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| 1 | Pathogenesis and clinical management of Helicobacter pylori gastric infection显示文摘Helicobacter pylori(H.pylori)is a gram-negative bacterium that infects approximately 4.4 billion individuals worldwide.However,its prevalence varies among different geographic areas,and is influenced by several factors.The infection can be acquired by means of oral-oral or fecal-oral transmission,and the pathogen possesses various mechanisms that improve its capacity of mobility,adherence and manipulation of the gastric microenvironment,making possible the colonization of an organ with a highly acidic lumen.In addition,H.pylori presents a large variety of virulence factors that improve its pathogenicity,of which we highlight cytotoxin associated antigen A,vacuolating cytotoxin,duodenal ulcer promoting gene A protein,outer inflammatory protein and gamma-glutamyl transpeptidase.The host immune system,mainly by means of a Th1-polarized response,also plays a crucial role in the infection course.Although most H.pylori-positive individuals remain asymptomatic,the infection predisposes the development of various clinical conditions as peptic ulcers,gastric adenocarcinomas and mucosa-associated lymphoid tissue lymphomas.Invasive and non-invasive diagnostic methods,each of them with their related advantages and limitations,have been applied in H.pylori detection.Moreover,bacterial resistance to antimicrobial therapy is a major challenge in the treatment of this infection,and new therapy alternatives are being tested to improve H.pylori eradication.Last but not least,the development of effective vaccines against H.pylori infection have been the aim of several research studies. | Breno Bittencourt de Brito Filipe Ant?nio Fran?a da Silva Aline Silva Soares Vinícius Afonso Pereira Maria Luísa Cordeiro Santos Mariana Miranda Sampaio Pedro Henrique Moreira Neves Fabrício Freire de Melo | 2019 | World Journal of Gastroenterology2019，25，37： | 84 |
| 2 | Major regulatory mechanisms involved in sperm motility显示文摘涉及鞭子部件以及在 flagellar 运动的规定的汇编和函数的基因库和分子的机制充分没被理解,特别在人。为精子无法移动,一些能被避免并且改正有几个原因,而其它与基因缺点有关并且值得完整的调查把诊断给病人。这评论在科学的联机数据库 PubMed, ScienceDirect,和网上在广泛的文学搜索以后被执行。这里,我们考察为精子活动性负责的规章的小径的参与,显示为精子无法移动的可能的原因。这些包括了钙小径,营地依赖者蛋白质 kinase 小径, kinases 和磷酸酶的重要性,反应的氧种类的功能,并且房间体积和 osmolarity 的规定怎么也是基本部件。我们然后讨论与特定的词法畸形联系的主要基因缺点。最后,我们稍微讨论某预防措施和治疗途径避免与未特别指出的精子无法移动被联系的条件的开发。我们在不久的将来相信那,与更强大的技术,精子无法移动的基因原因和活动性将是的精子的规章的机制的发展更好理解,因此启用执行完整的诊断并且揭开新治疗。 | Rute Pereira Rosalia Sa Alberto Barros Mario Sousa | 2017 | Asian Journal of Andrology2017，19，1： | 12 |
| 3 | Value of the new hone classification system in pediatric renal osteodystrophy显示文摘 | Bakkaloglu SA Wesseling Perry K Pereira RC | 2010 | Clin J Am Soc Nephrol2010，5，10： | 1 |
| 4 | Surgial treatment of endomyocardial fibrosis:A new approach显示文摘 | Oliveira SA Pereira Barretto AC Mady C | 1990 | Am Coll Cardiol1990，16，： | 1 |
| 5 | Expression of IL-6, IL-10, IL-17 and IL-8 in the peri-implant crevicular fluid of patients with peridmplantitis显示文摘 | Severino VO Napimoga MH De Lima Pereira SA | 2011 | Arch Oral Biol2011，56，8： | 1 |
| 6 | Expression of IL-6, IL-10, IL-17 and IL-8 in the periimplant crevicular fluid of patients with peri-implantitis 显示文摘 | Severino VO Napimoga MH Lima Pereira SA | 2011 | Arch Oral Biol2011，56，8： | 1 |
| 7 | Donepezil: An Important Prototype to the Design of New Drug Candidates for Alzheimerμs Disease显示文摘 | Maria Cecilia Rodrigues Simoes Flavia Pereira Dias Viegas Marcella Soares Moreira Matheus de Freitas Silva Mariana Maximo Riquiel Patricia Mattos da Rosa Maísa Rosa Castelli Marcelo Henrique dos Santos Marisi Gomes Soares Claudio Viegas | 2014 | Mini-Reviews in Medicinal Chemistry2014，，1： | 1 |
| 8 | Eyelid entropion 显示文摘 | Pereira MG Rodrigues MA Rodrigues SA | 2010 | Semin Ophthalmol2010，25，3： | 1 |
| 9 | Expression of cell-cycle regulatory proteins and their prognostic value in superficial lowgrade urothelial cell carcinoma of the bladder 显示文摘 | Santos LL Amaro T Pereira SA | 2003 | Eur J Surg Oncol2003，29，1： | 1 |
| 10 | Pathophysiology and molecular aspects of diffuse large B-cell lymphoma显示文摘 | Gouveia GR Siqueira SA Pereira J | 2012 | Rev Bras Hematol Hemoter2012，34，6： | 1 |
| 11 | Expression of IL-6, IL-10, IL-17 and IL-8 in the peri-implant crevicular fluid of patients with peri- implantitis显示文摘 | Severino VO Napimoga MH de Lima Pereira SA | 2011 | Arch Oral Biol2011，56，8： | 1 |
| 12 | Expression of IL -6 , IL - 10 , IL - 17 and I L - 8 in the peri - implant crevicular fluid ofpatients with peri - implantitis显示文摘 | Severino VO Napimoga M H de Lima Pereira SA | | Arch Oral Biol0，56，8： | 1 |
| 13 | Immune response to Helicobacter pylori infection and gastric cancer development显示文摘Gastric adenocarcinoma is a global health concern,and Helicobacter pylori(H.pylori)infection is the main risk factor for its occurrence.Of note,the immune response against the pathogen seems to be a determining factor for gastric oncogenesis,and increasing evidence have emphasized several host and bacterium factors that probably influence in this setting.The development of an inflammatory process against H.pylori involves a wide range of mechanisms such as the activation of pattern recognition receptors and intracellular pathways resulting in the production of proinflammatory cytokines by gastric epithelial cells.This process culminates in the establishment of distinct immune response profiles that result from the cytokine-induced differentiation of T naïve cells into specific T helper cells.Cytokines released from each type of T helper cell orchestrate the immune system and interfere in the development of gastric cancer in idiosyncratic ways.Moreover,variants in genes such as single nucleotide polymorphisms have been associated with variable predispositions for the occurrence of gastric malignancy because they influence both the intensity of gene expression and the affinity of the resultant molecule with its receptor.In addition,various repercussions related to some H.pylori virulence factors seem to substantially influence the host immune response against the infection,and many of them have been associated with gastric tumorigenesis. | Breno Bittencourt de Brito Fabian Fellipe Bueno Lemos Caroline da Mota Carneiro Andressa Santos Viana Nilo Manoel Pereira Vieira Barreto Gabriela Alves de Souza Assis Barbara Dicarlo Costa Braga Maria Luísa Cordeiro Santos Filipe Antônio França da Silva Hanna Santos Marques Natália Oliveira e Silva Fabrício Freire de Melo | 2021 | World Journal of Meta-Analysis2021，9，3： | 1 |
| 14 | Expres- sion of IL- 6, IL -10, IL- 17 and IL 8 in the peri-implant crevicular fluid of patients with peri- implantitis 显示文摘 | Severino VO Napimoga MH de Lima Pereira SA | 2011 | Arch O- ral Biol2011，56，8： | 1 |
| 15 | Expression of IL- 6, IL-10, IL-17 and IL-8 in the peri-implant crevicular fluid of patients with peri-implantitis 显示文摘 | Severino VO Napimoga MH de Lima Pereira SA | 2011 | Arch Oral Biol2011，56，8： | 1 |
| 16 | Expression of IL-6,IL-10,IL-17 and IL-8 in the peri-implant crevicular fluid of patients with peri-implantitis显示文摘 | Severino VO Napimoga MH De Lima Pereira SA | 2011 | Arch Oral Biol2011，56，8： | 1 |
| 17 | Meiotic segrega- tion and interchromosomal effect in the sperm of adouble translocation carrier : a case report 显示文摘 | Juchniuk de Vozzi MS Santos SA Pereira CS | 2009 | Mol Cytogenet2009，1，2： | 1 |
| 18 | Effects of physical exercise in nasal volume显示文摘 | Fonseca MT Machado JA Pereira SA | 2006 | Braz J Otorhinolaryngol2006，72，2： | 1 |
| 19 | Blood pressure control and antihypertensive pharmacotherapy patterns in a hypertensive population of eastern central region of portugal显示文摘 | Morgado MP Rolo SA Pereira L | 2010 | BMC Health Serv Res2010，10，： | 1 |
| 20 | Expression of cell-cycle regulatory proteins and their prognostic value in superficial low-grade urothelial cell carcinoma of the blad- der 显示文摘 | Santos LL Amaro T Pereira SA | 2003 | Eur J Surg Oncol2003，29，1： | 1 |
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