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| 1 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 2 | Construction of an oilseed rape (Brassica napus L.) genetic map with SSR markers显示文摘 | J. Piquemal E. Cinquin F. Couton C. Rondeau E. Seignoret I. doucet D. Perret M.-J. Villeger P. Vincourt P. Blanchard | 2005 | Theoretical and Applied Genetics2005，，8： | 2 |
| 3 | NMR characterization of altered lignins extracted from tobacco plants down-regulated for lignification enzymes cinnamylalcohol dehydrogenase and cinnamoyl-CoA reductase显示文摘 | RALPH J HATFIELD R D PIQUEMAL J | 1998 | Proc Natl Acad Sci USA1998，95，12： | 1 |
| 4 | Improved paper pulp from plants with suppressed cinnamoyl-CoA reductase or cinnamy alcohol dehydrogenase显示文摘 | Oconnell A Holt K Piquemal J | 2002 | Transgenie Res2002，11，： | 1 |
| 5 | Down-regulation of caffeic acid O-methyhransferase in maize revisited using a transgenic approach显示文摘 | Piquemal J Chamayou S Nadaud I | 2002 | Plant Physiol2002，130，4： | 1 |
| 6 | One-step Construction of Silver Nanowires in Hexagonal Mesoporous Silica Using the Polyol Process显示文摘 | Guillaume Vian Partricia Beaunier | 2003 | Materials Research Bulletin2003，38，3： | 1 |
| 7 | Down- regulation of Cinnamoyl CoA reductase induces significantchanges of lignin profiles in transgenic tobacco plants显示文摘 | PIQUEMAL J L LAPIERRE C MYTON K | 1998 | The Plant Journal1998，13，1： | 1 |
| 8 | Environmentally friendly epoxidation of olefins under phase-transfer catalysis conditions with hydrogen peroxide显示文摘 | Yahdih Mahha Laurent Salles Jean-Yves Piquemal Emmanuel Briot Ahmed Atlamsani Jean-Marie Br e geault | 2007 | J Catal2007，，249： | 1 |
| 9 | Differential expression of the RTP/Dr91/Ndrl gene product in proliferating and growth arrested cells显示文摘 | Piquemal D Joulia D Balaguer P | | 0，，3： | 1 |
| 10 | Using inorganic silicate precursor/molybdenum peroxo complexes/onium salt interfaces in aqueous acidic media to design mesoporous silica with high molybdenum content and high dispersion显示文摘 | PIQUEMAL J Y MANOLI J M BEAUNIER P ENSUQUE A TOUGNE P LEGRAND A P BREGEAULT J M | 1999 | Microporous Mesopurous Mater1999，29，3： | 1 |
| 11 | Enforcing hemidirec- tionality in Pb( 1I ) complexes:the importance of anionic ligands 显示文摘 | Severen M C V Piquemal J P Parisel O | 2011 | Chemical Physics Letters2011，10，23： | 1 |
| 12 | Charaeterisation of as-synthesised Mox-MCM-41 ( M = Mo, W) mesophases using ramanspectrometry and 29Si MAS NMR显示文摘 | PIQUEMAL J Y BRIOT E CHOTTARD G TOUGNE P MANOLI J M BREGEAULT J M | 2003 | Microporous Mesoporous Mater2003，58，3： | 1 |
| 13 | Improved paper pulp from planhs with suppressed cinnamoyl--CoA reduc- tase or cinnamyI alcohol dehydrogenase 显示文摘 | O' ConneU A Hoh K Piquemal J | 2002 | Trans Res2002，11，49： | 1 |
| 14 | Comparison of the conventional impregnation method using ammonium heptamolybdate with a simple route to silica-supported molybdenum (Ⅵ) materials显示文摘 | BAKALA P C BRIOT E PIQUEMAL J Y BREGEAULT J M BEAUNIER P | 2007 | Catal Commun2007，8，10： | 1 |
| 15 | Synthesis and interfacial properties of montmorillonite/polypyrrole nanocomposites显示文摘 | BOUKERMA K PIQUEMAL J Y CHEHIMI M M | 2006 | Polymer2006，47，2： | 1 |
| 16 | Downregulation of cinnamoyl CoA reductase induces significant changes of lignin profiles in transgenic tobacco plants 显示文摘 | PIQUEMAL J LAP IERRE C MYTON K | 1998 | The Plant Journal1998，13，： | 1 |
| 17 | Growth rate of four freshwater algae in relation to light and temperature显示文摘 | Dauta A Devaux J Piquemal F Boumnich L | 1990 | Hydrobiologia1990，207，： | 1 |
| 18 | Aqueous acidic hydrogen as an efficient medium for tungsten insertion into MCM-41 mesoporous molecular sieves with high metal dispersion 显示文摘 | Emmanuel Briot Piquemal Jean-Yves Maxenee Vennat | 2000 | J Mater Chem2000，10，： | 1 |
| 19 | Using inorganic silicate precursor/molybdenum peroxo complexes/onium salt interfaces in aqueous acidic media to design mesoporous silica with high molybdenum content and high dispersion 显示文摘 | Piquemal J Y Manoli J M Beaunier P | 1999 | Micro Meso Mater1999，29，： | 1 |
| 20 | Formation of assembled silver nanowires by reduction of silver thiolate in polyol/toluene medium显示文摘 | Guillaume Viau Jean-Yves Piquemal Marta Esparrica | 2003 | Chemical Communications2003，3，17： | 1 |
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