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| 1 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 2 | Late Cretaceous biota and the Cretaceous-Paleogene(K--Pg)Boundary in Jiayin of Heilongjiang,China显示文摘An international cooperative study of the Late Cretaceous biota and non-marine strata including the Cretaceous-Paleogene(K--Pg) boundary in Jiayin near the Heilongjiang River,China during 2002-2010,is summarized in this paper. The strata includes the Upper Cretaceous Yong'ancun-,Taipinglinchang-,Yuliang-zi-,and Furao formations,and the Paleocence Wuyun Formation consisting of Baoshantou Member and a Coalbearing Member. Seven palynological assemblages from Santonian to Paleocene are recognized,which is used for definition of the K--Pg boundary. Through the palynological analysis of three drilled boreholes (XHY-2005,2006,2008) in Xiaoheyan of western Jiayin,the K--Pg boundary is defined within 20. 00-20. 05 m in the borehole XHY-2006 (as a standard boundary) which is just between the top of Furao Formation (late Maasterichtian) and the base of Baishantou Member (early Danian) . These new research results are supported by paleo- magnetic,geochemical and other analyses,also. On the other hand,the presence of eight taxa of Maasterichtian dinosaurs (mostly hadrosaurids) have been recognized by the authors; and two mega-plant assemblages from the Yong'ancun Fm (Santonian) to Taipinglinchang Fm (Campanian) are confirmed. These research a-chievements indicate that the Upper Cretaceous-Paleocene in Jiayin can be well correlated to the strata in the neighboring Zeya-Bureja basin,Russia. The K--Pg boundary definited in Jiayin is the first well documented non-marine K--Pg boundary in China. Also the related paleoclimate,paleoenvironment and the mass extinctions in this area during the Cretaceous-Paleocene transition are also discussed. | Sun G. Akhmetiev M. Markevich V. Ashraf A. R. Bugdaeva E. Godefroit P. Bolotsky Yu. Dong Z. M. Golovneva L. Yang H. X. Sun C. L. Sun Y. W. Quan C. Kodrul T. Kezina T. Johnson K. Nishida H Dilcher D. L. Harding I. Chen Y. J. | 2011 | Global Geology2011，14，3： | 9 |
| 3 | Nighttime sap flow of Acacia mangium and its implications for nighttime transpiration and stem water storage显示文摘Aims Nighttime sap flow of trees may indicate transpiration and/or recharge of stem water storage at night.This paper deals with the water use of Acacia mangium at night in the hilly lands of subtropical South China.Our primary goal was to reveal and understand the nature of nighttime sap flow and its functional significance.Methods Granier’s thermal dissipation method was used to determine the nighttime sap flux of A.mangium.Gas exchange system was used to estimate nighttime leaf transpiration and stomatal conductance of studied trees.Important Findings Nighttimesap flowwas substantial and showed seasonal variation similar to the patterns of daytime sap flowin A.mangium.Mean nighttime sap flow was higher in the less precipitation year of 2004(1122.4 mm)than in the more precipitation year of 2005(1342.5 mm)since more daytime transpiration and low soil water availability in the relatively dry 2004 can be the cause of more nighttime sap flow.Although vapor pressure deficit and air temperature were significantly correlated with nighttime sap flow,they could only explain a small fraction of the variance in nighttime sap flow.The total accumulated water loss(E_(L))by transpiration of canopy leaves was only;2.6–8.5%of the total nighttime sap flow(E_(t))during the nights of July 17–18 and 18–19,2006.Therefore,it is likely that the nighttime sap flow was mainly used for refillingwater in the trunk.The stem diameter at breast height,basal area and sapwood area explained much more variance of nighttime water recharge than environmental factors and other tree form features,such as tree height,stem length below the branch,and canopy size.The contribution of nighttime water recharge to the total transpiration ranged from 14.7 to 30.3%depending on different DBH class and was considerably higher in the dry season compared to the wet season. | Hua Wang Ping Zhao Dirk Hölscher Quan Wang Ping Lu Xi A.Cai Xiao P.Zeng | 2012 | Journal of Plant Ecology2012，5，3： | 5 |
| 4 | Study on scaling of mechanically alloyed and hot pressed NbCr2 Laves phase at 1 200 ℃ in air显示文摘 | ZHENG H Z LU S Q SU Q QUAN F J | 2008 | Int J Refr Metals Hard Mater2008，26，1： | 1 |
| 5 | 显示文摘 | Ni H L Zhang J S | 2001 | Polym Mat Sci Engin2001，17，5： | 1 |
| 6 | Signal amplification via cation exchange reaction:an example in the ratiometric fluorescence probe for ultrasensitive and selective sensing of Cu(Ⅱ)显示文摘 | Liu M Zhao H M Quan X | 2010 | Chem Commun2010，46，： | 1 |
| 7 | Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC显示文摘 | QUAN C REN Y Q XIANG L H | 2010 | Nat Genet2010，42，7： | 1 |
| 8 | Optimal linear cooperation for spectrum sensing in cognitive radio networks 显示文摘 | QUAN Z CUI SH G SAYED A H | 2008 | IEEE Selected in Signal Processing2008，2，1： | 1 |
| 9 | Improved chilling tolerance by transformation with betA gene for the enhancement of glycinebetaine synthesis in maize显示文摘 | Quan R D Shang M Zhang H | 2004 | Plant Science2004，166，1： | 1 |
| 10 | Role of wide contacts in the ac response of a double-barrier structure显示文摘 | QUAN J YU Y B TANG Y H | 2006 | Phys Rev B2006，73，19： | 1 |
| 11 | Transcriptional regulation ofethylene response factor LeERF2 in the expression of ethylenebiosynthesis genes controls ethylene production in tomato andtobacco 显示文摘 | Zhang Z Zhang H Quan R | 2009 | Plant Physiol2009，150，1： | 1 |
| 12 | Improved chilling tolerance by transformation with betA gene for the enhancement of glycinebetaine synthesis in maize显示文摘 | QUAN R SHANG M ZHANG H | | 0，，： | 1 |
| 13 | 查看详情显示文摘 | Quan H T Song Z Liu X F Zanardi P Sun C P | | 0，，： | 1 |
| 14 | Investigation into chromia-based catalyst and its application in preparing difluoromethane显示文摘 | Quan H D Tamura M Matsukawa Y | 2004 | J Mol Catal A2004，219，： | 1 |
| 15 | Optimal linear cooperation for spectrum sensing in cognitive radio networks显示文摘 | QUAN Zhi CUI Shuguang Saye D A H | 2008 | IEEE Journal on Selected Topics in Signal Processing2008，2，1： | 1 |
| 16 | Enhancement of 2,4-dichlorophenol degradation in conventional activated sludge systems bioaugmented with mixed special culture显示文摘 | Quan X C Shi H C Liu H | 2004 | Water Research2004，38，： | 1 |
| 17 | Decay of loschmidt echo enhanced by quantum criticality 显示文摘 | QUAN H SONG T Z LIU X F | 2006 | Phys Rev Lett2006，96，14： | 1 |
| 18 | Sorption of perfluorooctane sulfonate (PFOS) on oil and oil-derived black carbon, influence of solution pH and 显示文摘 | Chen H Chen S Quan X Zhao YZ Zhao HM | 2009 | Chemosphere2009，77，10： | 1 |
| 19 | 查看详情显示文摘 | Xie G H Zhang Z S Xue Q Zhang S M Zhao L Luo Y Chen E Quan B F Zhao Y Liu S Y | | 0，，： | 1 |
| 20 | 显示文摘 | Zhang H M Quan X Chen S | 2006 | Environ Sci Technol2006，40，： | 1 |
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