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| 1 | Serum leptin levels and insulin resistance are associated with gallstone disease in overweight subjects显示文摘AIM: To establish an association between the serum leptin levels and the development of gallstone disease (GD).METHODS: We carried out a non-matched case-controlled study in a university hospital in Mexico City. Two hundred and eighty-seven subjects were included: 97 cases with gallstones and 190 controls. Body mass index (BMI), fasting plasma leptin, insulin, serum lipid, and lipoprotein levels were measured. Insulin resistance was calculated by homeostasis model assessment (HOMA-IR). Unconditional logistic regression analysis (univariate and multivariate)stratified by BMI was used to calculate the risk of GD.RESULTS: The multivariate conditional regression analysis revealed a model for those patients with BMI <30. The selected variables in the model were HOMA-IR index with OR = 1.31, P= 0.02 and leptin higher than median with OR = 2.11, P= 0.05. In the stratum of BMI ≥30, we did not find a useful model.CONCLUSION: We concluded that insulin resistance and the development of GD appears to be associated with serum leptin levels in subjects with overweight, but not in obese subjects with similar metabolic profiles. | Nahum Méndez-Sánchez Luisa B Bermejo-Martínez Yolanda Vi(n|~)als Norberto C Chavez-Tapia Irina Vander Graff Guadalupe Ponciano-Rodríguez Martha H Ramos Misael Uribe | 2005 | World Journal of Gastroenterology2005，11，39： | 11 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Antihypertensive activity of milk fermented by Enterococcus faecalis strains isolated from raw milk显示文摘 | MUGUERZA B RAMOS M SANCHEZ E | 2006 | International Dairy Journal2006，16，： | 1 |
| 4 | Mechanical properties of short flax fibre bundle/polypropylene composites:Influence of matrix/fibre modification,fibre content,water uptake and recycling显示文摘 | Arbelaiz A Fernández B Ramos J A | 2005 | Composites Science and Technology2005，65，10： | 1 |
| 5 | Characteristics of the heterotrophic population in hypersaline environments of different salt concentration显示文摘 | RODRIGUEZ V F RUIZ B F RAMOS C A | 1981 | Microbiol Ecol1981，7，： | 1 |
| 6 | Copper isotope ratios in magmatic and hydrothermal ore-forming environments显示文摘 | Peter B Larson Kierran Maher Frank C Ramos Zhaoshan Chang Miguel Gaspar Lawrence D Meinert | 2003 | Chemical Geology2003，，3： | 1 |
| 7 | Sperm DNA fragmentation in infertile men with genitourinary infection by Chlamydia trachomatis and Mycoplasma显示文摘 | Gallegos G Ramos B Santiso R | 2008 | Fertil Steril2008，90，2： | 1 |
| 8 | European pen- nyroyal (Mentha pulegium) from Portugal:Chemical composi- tion of essential oil and antioxidant and antimicrobial proper- ties of extracts and essential oil显示文摘 | TEIXEIRA B MARQUES A RAMOS C | 2011 | Industrial Crops and Prod- ucts2011，36，： | 1 |
| 9 | Effect of transgenic overexpression of NR2B on NMDA receptor function and synaptic plasticity in visual cortex显示文摘 | Weisberg M P Ramos M S | 2001 | Neuropharmacology2001，41，6： | 1 |
| 10 | Scheimpflug - based tomography and biomechanical assessment in pressure - induced stromal keratopathy 显示文摘 | Faria - Correia F Ramos I Valbon B | 2013 | J Refract Surg2013，29，5： | 1 |
| 11 | Cleaning aluminum fluoride coatings from plasma reactor walls in SiCl4/Cl2 plasmas 显示文摘 | Ramos R Cunge G Pelissier B | 2007 | Plasma Sources Sci Technol2007，16，： | 1 |
| 12 | Assessing heavy metal contamination in Sado Estuary sediment:an index analysis approach 显示文摘 | Caeiro S Costa M H Ramos T B et cd | 2005 | Ecological Indicators2005，，5： | 1 |
| 13 | Genetic polymor- phisms of EPHX1, Gsk3beta, TNFSF8 and myeloma cell DKK-1 expression linked to bone disease in myeloma 显示文摘 | Durie B G Van Ness B Ramos C | 2009 | Leukemia2009，23，10： | 1 |
| 14 | The bigi- nelli reaction with an imidazolium-tagged recyclable iron catalyst : Kinetics, mechanism, and antitumoral activity显示文摘 | Ramos L M Guido B C Nobrega C C | 2013 | Chemistry A European Journal2013，19，13： | 1 |
| 15 | Char- acterization and dehydrogenation activity of Pt/Nb2 05 catalysts显示文摘 | Aranda D A G Ramos A L D Passos F B | 1996 | Catalysis Today1996，28，12： | 1 |
| 16 | Useful approximations for converted-wave AVO 显示文摘 | Ramos A C B Castagna J P | 2001 | Geophysics2001，66，6： | 1 |
| 17 | Mutual in fluence of Cu and a cationic herbicide on their adsorption desorp tion processes on two selected soils显示文摘 | Undabeytia T Morillo E Ramos A B Maqueda C | 2002 | Water Air and Soil Pollution2002，137，14： | 1 |
| 18 | Hake proteins edible films incorporated with essential oils:Physical,mechanical,antioxidant and antibacterial properties显示文摘 | Pires C Ramos C Teixera B | | 0，，01： | 1 |
| 19 | Genetic polymorphisms of EPHX1, Gsk3beta, TNFSF8 and myeloma cell DKK- 1 expression linked to bone disease in myeloma 显示文摘 | Durie BG Van Ness B Ramos C | 2009 | Leukemia2009，23，10： | 1 |
| 20 | Lipid-rich carcinoma of breast, a clincopathologic anglysis of 13 examples显示文摘 | Ramos C V Taylor H B | 1974 | Cancer1974，33，3： | 1 |
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