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| 1 | Risk factors for bleeding after endoscopic submucosal dissection for gastric lesions显示文摘AIM:To assess risk factors for bleeding after gastric endoscopic submucosal dissection(ESD) and to develop preventive measures.METHODS:This retrospective study was performed in a tertiary referral center.A total of 328 patients underwent ESD for 398 gastric neoplasms between July 2007 and June 2009.The main outcome was association between post-ESD bleeding and the following:age;sex;comorbidities;daily use of medicine potentially related to gastric injury/bleeding;location,size,and histological depth of lesions;ulceration;experience of operator coagulating the ulcer floor,and duration of operation.We also determined the relationship between the location of post-ESD bleeding and risk factors for hemorrhage.RESULTS:Univariate analysis revealed significant risk factors:tumor location [odds ratio(OR),2.86;95% CI:1.21-6.79,P=0.024],coagulator experience(OR,4.29;95% CI:1.43-12.86,P=0.009),and medicine potentially related to gastric injury/bleeding(OR,2.80;95% CI:1.14-6.90,P=0.039).Multivariate logistic regression analysis confirmed significant,independent risk factors:tumor in lower third of stomach(OR,2.47;95% CI:1.02-5.96,P=0.044),beginner coagulator(OR,3.93;95% CI:1.29-11.9,P=0.016),and medicine(OR,2.76;95% CI:1.09-6.98,P=0.032).We classif ied cases of post-ESD bleeding into two groups(bleeding at the ulcer margin vs bleeding at the center) and found that bleeding at the margin occurred more frequently with beginner coagulators compared with experts(OR,16.00;95% CI:1.22-210.59,P=0.040).CONCLUSION:Beginner coagulators,tumor in the antrum,and medicines were significant risk factors for post-ESD bleeding.Bleeding at the ulcer margin frequently occurred with beginner operators. | Yosuke Tsuji Ken Ohata Takafumi Ito Hideyuki Chiba Tomohiko Ohya Toshiaki Gunji Nobuyuki Matsuhashi | 2010 | World Journal of Gastroenterology2010，16，23： | 60 |
| 2 | Simplified criteria for diagnosing superficial esophageal squamous neoplasms using Narrow Band Imaging magnifying endoscopy显示文摘AIM To simplify the diagnostic criteria for superficial esophageal squamous cell carcinoma(SESCC) on Narrow Band Imaging combined with magnifying endoscopy(NBI-ME).METHODS This study was based on the post-hoc analysis of a randomized controlled trial. We performed NBI-ME for 147 patients with present or a history of squamous cell carcinoma in the head and neck, or esophagus between January 2009 and June 2011. Two expert endoscopistsdetected 89 lesions that were suspicious for SESCC lesions, which had been prospectively evaluated for the following 6 NBI-ME findings in real time: 'intervascular background coloration'; 'proliferation of intrapapillary capillary loops(IPCL)'; and 'dilation', 'tortuosity', 'change in caliber', and 'various shapes(VS)' of IPCLs(i.e., Inoue's tetrad criteria). The histologic examination of specimens was defined as the gold standard for diagnosis. A stepwise logistic regression analysis was used to identify candidates for the simplified criteria from among the 6 NBI-ME findings for diagnosing SESCCs. We evaluated diagnostic performance of the simplified criteria compared with that of Inoue's criteria.RESULTS Fifty-four lesions(65%) were histologically diagnosed as SESCCs and the others as low-grade intraepithelial neoplasia or inflammation. In the univariate analysis, proliferation, tortuosity, change in caliber, and VS were significantly associated with SESCC(P < 0.01). The combination of VS and proliferation was statistically extracted from the 6 NBI-ME findings by using the stepwise logistic regression model. We defined the combination of VS and proliferation as simplified dyad criteria for SESCC. The areas under the curve of the simplified dyad criteria and Inoue's tetrad criteria were 0.70 and 0.73, respectively. No significant difference was shown between them. The sensitivity, specificity, and accuracy of diagnosis for SESCC were 77.8%, 57.1%, 69.7% and 51.9%, 80.0%, 62.9% for the simplified dyad criteria and Inoue's tetrad criteria, respectively.CONCLUSION The combination of proliferation and VS may serve as simplified criteria for the diagnosis of SESCC using NBIME. | Akira Dobashi Kenichi Goda Noboru Yoshimura Tomohiko R Ohya Masayuki Kato Kazuki Sumiyama Masato Matsushima Shinichi Hirooka Masahiro Ikegami Hisao Tajiri | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 3 | 择期脊柱手术术后输血相关感染并发症的风险显示文摘异体输血在脊柱手术中应用广泛,但存在许多潜在风险,如手术切口感染(surgical site infection,SSI)、免疫系统功能下降、费用增加等.尽管其负面影响已被逐渐认知,但对于脊柱手术患者所面临的与输血相关的风险,人们却知之甚少。 | Kato S Chikuda H Ohya J 胡玮 杨进城 | 2016 | 中国骨科临床与基础研究杂志2016，8，2： | 10 |
| 4 | Short-and long-term outcomes of endoscopically treated superficial non-ampullary duodenal epithelial tumors显示文摘BACKGROUND It is widely recognized that endoscopic resection(ER) of superficial nonampullary duodenal epithelial tumors(SNADETs) is technically challenging and may carry high risks of intraoperative and delayed bleeding and perforation.These adverse events could be more critical than those occurring in other levels of the gastrointestinal tract. Because of the low prevalence of the disease and the high risks of severe adverse events, the curability including short-and long-term outcomes have not been standardized yet.AIM To investigate the curability including short-and long-term outcomes of ER for SNADETs in a large case series.METHODS This retrospective study included cases that underwent ER for SNADETs at our university hospital between March 2004 and July 2017. Short-term outcomes of ER were measured based on en bloc and R0 resection rates as well as adverse events. Long-term outcomes included local recurrence detected on endoscopic surveillance and disease-specific mortality in patients followed up for ≥ 12 mo after ER.RESULTS In the study, 131 patients with 147 SNADETs were analyzed. The 147 ERs consisted of 136 endoscopic mucosal resections(EMRs)(93%) and 11 endoscopic submucosal dissections(ESDs)(7%). The median tumor diameter was 10 mm.The pathology diagnosis was adenocarcinoma(56/147, 38%), high-grade intraepithelial neoplasia(44/147, 30%), or low-grade intraepithelial neoplasia(47/147, 32%). The R0 resection rate was 68%(93/136) in the EMR group and73%(8/11) in the ESD group, respectively. Cap-assisted EMR(known as EMR-C)showed a higher rate of R0 resection compared to the conventional method of EMR using a snare(78% vs 62%, P = 0.06). No adverse event was observed in the EMR group, whereas delayed bleeding, intraoperative perforation, and delayed perforation in 3, 3, and 5 patients occurred in the ESD group, respectively. One patient with perforation required emergency surgery. In the 43 mo median follow-up period, local recurrence was found in four EMR cases and all cases were treated endoscopically. No patient died due to tumor recurrence.CONCLUSION Our findings suggest that ER provides good long-term outcomes in the patients with SNADETs. EMR is likely to become the safe and reliable treatment for small SNADETs. | Yuko Hara Kenichi Goda Akira Dobashi Tomohiko Richard Ohya Masayuki Kato Kazuki Sumiyama Takehiro Mitsuishi Shinichi Hirooka Masahiro Ikegami Hisao Tajiri | 2019 | World Journal of Gastroenterology2019，25，6： | 9 |
| 5 | A prospective randomized trial of lafutidine vs rabeprazole on post-ESD gastric ulcers显示文摘AIM:To compare the effects of rabeprazole and lafutidine on post-endoscopic submucosal dissection(ESD) gastric ulcers.METHODS:Patients with gastric tumors indicated for ESD were prospectively studied.After ESD,all patients were treated with intravenous omeprazole for the first 3 d.Patients were then randomly assigned to oral lafutidine or rabeprazole.Ulcer size,ulcer size reduction rate,and ulcer stage were evaluated 4 wk later.Occurrence of complication was monitored throughout the 4-wk period.RESULTS:Sixty five patients were enrolled in the study,and 60 patients were subjected to the final analysis.In the lafutidine group(30 lesions in 29 patients),initial and 4-wk post-ESD ulcer sizes were 33.3 ± 9.2 and 10.5 ± 4.8 mm,respectively.In the rabeprazole group(34 lesions in 31 patients),the values were 34.7 ± 11.3 and 11.8 ± 6.7 mm,respectively.Ulcer size reduction rates in lafutidine and rabeprazole groups were 32.3% and 33.5%,respectively(P=0.974).Ulcer stage 4 wk post-ESD did not differ significantly between the two groups(P=0.868).Two cases in the rabeprazole group and no cases in the lafutidine group developed ulcer bleeding during the oral dose period,although the difference of bleeding rate between the two groups was not statistically significant(P=0.157).CONCLUSION:Lafutidine and rabeprazole have equivalent therapeutic effects on post-ESD gastric ulcers. | Tomohiko Richard Ohya Hiroki Endo Kei Kawagoe Tatsuro Yanagawa Katsuhiro Hanawa Ken Ohata Masako Asayama Kantaro Hisatomi Takuma Teratani Toshiaki Gunji Hajime Sato Nobuyuki Matsuhashi | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，1： | 7 |
| 6 | Overexpression of S-adenosylmethionine decarboxylase(SAMDC)in Xeno-pus embryos activates maternal program of apoptosis as a 'fail-safe'mechanism of early embryogenesis显示文摘In Xenopus, injection of S-adenosylmethionine decarboxylase (SAMDC) mRNA into fertilized eggs or 2-cell stage embryos induces massive cell dissociation and embryo-lysis at the early gastrula stage due toactivation of the maternal program of apoptosis. We injected SAMDC mRNA into only one of the animalside blastomeres of embryos at different stages of cleavage, and examined the timing of the onset of theapoptotic reaction. In the injection at 4-and 8-cell stages, a considerable number of embryos developed intotadpoles and in the injection at 16-and 32-cell stages, all the embryos became tadpoles, although tadpolesobtained were sometimes abnormal. However, using GFP as a lineage tracer, we found that descendant cellsof the blastomere injected with SAMDC mRNA at 8-to 32-cell stages are confined within the blastocoel atthe early gastrula stage and undergo apoptotic cell death within the blastocoel, in spite of the continued development of the injected embryos. These results indicate that cells overexpressed with SAMDC undergo apoptotic cell death consistently at the early gastrula stage, irrespective of the timing of the mRNA injection.We assume that apoptosis is executed in Xenopus early gastrulae as a 'fall-safe' mechanism to eliminate physiologically-severely damaged cells to save the rest of the embryo. | MASATAKEKAI CHIKARAKAITO HIROSHIFUKAMACHI TAKAYASUHIGO EIJI TAKAYAMA HIROSHI HARA YOSHIKAZU OHYA KAZUEI IGARASHI KOICHIRO SHIOKAWA | 2003 | Cell Research2003，13，3： | 4 |
| 7 | PIV Measurements of Flows around the Wind Turbines with a Flanged-Diffuser Shroud显示文摘当高效之一由 Ohya 等弯屈汽轮机,有称为“风透镜汽轮机”的凸缘弥漫的笼罩这样的风汽轮机被开发。以便调查流动特征和流动加速,纸论述流动速度大小一长类型并且紧缩类型的风有由粒子图象 velocimetry 的凸缘弥漫的笼罩的汽轮机。在长类型风汽轮机的情况中,内部流动的速度向量回答为汽轮机片旋转和旋转的没有片更弥漫在雷纳兹数字被介绍, 0.9 × 1 05。而且,流动回答在之间有或没有旋转被比较。通过 PIV 测量结果,一个人能认识到旋转的汽轮机片是影响在内部墙附近压制骚乱和流动分离更弥漫。时间平均速度向量在即时速度数据的一般水准上被做。在下游的区域有二个大旋涡更弥漫。在凸缘后面的一个旋涡是行动吸在风中到更弥漫并且提起入口流动速度。另一个大旋涡出现在 downstream。它可能作为主要流动的阻塞旋涡是行为。大阻塞旋涡不在即时速度向量是清楚的,然而,它在时间一般水准流动地里清楚地存在。在有紧缩类型的凸缘弥漫的笼罩的风汽轮机附近的流动地也被调查。在紧缩类型的汽轮机的凸缘后面的流动模式与长类型的一样。它意味着流动加速的效果被不稳定的旋涡在凸缘后面引起。有南方的时间一般水准的 CFD 和 PIV 结果的比较优化在以后紧缩类型更弥漫也被介绍。 | Kazuhiko Toshimitsu Koutarou Nishikawa Wataru Haruki Shinichi Oono Manabu Takao Yuji Ohya | 2008 | Journal of Thermal Science2008，17，4： | 2 |
| 8 | Grb10/GrbIR as an in vivo substrate of Tec tyrosine kinase显示文摘 | MANO H OHYA K MIYAZATO A | 1998 | Genes Cells1998，3，7： | 1 |
| 9 | Molecular and functional characterization of ERG,KCNQ,and KCNE subtypes in rat stomach smooth muscle显示文摘 | Ohya S Asakura K Muraki K | 2002 | Am J Physiol Gastrointest Liver Physiol2002，282，2： | 1 |
| 10 | Recovering copper from electric cable wastes using a particle shape separation technique显示文摘 | Koyanaka S Ohya H Endoh S et aI | 1997 | Advanced Powder Technology1997，8，2： | 1 |
| 11 | Home environment and suspected atopic eczema in Japanese infants:The osaka maternal and child health study 显示文摘 | Miyake Y Ohya Y Tanaka K | 2007 | Pediatr Allergy Immunol2007，18，5： | 1 |
| 12 | Mycoplasma pneurnoniae isolated from patients with respiratory infection in Kanagawa Prefecture in 1976 2006: emergence of macrolide resistant strains显示文摘 | Okazaki N Ohya H Sasaki T | 2007 | Jpn J Infect Dis2007，60，5： | 1 |
| 13 | Early detection of salt stress damage by biophotons in red bean seedling显示文摘 | OHYA T KURASHIGE H OKABE H | 2000 | Japanese Journal of Applied Physics2000，39，6： | 1 |
| 14 | Microstructures relevant to brittle fracture initiation at the heat-affected zone of weldment of a low carbon steel显示文摘 | Ohya K Kim J Yokoyama K | 1996 | Metallurgical and Materials Transactions A1996，27，9： | 1 |
| 15 | Usefulness and limitation of DiBAC4(3), a voltage sensitive fluoresent dye for the measurement of membrane potentials regulated by recombinant large conductance Ca2+ actived K+ channel in HEK293 cells 显示文摘 | Yamda A Gaja N Ohya S | 2001 | J Pharmacol2001，86，3： | 1 |
| 16 | Hyperinsulinemia and left ventricular geometryin a work-site population in Japan显示文摘 | Ohya Y Abe I Fujii K | 1996 | Hypertension1996，27，： | 1 |
| 17 | Telomerase activity in lung cancercells obtained from bronchial washings显示文摘 | Yahata N Ohyshiki K Ohya shiki JH | 1998 | J Natl Cancer Inst1998，90，： | 1 |
| 18 | Biodegradation and Immunological Enhancement Activity of Dicarboxy-Glucomarman' Having Recognizable Branched Saccharide Residues显示文摘 | Ohya Y Ihara K Murata J | 1995 | Intelligent Materials and Systems1995，，： | 1 |
| 19 | Improvements in the measurement of stool decay-accelerating factorin the detection of colorector cancer 显示文摘 | Ohya S Mizuno M Kawada M | 2002 | Acta Med Okayama2002，56，4： | 1 |
| 20 | Effects of blood pressurelevels on case fatality after acute stroke显示文摘 | Okumura K Ohya Y Maehara A | 2005 | J Hypertens2005，23，6： | 1 |
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