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| 1 | Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis显示文摘AIM To investigate the effects of orally gavaged aqueous rhubarb extract(RE) on 5-fluorouracil(5-FU)-induced intestinal mucositis in rats. METHODS Female Dark Agouti rats(n = 8/group) were gavaged daily(1 mL) with water, high-dose RE(HDR; 200 mg/kg) or low-dose RE(LDR; 20mg/kg) for eight days. Intestinal mucositis was induced(day 5) with 5-FU(150 mg/kg) via intraperitoneal injection. Intestinal tissue samples were collected for myeloperoxidase(MPO) activity and histological examination. Xenopus oocytes expressing aquaporin 4 water channels were prepared to examine the effect of aqueous RE on cell volume, indicating a potential mechanism responsible for modulating net fluid absorption and secretion in the gastrointestinal tract. Statistical significance was assumed at P < 0.05 by one-way ANOVA. RESULTS B o d y w e i g h t w a s s i g n i f i c a n t l y r e d u c e d i n r a t s administered 5-FU compared to healthy controls(P < 0.01). Rats administered 5-FU significantly increased intestinal MPO levels(≥ 307%; P < 0.001), compared to healthy controls. However, LDR attenuated this effect in 5-FU treated rats, significantly decreasing ileal MPO activity(by 45%; P < 0.05), as compared to 5-FU controls. 5-FU significantly reduced intestinal mucosal thickness(by ≥ 29% P < 0.001) as compared to healthy controls. LDR significantly increased ileal mucosal thickness in 5-FU treated rats(19%; P < 0.05) relative to 5-FU controls. In xenopus oocytes expressing AQP4 water channels, RE selectively blocked water influx into the cell, induced by a decrease in external osmotic pressure. As water efflux was unaltered by the presence of extracellular RE, the directional flow of water across the epithelial barrier, in the presence of extracellular RE, indicated that RE may alleviate water loss across the epithelial barrier and promote intestinal health in chemotherapy-induced intestinal mucositis.CONCLUSION In summary, low dose RE improves selected parameters of mucosal integrity and reduces ileal inflammation, manifesting from 5-FU-induced intestinal mucositis. | Juliana E Bajic Georgina L Eden Lorrinne S Lampton Ker Y Cheah Kerry A Lymn Jinxin V Pei Andrea J Yool Gordon S Howarth | 2016 | World Journal of Gastroenterology2016，22，37： | 3 |
| 2 | Old Age Support in China: The Role of the State and the Family显示文摘 | PEI X M PILLAI V K | 1999 | The International Journal of Aging and Human Development1999，49，3： | 1 |
| 3 | Engineering of functional cartilage tissue using stem cells from synovial lining : a preliminary study显示文摘 | Pei M H e F Kish V L | 2008 | Clin Orthop Relat Res2008，466，8： | 1 |
| 4 | Old Age Support in China: The Role of the State and the Family 显示文摘 | PEI X PILLAI V K | 1999 | International Journal of Aging and Human Development1999，49，3： | 1 |
| 5 | A moleculardynamics study of the mechanical properties of hydrogenfiinctionalized graphene显示文摘 | PEI Q X ZHANG Y W SHENOY V B | 2010 | Carbon2010，48，3： | 1 |
| 6 | SiCp/Ti6Al4V functionally graded materials produced by laser melt injection显示文摘 | PEI Y T OCELIK V De HOSSON J T M | 2002 | Acta Materialia2002，50，8： | 1 |
| 7 | Pushing convertible constraints in frequent itemset mining显示文摘 | Pei Jian Han Jiawei Lakshmanan L V S | 2004 | Data Mining and Knowledge Discovery2004，，8： | 1 |
| 8 | Interfacial adhesion of laser clad functionally graded materials显示文摘 | PEI Y T OCELIK V DE HOSSON J T M | 2003 | Mater Sci Eng A2003，342，12： | 1 |
| 9 | Type l-I CAAX prenyl endopeptidases belong to a novel superfamily of putative membrane-bound metallo- proteases显示文摘 | Pei J Grishin N V | 2001 | Trends in Biochemical Sciences2001，26，5： | 1 |
| 10 | Laser melt injection in aluminum alloys: On the role of the oxide skin显示文摘 | VREELING J A OCELIK V PEI Y T | 2000 | Acta Mater2000，48，17： | 1 |
| 11 | Time dependence of bioactive compounds and antioxidant capacity during germination of different cultivars of broccoli and radish seeds显示文摘 | MARTINEZ V C PEI~IAS E CISKA E | 2010 | Food Chemistry2010，120，3： | 1 |
| 12 | SiCp/Ti6Al4V functionally graded materials produced by laser melt injection显示文摘 | Pei Y T Ocelik V De Hosson J Th M | 2002 | Acta Mater2002，50，： | 1 |
| 13 | RNAi screen of endoplasmic reticulum-associated host factors reveals a role for IRE1 alpha in supporting Brucella replication显示文摘 | Qin Q M Pei J W Ancona V | 2008 | PLoS Pathogens (Online)2008，4，10： | 1 |
| 14 | PROMALS : towards accurate multiple sequence alignments of distantly related proteins 显示文摘 | PEI J GRISHIN N V | 2007 | Bioinformatics2007，23，7： | 1 |
| 15 | PCMA:fast and accurate multiple sequence alignment based on profile consistency显示文摘 | PEI J SADREYEV R GRISHIN N V | 2003 | Bioinformatics2003，19，3： | 1 |
| 16 | MUMMALS, multiple sequence alignment improved by using hidden Markov models with local structural information显示文摘 | PEI J GRISHIN N V | 2006 | Nucleic Acids Res2006，34，16： | 1 |
| 17 | Ink-jetted silver/copper conductors for printed RFID appli-cations 显示文摘 | Volkman S K Pei Y Redinger D Yin S Subramanian V | 2004 | Materials Research Society Symposium Pro-ceedings2004，814，： | 1 |
| 18 | A novel parameter iden- tification approach via hybrid learning for aggregate load modeling 显示文摘 | Bai Hua Zhang Pei Ajjarapu V | 2009 | IEEE Transactions on Power Systems2009，24，3： | 1 |
| 19 | PROMALS: towards accurate multiple sequence alignments of distantly related proteins 显示文摘 | PEI J GRISHIN N V | 2007 | Bioinformatics2007，23，7： | 1 |
| 20 | PROMALS3D:a tool for multiple protein sequence and structure alignments显示文摘 | PEI J KIM B H GRISHIN N V | 2008 | Nucl Acids Res2008，36，7： | 1 |
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