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| 1 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | Comparative evaluation of megadose methylprednisolone with dexamethasone for treatment of primary optic neuritis 显示文摘 | Menon V Mehrotra A Saxena R | 2007 | Indian J Opthalmol2007，55，5： | 1 |
| 3 | Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions显示文摘 | Mehrotra R Gupta A Singh M | 2006 | Mol Cancer2006，5，： | 1 |
| 4 | Risks of chro- nic metabolic acidosis in patients with chronic kidney disease 显示文摘 | Kopple J D Kalantar-Zadeh K Mehrotra R | 2005 | Kidney Int: Suppl2005，，： | 1 |
| 5 | Gabor filter-based edge detection 显示文摘 | Mehrotra R | 1992 | Patten Recognition1992，25，12： | 1 |
| 6 | Texture evlotion of five wrought magnesium alloys during route A equal channel angular extrusion: Experiments and simulations显示文摘 | Angew S R Mehrotra P Lillo T M | 2005 | Acta Materialia2005，53，： | 1 |
| 7 | Similar outcomes with hemodialysis and peritoneal dialysis in patients with end-stage re- nal disease 显示文摘 | Mehrotra R Chiu YW Kalantar-Zadeh K | 2011 | Arch Intern Med2011，171，2： | 1 |
| 8 | Exciting new advances in oral cancer diagnosis: avenues to early detection显示文摘 | Mehrotra R Gupta DK | 2011 | Head Neck Oncol2011，3，： | 1 |
| 9 | Anticellular and im-munosuppressive properties of ethanolic extract of Acorus cala-mus rhizome显示文摘 | Mehrotra S Mishra K P Maurya R | 2003 | Int Immunopharmacol2003，3，1： | 1 |
| 10 | Disordered mineral metabolism and vascular calcification in nondialyzed chronic kidney disease patients显示文摘 | Mehrotra R | 2006 | J Ren Nutr2006，16，2： | 1 |
| 11 | Low levels of p53 protein and chromatin silencing of p53 target genes repress apoptosis in Drosophila endocycling cells显示文摘 | Zhang B Mehrotra S Ng W L Calvi B R | 2014 | PLoS Genet2014，10，10： | 1 |
| 12 | Determinants of coronary artery caleification in diabetics with and without nephropathy 显示文摘 | Mehrotra R Budoff M Christenson P | 2004 | Kidney Int2004，66，5： | 1 |
| 13 | Serum and dialysate potassium concentrations and survival in hemodialysis patients显示文摘 | Kovesdy CP Regidor DL Mehrotra R et at | 2007 | Clin J Am Soc Nephrol2007，2，5： | 1 |
| 14 | Cognitive impairment but preservation of sexual dimorphism in cognitive abilities in chronic schizophrenia 显示文摘 | Halari R Mehrotra R Sharma T | 2006 | Psychiatry Res2006，141，2： | 1 |
| 15 | Limited-conversion technique:a safe and viable alternative to conversion in laparoscopic ventral/incisional hernia repair显示文摘 | Sharma A Mehrotra M Khullar R | 2008 | Hernia2008，12，4： | 1 |
| 16 | Rank university websites using fuzzy AHP and fuzzy TOPSIS approach on usability显示文摘 | NAGPAL R MEHROTRA D BHATIA P K | 2015 | International journal of information engineering and electronic business2015，，1： | 1 |
| 17 | A Jerk Model for Tracking Highly Maneuvering Targets显示文摘 | Kishore Mehrotra Pravas R Mahapatra | 1997 | IEEE Transactions on Aerospace and Electronics Systems1997，33，4： | 1 |
| 18 | Limited-conversion technique: a safe and viable alternative to conversion in laparo- scopie ventral/ineisional hernia repair 显示文摘 | Sharma A Mehrotra M Khullar R | 2008 | Hernia2008，12，4： | 1 |
| 19 | Effect of intermediate principal stress on strength of anisotropic rock mass 显示文摘 | SINGH B GOEL R K MEHROTRA V K | 1998 | Tunnelling and Under-ground Space Technology1998，13，1： | 1 |
| 20 | Random control trial of dermis-fat graft and interposition of temporalis fascia in the management of temporomandibular ankylosis in children 显示文摘 | Mehrotra D Pradhan R Mohammad S | 2008 | Brit J Oral Macitlofac Surg2008，46，： | 1 |
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