： | 1 |
| 7 | Use of complementary and alternative medicine in cancer patients:a European survey显示文摘 | Molassiotis A Fernadez-Ortega P Pud D Ozden G Scott JA Panteli V Margulies A Browall M Magri M Selvekerova S Madsen E Milovics L Bruyns I Gudmundsdottir G Hummerston S Ahmad AM Platin N Keamey N Patiraki E | | 0，，04： | 1 |
| 8 | Human muscle satellite cells as targets of Chikungunya virus infection 显示文摘 | Ozden S Huerre M Riviere JP | 2007 | PLoS ONE2007，2，6： | 1 |
| 9 | Somatostatin and propranolol to treat small-for-size syndrome that occurred despite splenic artery ligation显示文摘 | Ozden I Kara M Pinarbasi B | 2007 | Exp Clin Transplant2007，5，2： | 1 |
| 10 | Maloodialdehyde,glutathione,glutathione peroxidase and homocysteine level is type 2 diabetic patients with and without micyoalbuminuria显示文摘 | Ozdemir G Ozden M Maral H | 2005 | Ann Clin Biochem2005，42，2： | 1 |
| 11 | The ORF3 protein of hepatitis E virus is a phosphoprotein that associates with the cytoskeleton显示文摘 | Zafrullah M Ozdener MH Panda SK | 1997 | J Virol1997，71，： | 1 |
| 12 | Erythrocyte glutathione peroxidase activity, plasma malondialdehyde and erythrocyte glutathione levels in hemodialysis and CAPD patients 显示文摘 | Ozden M Maral H Akaydin D | 2002 | Clin Biochem2002，35，4： | 1 |
| 13 | Serum cytokine levels in patients with acute brucellosis and their relation to the traditional inflammatory markers显示文摘 | Demirdag K Ozden M Kalkan A | 2003 | FEMS Immunol Med Microbio2003，39，： | 1 |
| 14 | Thymosin in the treatment of HBeAg-negative chronic hepatitis B 显示文摘 | SARUC M OZDEN N YUCEYAR H | 2003 | Med Sci Monit2003，9，8： | 1 |
| 15 | Diasporas显示文摘 | Beine M Docquier F Ozden C | 2011 | Journal of Development Economics2011，95，1： | 1 |
| 16 | Migrant networks and foreign direct investment显示文摘 | Javorcik B S Ozden C Spatareanu M | 2011 | Journal of De- velopment Economics2011，94，2： | 1 |
| 17 | The ORF3 protein of hepatitis E virus is a phosphoprotein that associates with the cytoskeleton显示文摘 | Zafrullah M Ozdener M H Panda S K | 1997 | J Virol1997，71，12： | 1 |
| 18 | Long-term outcomes of thymosin-alpha 1 and interferon alpha-2b combination therapy in patients with hepatitis B e antigen (HBeAg) negative chronic hepatitis B显示文摘 | Saruc M Ozden N Turkel N | 2003 | J Pharm Sci2003，92，： | 1 |
| 19 | Computational analysis of foul- ing by low energy surfaces 显示文摘 | OZDEN H O PURI V M | 2010 | Journal of Food Engineer- ing2010，99，： | 1 |
| 20 | Incidence of bacteraemia after urodynamic study显示文摘 | Onur R ozden M Orhan I | 2004 | J of Hospital Infection2004，57，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员