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| 1 | Multiparametric analysis of colorectal cancer immune responses显示文摘Colorectal cancer(CRC) is a heterogeneous disease, with a diverse and plastic immune cell infiltrate. These immune cells play an important role in regulating tumour growth-progression or elimination. Some populations of cells have a strong correlation with disease-free survival, making them useful prognostic markers. In particular, the infiltrate of CD3^+ and CD8^+ T cells into CRC tumours has been validated worldwide as a valuable indicator of patient prognosis. However, the heterogeneity of the immune response, both between patients with tumours of different molecular subtypes, and within the tumour itself, necessitates the use of multiparametric analysis in the investigation of tumour-specific immune responses. This review will outline the multiparametric analysis techniques that have been developed and applied to studying the role of immune cells in the tumour, with a focus on colorectal cancer. Because much of the data in this disease relates to T cell subsets and heterogeneity, we have used T cell populations as examples throughout. Flow and mass cytometry give a detailed representation of the cells within the tumour in a single-cell suspension on a per-cell basis. Imaging technologies, such as imaging mass cytometry, are used to investigate increasing numbers of markers whilst retaining the spatial and structural information of the tumour section and the infiltrating immune cells. Together, the analyses of multiple immune parameters can provide valuable information to guide clinical decision-making in CRC. | Julia KH Leman Sarah K Sandford Janet L Rhodes Roslyn A Kemp | 2018 | World Journal of Gastroenterology2018，24，27： | 12 |
| 2 | Nonalcoholic steatohepatitis severity is defined by a failure in compensatory antioxidant capacity in the setting of mitochondrial dysfunction显示文摘AIM To comprehensively evaluate mitochondrial(dys) function in preclinical models of nonalcoholic steatohepatitis(NASH).METHODS We utilized two readily available mouse models of nonalcoholic fatty liver disease(NAFLD) with or without progressive fibrosis: Lep^(ob)/Lep^(ob)(ob/ob) and FATZO mice on high trans-fat, high fructose and high cholesterol(AMLN) diet. Presence of NASH was assessed using immunohistochemical and pathological techniques, and gene expression profiling. Morphological features of mitochondria were assessed via transmission electron microscopy and immunofluorescence, and function was assessed by measuring oxidative capacity in primary hepatocytes, and respiratory control and proton leak in isolated mitochondria. Oxidative stress was measured by assessing activity and/or expression levels of Nrf1, Sod1, Sod2, catalase and 8-OHdG. RESULTS When challenged with AMLN diet for 12 wk, ob/ob and FATZO mice developed steatohepatitis in the presence of obesity and hyperinsulinemia. NASH development was associated with hepatic mitochondrial abnormalities, similar to those previously observed in humans, including mitochondrial accumulation and increased proton leak. AMLN diet also resulted in increased numbers of fragmented mitochondria in both strains of mice. Despite similar mitochondrial phenotypes, we found that ob/ob mice developed more advanced hepatic fibrosis. Activity of superoxide dismutase(SOD) was increased in ob/ob AMLN mice, whereas FATZO mice displayed increased catalase activity, irrespective of diet. Furthermore, 8-OHd G, a marker of oxidative DNA damage, was significantly increased in ob/ob AMLN mice compared to FATZO AMLN mice. Therefore, antioxidant capacity reflected as the ratio of catalase:SOD activity was similar between FATZO and C57 BL6 J control mice, but significantly perturbed in ob/ob mice. CONCLUSION Oxidative stress, and/or the capacity to compensate for increased oxidative stress, in the setting of mitochondrial dysfunction, is a key factor for development of hepatic injury and fibrosis in these mouse models. | Michelle L Boland Stephanie Oldham Brandon B Boland Sarah Will Jean-Martin Lapointe Silvia Guionaud Christopher J Rhodes James L Trevaskis | 2018 | World Journal of Gastroenterology2018，24，16： | 7 |
| 3 | DNA vaccination of infants in the presence of maternal antibody: a measles model in the primate显示文摘 | Mary Premenko-Lanier Paul A Rota Gary Rhodes David Verhoeven Dan H Barouch Nicholas W Lerche Norman L Letvin William J Bellini Michael B McChesney | 2003 | Virology2003，，1： | 2 |
| 4 | The structures of five new antifungal and hemolytic amphidinol analogs from Amphidinium carterae collected in New Zealand显示文摘 | Echigoya R Rhodes L Oshima Y | 2005 | Harmful Algae2005，，4： | 1 |
| 5 | Laparoscopic exploration of the common bile duct: lessons learnes from 129 consecutive cases显示文摘 | Rhodes M Nathanson L Orourk N | 1995 | Brit J Surg1995，82，6： | 1 |
| 6 | Predicion of incompressible flow in a labyrinth seal 显示文摘 | RHODE D L DEMKO J A TRAEGNER U K | 1986 | ASME Journal of Fluids Engineering1986，108，： | 1 |
| 7 | The Prediction andMeasurement of incompressible flow in a labyrinth seal 显示文摘 | DEMKO J A MORRISON G L RHODE D L | 1980 | ASME Journal of Engineering Gas Turbines Power1980，111，4： | 1 |
| 8 | Seasonal and habitat dependence of fleas parasitic on small mammals in Tanzania 显示文摘 | Anne L Herwig L Rhodes M | 2009 | Integrative Zool2009，4，5： | 1 |
| 9 | Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis:role of protein kinaseB显示文摘 | Li L El Kholy W Rhodes C J | 2005 | Diabetologia2005，48，： | 1 |
| 10 | Refractive optical sys- tems for irradiance redistribution of collimated radiation: their design and analysis 显示文摘 | Patrick W Rhodes David L Shealy | 1980 | Appl Opt1980，19，20： | 1 |
| 11 | Genetic structure of camouflage grouper, Epinephelus polyphekadion(Pisces:Serranidae), in the western central Pacific显示文摘 | Rhodes K L Lewis R I Chapman RW Sadovy Y | 2003 | Marine Biology2003，142，4： | 1 |
| 12 | Regulation of the follicle-stimulating hormone beta gene by the LHX3 LIM-homeodomain transcription factor显示文摘 | West B E Parker G E Savage J J Kiratipranon P Toomey K S Beach L R Colvin S C Sloop KW Rhodes S J | | 0，，： | 1 |
| 13 | Influence of land use on water quality of a diverse New England watershed 显示文摘 | Rhode A L Newton R M Pufall A A | 2001 | Environmental Science and Technology2001，35，： | 1 |
| 14 | Single gene control of anthracnose resistance in Citrullus? 显示文摘 | Love S L Rhodes B B | 1988 | cucurbit genetics cooperative report1988，11，： | 1 |
| 15 | Targeting triple-negative breast cancer cells with the histone deacetylase inhibitor panobinostat 显示文摘 | TATE C R RHODES L V SEGAR H C | 2012 | Breast Cancer Res2012，14，3： | 1 |
| 16 | Examining medication errors in a tertiary hospital显示文摘 | Maricle K Whitebead L Rhodes M | 2007 | J Nurs Care Qual2007，22，1： | 1 |
| 17 | The surface chemistry of zinc dialkydithiophophate, an antiwear additive, on oxidized iron and steel foils显示文摘 | Rhodes K L Stair P C | 1988 | Journal Vacuum Science Technology1988，6，： | 1 |
| 18 | Pathology of neonatal calf diarrhea induced by a coronavirus-like agent显示文摘 | Mebus C A Stair E L Rhodes M B | 1973 | Vet Pathol1973，10，： | 1 |
| 19 | The toxic effects of three Dinoflagellate species from the genus Karenia on invertebrate larvae and finfish 显示文摘 | Shi F McNabb P Rhodes L | 2012 | NewZealand Journal of Marine and Freshwater research2012，46，2： | 1 |
| 20 | Randomized trial of laparoscopic exploration of common bile versus posto-perative endoscopic retrograde cholangiography for common bile duct stones显示文摘 | Sussman L Cohen L | 1998 | Lancet1998，351，： | 1 |
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