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| 1 | The divergent roles of autophagy in ischemia and preconditioning显示文摘 | Rui SHENG Zheng-hong QIN | 2015 | Acta Pharmacologica Sinica2015，36，4： | 25 |
| 2 | An economic and low-carbon day-ahead Pareto-optimal scheduling for wind farm integrated power systems with demand response显示文摘Demand response(DR)and wind power are beneficial to low-carbon electricity to deal with energy and environmental problems.However,the uncertain wind power generation(WG)which has anti-peaking characteristic would be hard to exert its ability in carbon reduction.This paper introduces DR into traditional unit commitment(UC)strategy and proposes a multi-objective day-ahead optimal scheduling model for wind farm integrated power systems,since incentive-based DR can accommodate excess wind power and can be used as a source of system spinning reserve to alleviate generation side reserve pressure during both peak and valley load periods.Firstly,net load curve is obtained by forecasting load and wind power output.Then,considering the behavior of DR,a day-ahead optimal dispatching scheme is proposed with objectives of minimum generating cost and carbon emission.Non-dominated sorting genetic algorithm-II(NSGA-II)and satisfaction-maximizing method are adopted to solve the multi-objective model with Pareto fronts and eclectic decision obtained.Finally,a case study is carried out to demonstrate that the approach can achieve economic and environmental aims and DR can help to accommodate the wind power. | Rui MA Kai LI Xuan LI Zeyu QIN | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，3： | 20 |
| 3 | Exogenous NADPH ameliorates myocardial ischemia–reperfusion injury in rats through activating AMPK/mTOR pathway显示文摘Our previous study shows that nicotinamide adenine dinucleotide phosphate(NADPH)plays an important role in protecting against cerebral ischemia injury.In this study we investigated whether NADPH exerted cardioprotection against myocardial ischemia/reperfusion(I/R)injury.To induce myocardial I/R injury,rats were subjected to ligation of the left anterior descending branch of coronary artery for 30 min followed by reperfusion for 2 h.At the onset of reperfusion,NADPH(4,8,16 mg·kg?1·d?1,iv)was administered to the rats.We found that NADPH concentrations in plasma and heart were signi?cantly increased at 4 h after intravenous administration.Exogenous NADPH(8?16 mg/kg)signi?cantly decreased myocardial infarct size and reduced serum levels of lactate dehydrogenase(LDH)and cardiac troponin I(cTn-I).Exogenous NADPH signi?cantly decreased the apoptotic rate of cardiomyocytes,and reduced the cleavage of PARP and caspase-3.In addition,exogenous NADPH reduced mitochondrial vacuolation and increased mitochondrial membrane protein COXIV and TOM20,decreased BNIP3L and increased Bcl-2 to protect mitochondrial function.We conducted in vitro experiments in neonatal rat cardiomyocytes(NRCM)subjected to oxygen–glucose deprivation/restoration(OGD/R).Pretreatment with NADPH(60,500 nM)signi?cantly rescued the cell viability and inhibited OGD/R-induced apoptosis.Pretreatment with NADPH signi?cantly increased the phosphorylation of AMPK and downregulated the phosphorylation of mTOR in OGD/R-treated NRCM.Compound C,an AMPK inhibitor,abolished NADPH-induced AMPK phosphorylation and cardioprotection in OGD/R-treated NRCM.In conclusion,exogenous NADPH exerts cardioprotection against myocardial I/R injury through the activation of AMPK/mTOR pathway and inhibiting mitochondrial damage and cardiomyocyte apoptosis.NADPH may be a potential candidate for the prevention and treatment of myocardial ischemic diseases. | Jiang Zhu Yi-fei Wang Xiao-ming Chai Ke Qian Ling-wei Zhang Peng Peng Pei-min Chen Jian-fang Cao Zheng-hong Qin Rui Sheng Hong Xie | 2020 | Acta Pharmacologica Sinica2020，41，4： | 19 |
| 4 | The endoplasmic reticulum stress inhibitor salubrinal inhibits the activation of autophagy and neuroprotection induced by brain ischemic preconditioning显示文摘 | Bo GAO Xiang-yang ZHANG Rong HAN Tong-tong ZHANG Cheng CHEN Zheng-hong QIN Rui SHENG | 2013 | Acta Pharmacologica Sinica2013，34，5： | 19 |
| 5 | A Deep Learning Method for Bias Correction of ECMWF 24–240 h Forecasts显示文摘Correcting the forecast bias of numerical weather prediction models is important for severe weather warnings.The refined grid forecast requires direct correction on gridded forecast products,as opposed to correcting forecast data only at individual weather stations.In this study,a deep learning method called CU-net is proposed to correct the gridded forecasts of four weather variables from the European Centre for Medium-Range Weather Forecast Integrated Forecasting System global model(ECMWF-IFS): 2-m temperature,2-m relative humidity,10-m wind speed,and 10-m wind direction,with a forecast lead time of 24 h to 240 h in North China.First,the forecast correction problem is transformed into an image-toimage translation problem in deep learning under the CU-net architecture,which is based on convolutional neural networks.Second,the ECMWF-IFS forecasts and ECMWF reanalysis data(ERA5) from 2005 to 2018 are used as training,validation,and testing datasets.The predictors and labels(ground truth) of the model are created using the ECMWF-IFS and ERA5,respectively.Finally,the correction performance of CU-net is compared with a conventional method,anomaly numerical correction with observations(ANO).Results show that forecasts from CU-net have lower root mean square error,bias,mean absolute error,and higher correlation coefficient than those from ANO for all forecast lead times from 24 h to 240 h.CU-net improves upon the ECMWF-IFS forecast for all four weather variables in terms of the above evaluation metrics,whereas ANO improves upon ECMWF-IFS performance only for 2-m temperature and relative humidity.For the correction of the 10-m wind direction forecast,which is often difficult to achieve,CU-net also improves the correction performance. | Lei HAN Mingxuan CHEN Kangkai CHEN Haonan CHEN Yanbiao ZHANG Bing LU Linye SONG Rui QIN | 2021 | Advances in Atmospheric Sciences2021，38，9： | 15 |
| 6 | Management of granulomatous lobular mastitis: an international multidisciplinary consensus(2021 edition)显示文摘Granulomatous lobular mastitis(GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the evidence.Levels of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions,etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology.The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidencebased consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM. | Qian-Qian Yuan Shu-Yuan Xiao Omar Farouk Yu-Tang Du Fereshte Sheybani Qing Ting Tan Sami Akbulut Kenan Cetin Afsaneh Alikhassi Rami Jalal Yaghan Irmak Durur-Subasi Fatih Altintoprak Tae Ik Eom Fatih Alper Mustafa Hasbahceci David Martínez-Ramos Pelin Seher Oztekin Ava Kwong Cedric W.Pluguez-Turul Kirstyn EBrownson Shirish Chandanwale Mehran Habib Liu-Yi Lan Rui Zhou Xian-Tao Zeng Jiao Bai Jun-Wen Bai Qiong-Rong Chen Xing Chen Xiao-Ming Zha Wen-Jie Dai Zhi-Jun Dai Qin-Yu Feng Qing-Jun Gao Run-Fang Gao Bao-San Han Jin-Xuan Hou Wei Hou Hai-Ying Liao Hong Luo Zheng-Ren Liu Jing-Hua Lu Bin Luo Xiao-Peng Ma Jun Qian Jian-Yong Qin Wei Wei Gang Wei Li-Ying Xu Hui-Chao Xue Hua-Wei Yang Wei-Ge Yang Chao-Jie Zhang Fan Zhang Guan-Xin Zhang Shao-Kun Zhang Shu-Qun Zhang Ye-Qiang Zhang Yue-Peng Zhang Sheng-Chu Zhang Dai-Wei Zhao Xiang-Min Zheng Le-Wei Zheng Gao-Ran Xu Wen-Bo Zhou Gao-Song Wu | 2022 | Military Medical Research2022，9，4： | 13 |
| 7 | Glycyrrhizic acid attenuates CCl_4-induced hepatocyte apoptosis in rats via a p53-mediated pathway显示文摘AIM: To investigate the effect of glycyrrhizic acid (GA) on carbon tetrachloride (CCl4)-induced hepatocyte apo-ptosis in rats via a p53-dependent mitochondrial path-way. METHODS: Forty-five male Sprague-Dawley rats were randomly and equally divided into three groups, the control group, the CCl4 group, and the GA treatment group. To induce liver fibrosis in this model, rats were given a subcutaneous injection of a 40% solution of CCl4 in olive oil at a dose of 0.3 mL/100 g body weight biweekly for 8 wk, while controls received the same isovolumetric dose of olive oil by hypodermic injection, with an initial double-dose injection. In the GA group,rats were also treated with a 40% solution of CCl4 plus 0.2% GA solution in double distilled water by the intraperitoneal injection of 3 mL per rat three times a week from the first week following previously published methods, with modifications. Controls were given the same isovolumetric dose of double distilled water. Liver function parameters, such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were de-termined. Pathologic changes in the liver were detected by hematoxylin and eosin staining. Collagen fibers were evaluated by Sirius red staining. Hepatocyte apoptosis was investigated using the terminal deoxynucleotidyl transferase-mediated deoxyuridine 5-triphosphate nick end labeling (TUNEL) assay and the cleaved caspase-3 immunohistochemistry assay. The expression levels of p53 and apoptosis-related proteins were evaluated by immunohistochemistry or Western blotting analysis. RESULTS: After 8 wk of treatment, GA significantly re-duced serum activity of ALT (from 526.7 ± 57.2 to 342 ± 44.8, P<0.05) and AST (from 640 ± 33.7 to 462.8 ± 30.6, P<0.05), attenuated the changes in liver his-topathology and reduced the staging score (from 3.53 ± 0.74 to 3.00 ± 0.76, P<0.05) in CCl4 -treated rats. GA markedly reduced the positive area of Sirius red and the ratio of the hepatic fibrotic region (from 7.87% ± 0.66% to 3.68% ± 0.32%, P<0.05) compared with the CCl4 group. GA also decreased the expression level of cleaved caspase-3 compared to the CCl4 group. TU-NEL assay indicated that GA significantly diminished the number of TUNEL-positive cells compared with the CCl4 group (P<0.05). GA treatment clearly decreased the level of p53 (P<0.05) detected by immunohis-tochemistry and Western blotting analysis. Compared with the CCl4 group, we also found that GA reduced the Bax/Bcl-2 ratio (P<0.05), the expression of cleaved caspase-3 (P<0.05), cleaved caspase-9 (P<0.05), and inhibited cytochrome C and second mitochondria-derived activator of caspases (Smac) release from mito-chondria to cytoplasm, i.e. , GA reduced the expressionlevel of Smac, which inhibited c-IAP1 activity (P<0.05), ultimately inhibiting the activity of caspase-3, according to Western blotting analysis. As a result, GA suppressed activation of the caspase cascades and prevented he-patocyte apoptosis. | Xiao-Ling Guo Bo Liang Xue-Wei Wang Fu-Gang Fan Jing Jin Rui Lan Jing-Hui Yang Xiao-Chun Wang Lei Jin Qin Cao | 2013 | World Journal of Gastroenterology2013，19，24： | 12 |
| 8 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 9 | CD133^+ gallbladder carcinoma cells exhibit self-renewal ability and tumorigenicity显示文摘AIM:To identify cancer stem cells(CSCs) in human gallbladder carcinomas(GBCs).METHODS:Primary GBC cells were cultured under serum-free conditions to produce floating spheres.The stem-cell properties of the sphere-forming cells,including self-renewal,differentiation potential,chemoresistance and tumorigenicity,were determined in vitro or in vivo.Cell surface expression of CD133 was investigated in primary tumors and in spheroid cells using flow cytometry.The sphere-colony-formation ability and tumorigenicity of CD133+ cells were assayed.RESULTS:In vitro culture experiments revealed thatfloating spheroids were generated from primary GBC cells,and these sphere-forming cells could generate new progeny spheroids in serum-free media.Spheroid cells were differentiated under serum-containing conditions with downregulation of the stem cell markers Oct-4,Nanog,and nestin(P < 0.05).The differentiated cells showed lower spheroid-colony-formation ability than the original spheroid cells(P < 0.05).Spheroid cells were more resistant to chemotherapeutic reagents than the congenetic adherent cells(P < 0.05).Flow cytometry showed enriched CD133+ population in sphereforming cells(P < 0.05).CD133+ cells possessed high colony-formation ability than the CD133-population(P < 0.01).CD133+ cells injected into nude mice revealed higher tumorigenicity than their antigen-negative counterparts(P < 0.05).CONCLUSION:CD133 may be a cell surface marker for CSCs in GBC. | Cheng-Jian Shi Jun Gao Min Wang Xin Wang Rui Tian Feng Zhu Ming Shen Ren-Yi Qin | 2011 | World Journal of Gastroenterology2011，17，24： | 11 |
| 10 | Plumbagin inhibits cell growth and potentiates apop-tosis in human gastric cancer cells -in vitro through the NF-KB signaling pathway显示文摘 | Jing LI Lin SHEN Fu-rong LU You QIN Rui CHEN Jia LI fan LI Han-zi ZHAN Yuan-qiao HE | 2012 | Acta Pharmacologica Sinica2012，33，2： | 11 |
| 11 | OsRFPH2-10, a RING-H2 Finger E3 Ubiquitin Ligase, Is Involved in Rice Antiviral Defense in the Early Stages of Rice dwarf virus Infection显示文摘 | Lifang Liu Lian Jin Xiahe Huang Yongtao Geng Feng Li Qingqing Qin Rui Wang Shaoyi Ji Shanshan Zhao Qi Xie Chunhong Wei Can Xie Biao Ding Yi Li | 2014 | Molecular Plant2014，7，6： | 11 |
| 12 | Synergistic effects of prostaglandin E1 and lithium in a rat model of cerebral ischemia显示文摘瞄准:热吃惊蛋白质(HSP ) 是细胞的幸存的重要管理者并且对服的局部缺血施加 neuroprotective 效果。前列腺素 El (PGE1 ) 和锂被报导了保护神经原免于是化学家损害。如果锂能加强,现在的学习被承担检验对服的局部缺血的 PGE1 的 neuroprotection,并且如果合作效果发生在 HSP 的水平。方法:大脑局部缺血被永久中间的服的动脉吸藏(pMCAO ) 在老鼠导致。老鼠立即是有为 2 d 和 PGE1 的一个单个静脉内的政府的锂的下的注射的 pretreated 在以后化学家侮辱。每个组的 Cerebrocortical 血流动仔细在外科的操作以后在局部缺血, 5 min, 15 min, 30 min 和 60 min 的发作以前被监视。身体温度以前被测量,在 pMCAO 的发作以后的 5 min, 2 h 和 24 h。梗塞体积,大脑浮肿和马达行为赤字被分析 24 h 在以后化学家侮辱。Cytoprotective HSP70 并且他我在 ipsilateral 半球的条纹弦音器的 oxygenase-1 (HO-1 ) 被弄污的免疫检测。从 ipsilateral 半球的条纹弦音器的大脑节是有 anti-HSP70 抗体和 4,6-diamidino-2-phenylindole (DAPI ) 的双 labeled。结果:有 PGE1 的处理(8 和 16 μg/kg, iv ) 或锂(0.5 mEq/kg, sc ) 独自减少的梗塞体积,神经病学的赤字和大脑浮肿在老鼠由焦点的服的局部缺血导致了。而且,当 PGE1 和锂一起被给时,更大的 neuroprotection 被观察。显著地,在调整 cytoprotective 上面, HSP70 和 HO-1 蛋白质铺平的 PGE1 和锂的合作管理。结论:锂和 PGE1 可以在服的局部缺血的处理施加 synergistic 效果并且可以因此为击的处理有潜在的临床的价值。 | Rong HAN Bo GAO Rui SHENG Li-sha ZHANG Hui-lin ZHANG Zhen-lun GU Zheng-hong QIN | 2008 | Acta Pharmacologica Sinica2008，29，10： | 10 |
| 13 | Antitumor effects of Chi-Shen extract from Salvia miltiorrhiza and Paeoniae radix on human hepatocellular carcinoma cells显示文摘目的:从鼠尾草植物 miltiorrhiza 和 Paeoniae radix.Methods 的水溶性的混合物调查 Chi-Shenextract ( CSE )的 antihepatocellular 癌效果: HepG2 房间( hepatocellular 癌房间线)的生长上的 CSE 的 Theeffect 被学习by3-( 4,5 ) -2,5-diphenyltetrazohum 溴化物 assay.Apoptosis 通过氮蒽橘子( AO )被检测并且染色的乙烯 dibromide ( EB )和 DNA 破碎试金。房间周期 ofHepG2 房间上的 CSE 的效果被染色方法的 propidium 碘化物学习。caspases-3 的激活, -8and-9 被免疫分析工具包检验。Bcl-2 家庭和 p53 的抄写是检测 byRT-PCR.Results : 我们的数据表明 CSE 强烈在导致 manner.CSE 的房间死亡被考虑是由观察 typicalapoptotic 的 apoptotic 的 dose-andtime-dependent 导致了 HepG2 房间死亡由 AO/EB 染色和 DNA 破碎试金的词法变化。 HepG2cell 死亡的正式就职被 apoptosis 的正式就职为 sub-G1 比例增加引起, Bcl-2 的 thedownregulation ,起来 Bax 和 p53 的规定,并且 caspases-3 and-9pathways.Conclusion 的激活:这些结果清楚地证明 CSE 能禁止 HepG2 房间和原因 apoptosis.Moreover 的增长, CSE 的反癌症效果与 Bcl-2 家庭小径和在 HepG2 房间的 caspases-3 and-9 的激活有关。 | Sheng HU Shi-min CHEN Xiao-kuan LI Rui QIN Zhi-nan MEI | 2007 | Acta Pharmacologica Sinica2007，28，8： | 10 |
| 14 | Chaiqin Chengqi Decoction decreases IL-6 levels in patients with acute pancreatitis显示文摘Objective:In this paper,we investigated the effect of the traditional Chinese medicine Chaiqin Chengqi Decoction(CQCQD) on serum cytokines in acute pancreatitis(AP) patients.Methods:Peripheral blood samples from 107 AP patients were collected within the first 48 h of AP onset and on the 10th day of CQCQD treatment.Control samples were collected from 20 healthy individuals.Serum proinflammatory cytokines tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6),and anti-inflammatory cytokines IL-10 and IL-1β receptor antagonist(IL-1ra) were examined using the Luminex 100 system.Results:Within the first 48 h of AP onset,IL-6 and IL-1ra levels in severe AP(SAP) patients were significantly higher than those in mild AP(MAP) patients,but IL-10 levels in SAP patients were significantly lower than those in MAP patients.Proinflammatory cytokine IL-6 was significantly decreased after CQCQD treatment(P<0.05),especially in SAP patients(n=25 of 36,P<0.05).The hospitalization time of SAP patients was shortened significantly when serum IL-6 decreased after CQCQD treatment(P<0.05).Conclusions:CQCQD decreased proinflammatory cytokine IL-6 levels in AP patients. | Ling WANG Yuan LI Qin MA Yong LIU Yuan-yi RUI Ping XUE Zong-guang ZHOU | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，12： | 9 |
| 15 | A new panaxadiol from the acid hydrolysate of Panax ginseng显示文摘新 panaxadiol (化合物 1 ) 从人参属人参 C. 迈耶·阿(Araliaceae ) 的全部的人参皂甙的酸 hydrolysate 被获得。根据分光镜的数据和单个水晶的 X 光检查衍射数据,它的化学结构被阐明是马树脂 --(E)-20(22)-ene-3β,12β,25-triol。 | Li Na Tao Qin Meng Jian Yuan Yin Rui Xing Hao Ran Guo | 2009 | Chinese Chemical Letters2009，20，6： | 7 |
| 16 | The molecular characterization of maize B chromosome specific AFLPs显示文摘The origin and evolution of B chromosomes could be explained by the specific DNA sequence on them. But the specific sequences known were quite limited. To investigate maize B chromosome sqicific DNA sequeces, maize genomes with and without B chromosomes were analyzed by AFLP. Only 5 markers were found specific to genomes with B chromosomes among about 2000 AFLP markers. Southern hybridization and sequence analysis revealed that only the sequence of M8-2D was a B chromosome specific sequence. This sequence contained the telomeric repeat unit AGGGTTT conserved in plant chromosome telomeres. In addition, the sequence of M8-2D shared low homology to clones from maize chromosome 4 centromere as well. M8-2D were localized to B chromosome centrorneric and telomeric regions. | ZHONG XIA QI, Hui ZENG, Xiu LAN LI, CHENG BIN CHEN, WEN QIN SONG, RUI YANG CHEN The College of Life Sciences, Nankai University, Tianjin 300071, China | 2002 | Cell Research2002，12，1： | 7 |
| 17 | IL-6 and INF-γ levels in patients with brucellosis in severe epidemic region,Xinjiang,China显示文摘Background:The incidence of brucellosis,which is caused by the Brucella species of bacteria,is rapidly rising worldwide;however,few studies have investigated the immune response to this pathogen and clinical biochemical features.In this paper,we examined the levels of various cytokines and inflammatory factors as well as clinical course characteristics in patients with brucellosis,in order to provide evidence for the diagnosis,assessment,and prognosis of this infectious disease.Methods:A total of 191 brucellosis inpatients(50 acute cases and 141 chronic cases),as well as 60 healthy control subjects,were included in the analysis.We investigated changes in the levels of six cytokines(IL-4,IL-6,IL-10,IL-17,TNF-α,INF-γ)and related clinical biochemical markers in patients with acute and chronic brucellosis in Xinjiang,China.Possible factors were statistically analyzed using the t test,χ2 test,z test and a multivariate logistic stepwise regression test.Results:We found that IL-4,IL-6,IL-10,IL-17,IFN-γ,and TNF-αlevels were higher in those with brucellosis than in controls(P<0.05).With regard to disease progression,procalcitonin(PCT)and C-reactive protein(CRP)levels were significantly higher in those with an acute infection compared to chronic cases(P<0.05).We found that the expression of all six cytokines tested was closely related to the degree of brucellosis using univariate logistic regression;however,only IL-6 and INF-γlevels were independent factors associated with the severity of brucellosis.Conclusions:Assessing cytokine levels in patients with acute and chronic brucellosis is not only useful for detecting the immune response,but can also be indicative of the severity of brucellosis.In particular,we propose IL-6 and INF-γlevels may be useful independent predictive factors in the clinical evaluation and diagnosis of brucellosis. | Zhi-Qiang Lin Guo-Yue Lin Wen-Wen He Chi Zhang Rui Zhang Yuan-Da Li Fan Wang Ying Qin Li Duan Dou-Dou Zhao Xiao-Juan Qu Hui Gao Hai Jiang | 2020 | Infectious Diseases of Poverty2020，9，3： | 7 |
| 18 | Risk factors for gastric cancer:a large-scale,population-based case-control study显示文摘Background:Early detection of gastric cancer(GC)has been the topic of major efforts in China.This study aimed to explore the risk factors associated with GC and to provide evidence for the selection of a high-risk population of GC.Methods:Based on the cancer screening cohort of the National Cancer Screening Program in Urban China,GC patients diagnosed by endoscopy and pathological examinations constituted the case group,and controls were 1:3 matched by sex and age(±5 years)individually.The variables were selected by univariable analysis of factors such as body mass index(BMI),dietary habits,lifestyle,stomach disease history,and family history of GC;and multivariable logistic regression was used to analyze the influencing factors of GC and to calculate the odds ratio(OR)of related factors and its 95%confidence interval(CI).Results:A total of 215 GC cases and 645 matched healthy controls were included in the final analysis,with a median age of 61 years for the case and control groups.Overall analysis showed that high educational level(above primary school)(OR=0.362,95%CI=0.219–0.599,P<0.001),overweight/obesity(BMI≥24 kg/m2;OR=0.489,95%CI=0.329–0.726,P<0.001),cigarette smoking(OR=3.069,95%CI=1.700–5.540,P<0.001),alcohol consumption(OR=1.661,95%CI=1.028–2.683,P=0.038),history of stomach disease(OR=6.917,95%CI=4.594–10.416,P<0.001),and family history of GC in first-degree relatives(OR=4.291,95%CI=1.661–11.084,P=0.003)were significantly correlated with the occurrence of GC.Subgroup analyses by age and gender indicated that GC risk was still increased in the presence of a history of stomach disease.A history of chronic gastritis,gastric ulcer,or gastric polyposis was positively associated with GC,with adjusted ORs of 4.155(95%CI=2.711–6.368),1.839(95%CI=1.028–3.288),and 2.752(95%CI=1.197–6.326).Conclusions:Subjects who smoke,drink,with history of stomach disease and family history of GC in first-degree relatives are the high-risk populations for GC.Therefore,attention should be paid to these subjects for GC screening. | Rui Zhang He Li Ni Li Ju-Fang Shi Jiang Li Hong-Da Chen Yi-Wen Yu Chao Qin Jian-Song Ren Wan-Qing Chen Jie He | 2021 | Chinese Medical Journal2021，，16： | 7 |
| 19 | Nutrient fluxes induced by disturbance in Meiliang Bay of Lake Taihu显示文摘A wave flume experiment was conducted to study nutrient fluxes at water-sediment interface of Meiliang Bay under different hydrodynamic conditions. The results reveal that hydrodynamics has remarkable effects on nutrient fluxes in this area. With a bottom wave stress of 0.019 N m-2 (equivalent to disturbance caused by wind SE 5-7 m s-1 at the sediment sample site of Meiliang Bay), the fluxes of TN, TDN and NH4+-N were separately 1.92× 10-3, -1.81 × 10-4 and 5.28× 10-4 mg m-2 s-1(positive for upward and negative for downward), but for TP, TDP and SRP, the fluxes were 5.69 × 10-4, 1.68 × 10-4 and -1.29 × 10-4 mgm-2 s-1. In order to calculate the released amount of nutrients based on these results, statistic analysis on the long-term meteorological data was conducted.The result shows that the maximum lasting time for wind SE 5-7 m s-1 in this area is about 15 h in summer. Further calculation shows that 111 t TN, 32 t NH4+-N, 34 t TP and 10 t TDP can be released into water (the sediment area was 47.45% of the whole surface area), resulting in concentration increase of 0.025, 0.007, 0.007 and 0.002 mg L-1 separately. With stronger disturbance (bottom wave stress is 0.217 N m-2 which is equivalent to disturbance caused by wind SE 10-11 m s-1 at the same site), there has been significant increase of nutrient fluxes (1.16× 10-2, 6.76×10-3, 1.14× 10-2 and 2.14× 10-3 mgm-2 s-1 for TN, DTN and NH4+-N and TP). The exceptions were TDP with flux having a decrease (measured to be 9.54× 10-5 mgm-2 s-1 ) and SRP with flux having a small increase (measured to be 5.42 × 10-5 mgm-2 s-1). The same statistic analysis on meteorological data reveal that the maximum lasting time for wind SE 10-11 m s-1 is no more than 5 h. Based on the nutrient fluxes and the wind lasting-time, similar calculations were also made suggesting that 232 t TN, 134.9 t TDN, 228 t NH4+-N, 42.7 t TP, 2.0 t TDP and 1.1 t SRP will be released from sediment at this hydrodynamic condition resulting in the concentration increases of 0.050, 0.029, 0.049, 0.009, 0.0004 and 0.0002 mg L-1. Therefore in shallow lakes, surface disturbance can lead to significant increase of nutrient concentrations although some components in water column had negative flux with weak disturbance (e.g. TDN and SRP in this experiment). In this case, sediment looks to be a source of nutrients. These nutrients deposited in sediment can be carried or released into water with sediment resuspension or changes of environmental conditions at water-sediment interface, which can have great effects on aquatic ecosystem and is also the characteristics of shallow lakes. | LUO Liancong, QIN Boqiang, ZHU Guangwei, SUN Xiaojing, HONG Dalin, GAO Yajun & XIE Rui Nanjing Institute of Geography & Limnology, Chinese Academy of Sciences, Nanjing 210008, China Nanjing Hydraulic Research Institute, Ministry of Water Resources, Nanjing 210024, China | 2006 | Science China Earth Sciences2006，49，z1： | 7 |
| 20 | Endogenous level of TIGAR in brain is associated with vulnerability of neurons to ischemic injury显示文摘In previous studies,we showed that TP53-induced glycolysis and apoptosis regulator(TIGAR) protects neurons against ischemic brain injury.In the present study,we investigated the developmental changes of TIGAR level in mouse brain and the correlation of TIGAR expression with the vulnerability of neurons to ischemic injury.We found that the TIGAR level was high in the embryonic stage,dropped at birth,partially recovered in the early postnatal period,and then continued to decline to a lower level in early adult and aged mice.The TIGAR expression was higher after ischemia/reperfusion in mouse brain 8and 12 weeks after birth.Four-week-old mice had smaller infarct volumes,lower neurological scores,and lower mortality rates after ischemia than 8- and12-week-old mice.TIGAR expression also increased in response to oxygen glucose deprivation(OGD)/reoxygenation insult or H_2O_2 treatment in cultured primary neurons from different embryonic stages(E16 and E20).The neurons cultured from the early embryonic period had a greater resistance to OGD and oxidative insult.Higher TIGAR levels correlated with higher pentose phosphate pathway activity and less oxidative stress.Older mice and more mature neurons had more severe DNA and mitochondrial damage than younger mice and less mature neurons in response to ischemia/reperfusion or OGD/reoxygenation insult.Supplementation of cultured neurons with nicotinamide adenine dinuclectide phosphate(NADPH) significantly reduced ischemic injury.These results suggest that TIGAR expression changes during development and its expression level may be correlated with the vulnerability of neurons to ischemic injury. | Lijuan Cao Jieyu Chen Mei Li Yuan-Yuan Qin Meiling Sun Rui Sheng Feng Han Guanghui Wang Zheng-Hong Qin | 2015 | Neuroscience Bulletin2015，31，5： | 6 |
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