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| 1 | Relationship between the exocrine and endocrine pancreas after acute pancreatitis显示文摘AIM:To determine the prevalence and time course of pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.METHODS:Relevant literature cited in three major biomedical journal databases(EMBASE,MEDLINE,and Scopus)was reviewed independently by two authors.There were no language constraints but the search was limited to human studies.Studies included were cohort studies of adult patients who were discharged after an attack of acute pancreatitis.Patients were excluded if they were under 18 years of age or had a previous diagnosis of prediabetes or diabetes mellitus,pancreatic exocrine insufficiency,or chronic pancreatitis.The main outcome measure was the prevalence of concomitant pancreatic exocrine insufficiency in patients who were diagnosed with prediabetes and diabetes mellitus after an attack of acute pancreatitis.Subgroup analysis was conducted for patients who were diagnosed with prediabetes only and those who were diagnosed withdiabetes mellitus only.Subgroup analysis looking at the time course of concomitant pancreatic exocrine and endocrine insufficiency was also conducted.Pooled prevalence and corresponding 95%confidence intervals were calculated for all outcome measures and P-values<0.05 were deemed statistically significant.RESULTS:Eight clinical studies comprising of 234patients met all eligibility criteria.The pooled prevalence of newly diagnosed prediabetes or diabetes in individuals after acute pancreatitis was 43%(95%CI:30%-56%).The pooled prevalence of pancreatic exocrine insufficiency in individuals after acute pancreatitis was 29%(95%CI:19%-39%).The prevalence of concomitant pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes was 40%(95%CI:25%-55%).The prevalence of concomitant pancreatic exocrine insufficiency among individuals with prediabetes alone and diabetes mellitus alone was 41%(95%CI:12%-75%)and 39%(95%CI:28%-51%),respectively.Further analysis showed that the prevalence of concomitant pancreatic exocrine insufficiency in individuals with prediabetes or diabetes decreases over time after an attack of acute pancreatitis.CONCLUSION:Pancreatic exocrine insufficiency occurs in 40%of individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.Further studies are needed to investigate the pathogenesis of diabetes in this setting. | Stephanie L M Das James I C Kennedy Rinki Murphy Anthony R J Phillips John A Windsor Maxim S Petrov | 2014 | World Journal of Gastroenterology2014，20，45： | 9 |
| 2 | Green tea extract:A potential cause of acute liver failure显示文摘The use of herbal products has increased significantly in recent years.Because these products are not subject to regulation by the Food and Drug Administration and are often used without supervision by a healthcare provider,the indication for and consumption of these supplements is quite variable.Moreover,their use is generally regarded as safe and natural by the lay-public.Unfortunately,there has been an increase in the number of reported adverse events occurring with the use of herbal products.We present a case of acute impending liver failure in an adolescent male using a weightloss product containing green tea extract.Our case adds to the growing concern surrounding the ingestion of green tea extract and serves to heighten healthcare provider awareness of a potential green tea extract hepatotoxicity.Despite the generally touted benefits of green tea as a whole,clinical concern regarding its use is emerging and has been linked to its concentration in multiple herbal supplements.Interestingly,the suspected harmful compounds are those previously proposed to be advantageous for weight-loss,cancer remedy,and anti-inflammatory purposes.Yet,we emphasize the need to be aware of not just green tea extract,but the importance of monitoring patient use of all dietary supplements and herbal products. | Shreena S Patel Stacey Beer Debra L Kearney Garrett Phillips Beth A Carter | 2013 | World Journal of Gastroenterology2013，19，31： | 3 |
| 3 | 1400W reduces ischemia reperfusion injury in an ex-vivo porcine model of the donation after circulatory death kidney donor显示文摘AIM: To investigate the effects of 1400W-a selective inducible nitric oxide synthase(iN OS) inhibitor in a model of donation after circulatory death(DCD) kidneys. METHODS: Porcine kidneys were retrieved after 25 min warm ischemia. They were then stored on ice for 18 h before being reperfused ex vivo with oxygenated autologous blood on an isolated organ perfusion system. The selective i NOS inhibitor 1400W(10 mg/kg) was administered before reperfusion(n = 6) vs control group(n = 7). Creatinine(1000 μmol/L) was added to the system, renal and tubular cell function and the level of ischemia reperfusion injury were assessed over 3 h of reperfusion using plasma, urine and tissue samples. RESULTS: Kidneys treated with 1400 W had a higher level of creatinine clearance(CrC l) [area under the curve(AUC) CrC l: 2.37 ± 0.97 mL /min per 100 g vs 0.96 ± 0.32 mL /min per 100 g, P = 0.004] and urine output [Total: 320 ± 96 mL vs 156 ± 82 mL, P = 0.008]. There was no significant difference in levels of fractional excretion of sodium(AUC, Fr ex Na+: Control, 186.3% ± 81.7%.h vs 1400 W, 153.4% ± 12.1%.h, P = 0.429). Levels of total protein creatinine ratio were significantly lower in the 1400 W group after 1 h of reperfusion(1h Pr/Cr: 1400 W 9068 ± 6910 mg/L/mmol/L vs Control 21586 ± 5464 mg/L/mmol/L, P = 0.026). Levels of 8-isoprostane were significantly lower in the 1400 W group [8-iso/creatinine ratio: Control 239 ± 136 pg/L/mmol/L vs 1400 W 139 ± 47 pg/L/mmol/L, P = 0.041].CONCLUSION: This study demonstrated that 1400 W reduced ischaemia reperfusion injury in this porcine kidney model of DCD donor. Kidneys had improved renal function and reduced oxidative stress. | Sarah A Hosgood Phillip J Yates Michael L Nicholson | 2014 | World Journal of Transplantation2014，4，4： | 2 |
| 4 | An angiogenic extract from skeletal muscle stimulates monoeyte and endothelial cell chemotaxis in vitro显示文摘 | Phillips G D Sehilb L A Fiegel V D | 1991 | Proe Soe Exp Biol Med1991，197，4： | 1 |
| 5 | The Brown Assessment of Be- liefs Scale: Reliability and validity显示文摘 | Eisen J L Phillips K A Baer L | 1998 | Am J Psychiatry1998，155，1： | 1 |
| 6 | Determination of organic acids in Vaccinium berry standard reference materials显示文摘 | Phillips M M Case R J Rimmer C A Sander L C Sharpless K E Wise S A Yen J H | 2010 | Analytical and Bioanalytical Chemistry2010，398，1： | 1 |
| 7 | Storage of Light in Atomic Vapor显示文摘 | Phillips D F Fleischhauer A Mair A Walsworth R L Lukin M D | 2001 | Phys Rev Lett2001，86，78： | 1 |
| 8 | Effect of temperature on microbial growth rate-mathematical analysis :the Arrhenius and Eyring-Polanyi connections显示文摘 | HUANG L HWANG A PHILLIPS J | 2011 | Journal of Food Science2011，76，8： | 1 |
| 9 | Systolic blood pressure varia- bility and carotid artery damage in hypertension:Baseline date from the European Lacidipine Study on Atherosclerosis(ELSA) 显示文摘 | Mancia G Phillips C Thijs L et a l | 2001 | J Hypertens2001，19，11： | 1 |
| 10 | Molecular basis for familial isolated growth hormone deficiency显示文摘 | PHILLIPS J A 3rd HJELLE B L SEEBURG P H | 1981 | Proc Natl Acad Sci U S A1981，78，： | 1 |
| 11 | Resolving the phylogenetic and taxonomic status of dark-spored teleomorph genera in the Botryosphaeriaceae 显示文摘 | Phillips A J L Alves A Pennycook S R | 2008 | Persoonia2008，21，： | 1 |
| 12 | Dolomitization front geometry,fluid flow patterns and the origin of massive dolomite 显示文摘 | Wilson E N Hardie L A Phillips O M | 1990 | America Journal of Science1990，290，5： | 1 |
| 13 | The Botryosp haeriaceae: genera and species known from cuhure显示文摘 | Phillips A J L Alves A Abdollahzadeh J | 2013 | Mycology2013，76，1： | 1 |
| 14 | Porcine oxymyoglobin and lipid oxidation in vitro显示文摘 | LEE S PHILLIPS A L LIEBLER D C | 2003 | Meat Science2003，63，： | 1 |
| 15 | Gibberellin metabolism: new in- sights revealed by the genes显示文摘 | Hedden P Phillips A L | 2000 | Trends Plant Sci2000，5，： | 1 |
| 16 | Characterisation and epitypification of Botryosphaeria corticis,the cause of blue- berry cane canker显示文摘 | Phillips A J L Oudemans P V Correia A | 2006 | Fungal Diversity2006，21，： | 1 |
| 17 | The identification of predictors of psychosis in a high risk group 显示文摘 | MCGORRY P D PHILLIPS L J YUNG A R | 1999 | Schizophr Res1999，36，1： | 1 |
| 18 | Surgical strategy for cystic diseases of the liver in a Western Hepatobiliary Center显示文摘 | Basil A J Benjamin L J Phillip C M | 2002 | World J Surg2002，26，4： | 1 |
| 19 | Evaluation of a fully covered self-ex- pandable metal stent in liver transplant patients with bile leaks : mid-term analysis 显示文摘 | Phillips M S Saue B Bonatti H Rehan M E Smith L A Ellen K | 2009 | Gastrointest Endosc2009，69，： | 1 |
| 20 | Competition and spacing patterns in desert shrubs显示文摘 | Phillips D L MacMahon J A | | 0，，： | 1 |
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