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| 1 | Prostate-associated gene 4 (PAGE4), an intrinsically disordered cancer/testis antigen, is a novel therapeutic target for prostate cancer显示文摘联系前列腺的基因(PAGE4 ) 4 是是的显著地前列腺特定的癌症 / 睾丸抗原高度,在人的胎儿的前列腺和它的 diseased 的 upregulated 说然而并非在成年的正常的腺。PAGE4 是作为压力反应蛋白质工作压制反应的氧种类以及阻止 DNA 损坏的内在地混乱的蛋白质(IDP ) 。另外, PAGE4 也是加强的一个 transcriptional 管理者由 oncogene c-Jun.c6 月的 transactivation 与 Fos 家庭的成员一起由 heterodimerizing 形成 AP-1 建筑群并且在前列腺的发展和病理起一个重要作用,强调 PAGE4/c-Jun 相互作用的重要性。HIPK1,另外压力反应小径的一个部件,在为它的 transcriptional 活动批评的 T51 的 phosphorylates PAGE4。Phosphorylation 导致 conformational 并且在导致新细胞的功能的 PAGE4 整体的动态切换。最后,生物信息学证据建议 PAGE4 mRNA 能或者被拼接导致与潜伏的功能提到 conformational 整体的一个范围的可能性的多肽的四潜在的 isoforms。一起考虑了,数据建议 PAGE4 可以代表在应力和前列腺癌症(PCa ) 之间的第一个分子的连接。因此, pharmacologically 指向 PAGE4 可以是为与 PCa 对待并且设法病人的一个新奇机会,特别有低风险的疾病的病人。 | Prakash Kulkarni A Keith Dunker Keith Weninge John Orban | 2016 | Asian Journal of Andrology2016，18，5： | 3 |
| 2 | 微卫星跨物种交叉PCR扩增的一个新问题:扩增非同源产物(英文)显示文摘微卫星已被广泛应用于群体遗传学、生态学和进化生物学研究。然而,一些物种微卫星尚未克隆。为了节省时间和经费,研究人员往往使用一个物种已发表的微卫星引物扩增其近缘物种的微卫星。该研究对属于3个不同科(Clariidae、Heteropneustidae和Pimelodidae)的7个鲶鱼物种的微卫星跨物种PCR扩增产物进行了序列分析,研究发现扩增非同源(non-orthologous)产物是微卫星跨物种PCR扩增的一个新问题。该研究共采用4对胡子鲶微卫星座位引物对7个鲶鱼物种进行了跨物种PCR扩增。对获得的204个PCR产物的序列分析结果表明,两对微卫星座位引物扩增了所有7个物种的同源特异产物。而其他两个座位的引物扩增了特异但非同源的多态产物,对近缘物种的扩增也获得类似结果。另外,除胡子鲶等位基因大小异源同型(size homoplasy)的特征不明显外,其他物种在3个微卫星座位都具有这一非常明显的特征。这些数据表明,微卫星跨物种间交叉扩增能产生非同源产物;等位基因大小异源同型与微卫星座位本身有关,而与物种间的亲缘关系无明显的相关性。微卫星跨物种扩增产生的非同源产物和等位基因大小异源同型将使系统发育、群体遗传学和进化研究明显复杂化。因此,在应用微卫星跨物种交叉扩增数据以前,最好对跨物种交叉扩增产物进行测序验证。 | 岳根华 Balazs Kovacs Laszlo Orban | 2010 | Zoological Research2010，31，2： | 3 |
| 3 | High-fructose diet preserves β-cell mass and prevents diabetes in nonobese diabetic mice: A potential role for increased insulin receptor substrate-2 expression 显示文摘 | Orban T Landaker E Ruan Z | 2001 | Metabolism2001，50，11： | 1 |
| 4 | Human brain activity related to speed discrimination tasks显示文摘 | Orban GA Dupont P De Bruyn B | 1998 | Exp Brain Res1998，122，1： | 1 |
| 5 | The complete mitochondrial genome of a basal teleost, the Asian arowana(Scleropages formosus, Osteoglossidae)显示文摘 | Yue G H Liew W C Orban L | 2006 | BMC Genomics2006，7，： | 1 |
| 6 | Dynamic chan- ges of left ventricular performance and left atrial volume in- duced by the mueller maneuver in healthy young adults and implications for obstructive sleep apnea, atrial fibrillation, and heart failure显示文摘 | Orban M Bruce C J Pressman GS | 2008 | Am J Cardiol2008，102，11： | 1 |
| 7 | Aber-rant positioning of trophoblast and lymphocytes in the feto-maternal interface with pre-eclampsia显示文摘 | STALLMACH T HEBISCH G ORBAN P | 1999 | Virchows Arch1999，434，3： | 1 |
| 8 | Uncompensated Care Provided by Emergency Physicians in Florida Emergency Departments 显示文摘 | Barbara Iangland - Orban Etienne Pracht Seena Salyani | 2005 | Health Care Management Review2005，0，： | 1 |
| 9 | Influence of enzymatic hydrolysis on struc-ture and emulsifying properties of sardine(Sardina pilchardus)proteinhydrolysate显示文摘 | QUAGLIA G B ORBAN E | 1990 | Journal of Food Science1990，55，15： | 1 |
| 10 | National registry of patients with juvenile idiopathic inflammatory myopa- thies in Hungary--clinical characteristics and disease course of 44 patients with juvenile dermatomyositis 显示文摘 | Constantin T Ponyi A Orban I | 2006 | Autoimmunity2006，39，3： | 1 |
| 11 | Women business owners in France: the issue of financing discrimination显示文摘 | ORBAN M | 2001 | Journal of small Business Management2001，，39： | 1 |
| 12 | Kinetic analysis of immunointeraction with covalently immobilized fatty acid-binding protein using a grating coupler显示文摘 | Orban M Kaaterkamp A Renneberg R | | 0，，： | 1 |
| 13 | Dimensions and relations of the dentogingivalJunction in humans显示文摘 | Gargiulo MF Wentz FM Orban B | 1961 | J Periodontol1961，32，3： | 1 |
| 14 | Hierarchical strategy for treating elevated intraeranial pressure in severe traumatic brain injury 显示文摘 | Orban JC Iehai C | 2007 | Ann Fr Anesth Reanim2007，26，5： | 1 |
| 15 | Sequence alterations can mask eachother's presence during screening with SSCP or heteroduplex analysis: BRCA genes as examples显示文摘 | Orban TI Csokay B Olah E | 2000 | Biotechniques2000，29，1： | 1 |
| 16 | Enzymic solubilisation of proteins of shardine (Shardine pilchardus) by commercial proteases显示文摘 | Quaglia G B Orban E | 1987 | J Sci Food Agri1987，38，： | 1 |
| 17 | Under - diagnosis of sleep apnea in patients after acute myocardial infarction 显示文摘 | Konecny T Kuniyoshi FH Orban M | 2010 | J Am Cardiol2010，56，9： | 1 |
| 18 | An experimental investigation of properties of polyethylene reinforced with Al powders显示文摘Mechanical and physical properties, such as tensile strength, elongation at break, modulus of elasticity, Shore D hardness, melt flow rate (MFR), and electrical and thermal conductivities of composites with high density polyethylene matrix reinforced with Al powders were investigated experimentally. Measurements of the mechanical and physical properties were performed up to a reinforcing component concentration of 30% volume Al powder and compared with mathematical models from the literature. The obtained results have shown that experimental data were in good agreement with theoretical data. The ultimate tensile strength (UTS) and elongation at break decreased with increasing Al powder content, which was attributed to the intro-duction of discontinuities in the polymer structure, and modulus of elasticity increased with increasing Al content. The composite preparation conditions allowed the formation of a random distribution of metallic particles in the polymer matrix volume for system high density polyethylene-Al (HDPE-Al). There was a cluster formation of Al particles at higher Al contents in the polymer matrix. Electrical and thermal conductivity values of HDPE-Al composites were higher than pure HDPE values. | Victoria CHIFOR Zafer TEKINER Mehmet TURKER Radu ORBAN | 2011 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2011，12，8： | 1 |
| 19 | Dimension and relations of the dentogingival junction in humans显示文摘 | Gargiulo AW Wentz FM Orban B | 1961 | J Periodontol1961，32，： | 1 |
| 20 | Do programs designed to train working memory, other executive functions, and attention benefit children with ADHD? A meta-analytic review of cognitive,academic, and behavioral outcomes 显示文摘 | Rapport MD Orban SA Kofler M J | 2013 | Clin Psychol Rev2013，33，8： | 1 |
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