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| 1 | Prophylaxis with ketotifen in rats with portal hypertension:involvement of mast cell and eicosanoids显示文摘BACKGROUND:Since we have previously shown an increase of mast cells in the small bowel and in the mesenteric lymph nodes in the rats with prehepatic portal hypertension,it can be hypothesized that this essential inflammatory cell would be involved in the pathogeny of the splanchnic changes related to portal hypertension. METHODS:To verify this hypothesis,we first studied mast cell infiltration in the ileum and in the mesenteric lymph nodes in sham-operated male Wistar rats(n=12) and in short-term prehepatic portal hypertensive rats (n=12),and the serum levels of rat mast cell protease Ⅱ(RMCP-Ⅱ)by ELISA.In a second set of experiments ketotifen,a mast cell stabilizer drug,was administered to sham-operated(n=10)and portal hypertensive(n=12) rats 24 hours before the intervention and prostanoids (PGE2,PGI2,TXB2)and leukotrienes(LTC4,LTB4)were assayed by RIA,mast cell infiltration in the ileum and in the mesenteric lymph nodes and the serum levels of RMCP-Ⅱwere also studied,to show its effectiveness to prevent the mesenteric alterations produced by the inflammatory mediators released by the mast cell. RESULTS:Forty-eight hours after the intervention RMCP-Ⅱ (P<0.05),PGE2(P<0.001)and LTC4 serum levels decreased and mast cell number and RMCP-Ⅱlevels increased in mesenteric lymph nodes in portal hypertensive rats.Prophylactic administration of ketotifen reduced portal pressure(P<0.001),serum levels of PGE2(P<0.001)and RMCP-Ⅱ(P<0.001)in mesenteric lymph nodes. CONCLUSIONS:In acute portal hypertension in the rat,the mast cell translocation from intestinal mucosa to mesenteric lymph nodes,where they are activated and degranulates,would represent a defence mechanism to avoid the activation of an acute and massive inflammatory response in this location.Prophylactic administration of ketotifen is able to reduce the splanchnic inflammatory changes related to acute portal hypertension in the rat. | Fernando Sánchez-Patán Raquel Anchuelo Elena Vara Cruz García Yolanoa Saavedra Patri Vergara Carmen Cuellar Marta Rodero Maria-Angeles Aller Jaime Arias | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 2 |
| 2 | Hepatic lipid metabolism changes in short-and long-term prehepatic portal hypertensive rats显示文摘AIM: To verify the impairment of the hepatic lipid metabolism in prehepatic portal hypertension. METHODS: The concentrations of free fatty acids, diacylglycerol, triglycerides, and phospholipids were assayed by using D-[U-14C] glucose incorporation in the different lipid fractions and thin-layer chromatography and cholesterol was measured by spectrophotometry, in liver samples of Wistar rats with partial portal vein ligation at short- (1 mo) and long-term (1 year) (i.e. portal hypertensive rats) and the control rats. RESULTS: In the portal hypertensive rats, liver phospholipid synthesis significantly decreased (7.42 ± 0.50 vs 4.70 ± 0.44 nCi/g protein; P < 0.01) and was associated with an increased synthesis of free fatty acids (2.08 ± 0.14 vs 3.36 ± 0.33 nCi/g protein; P < 0.05), diacylglycerol (1.93 ± 0.2 vs 2.26 ± 0.28 nCi/g protein), triglycerides (2.40 ± 0.30 vs 4.49 ± 0.15 nCi/g protein) and cholesterol (24.28 ± 2.12 vs 57.66 ± 3.26 mg/g protein; P < 0.01). CONCLUSION: Prehepatic portal hypertension in rats impairs the liver lipid metabolism. This impairment consists in an increase in lipid deposits (triglycerides,diacylglycerol and cholesterol) in the liver, accompanied by a decrease in phospholipid synthesis. | Maria-Angeles Aller Elena Vara Cruz García Maria-Paz Nava Alejandra Angulo Fernando Sánchez-Patán Ana Calderón Patri Vergara Jaime Arias | 2006 | World Journal of Gastroenterology2006，12，42： | 2 |
| 3 | Subclinical 'electrical status epilepticus' induced by sleep in children显示文摘 | Patry G Lyagoubi S Tassinari CA | 1971 | Arch Neurol1971，24，3： | 1 |
| 4 | Profile design considerations for minimizing base transit time in SiGe HBT's 显示文摘 | PATRI V S KUMAR M J | 1998 | IEEE Trans Elec Dev1998，45，8： | 1 |
| 5 | A cost - effective screening test for detecting AZF Microdeletions on the human Y chromosome 显示文摘 | Patri P C Pleria D H Glina S | 2002 | Genet Test2002，6，3： | 1 |
| 6 | Profile design considerations for minimizing base transit time in SiGe HBT's 显示文摘 | Patri V S Kumar M J | 1998 | IEEE Trans ED1998，45，8： | 1 |
| 7 | high-speed SiGe HBTs:Novel Ge-profile design forModelling and analysis 显示文摘 | Patri V S Kumar M J | 1999 | IEE Proc-Circuits Devices Syst1999，146，5： | 1 |
| 8 | A Novel Polyurethane Adhesive Based on Hydroxyl-Terminated Polybatadiene显示文摘 | PATRI M RATH S K SURYAVANSI U G | 2006 | Journal of Applied Polymer Science2006，99，： | 1 |
| 9 | Design,Synthesis,and in Vitro Transfection Biology of Novel Tocopherol Based Monocationic Lipids:A Structure-activity Investigation显示文摘 | KEDIKA B PATRI S V | 2011 | J of Medicine Chem2011，54，： | 1 |
| 10 | A transaction cost model of IT outsourcing 显示文摘 | AUBERT B A RIVERD S PATRY M | 2004 | Information & Management2004，41，7： | 1 |
| 11 | Subclinical electrical status epilepticus induced by sleep in children 显示文摘 | PATRY G LYAGOUBI S TASSINARI CA | 1971 | Arch Neurol1971，24，4： | 1 |
| 12 | The heart rate-lowering agent ivabradine inhibits the pacemaker current If in human atrial myocytes显示文摘 | Chemaly A Christopne M Patri S | 2007 | Cardiovasc Electrophysiol2007，18，11： | 1 |
| 13 | Subclinical electrical status epilepticus induced by sleep in children 显示文摘 | PATRY G LYAGOUBI S TASSINARI C A | 1971 | Arch Neurol1971，24，4： | 1 |
| 14 | The effects of 48 weeks of rosiglitazone on hepatocyte mitochondria in human nonalcoholic steatohepatitis显示文摘 | Caldwell S H Patrie J T Brunt E M | 2007 | Hepatology2007，46，： | 1 |
| 15 | Studies on polysulfide and copolysulfide显示文摘 | Patri M Kole S Deb P C | 1992 | Journal of Polymer Materials1992，9，1： | 1 |
| 16 | A Transaction Cost Model of IT Outsourcing 显示文摘 | B Aubert S Rivard and M Patry | 2004 | Information & Management2004，41，7： | 1 |
| 17 | Subclinical 'electrical status epilepticus' induced by sleep in children显示文摘 | Patry G Lyagoubi S Tassinari CA | 1971 | Arch Neurol1971，24，4： | 1 |
| 18 | Profile design consideration for minimizing base transit time in SiGe HBT's 显示文摘 | Patri V S Kumar M J | 1998 | IEEE Trans on Electron Device1998，45，8： | 1 |
| 19 | Assessing the risk of IT outsourcing 显示文摘 | Aubert B A Patry M Rivard S | 1998 | Systems Science1998，，7： | 1 |
| 20 | Managing the risk of IT outsourcing 显示文摘 | Aubert B A Dussauh S Patry M | 1999 | Systems Science1999，，8： | 1 |
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