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| 1 | Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/Ipr mouse model of systemic lupus erythematosus显示文摘热吃惊蛋白质 90 的提高的表示(HSP90 ) 在全身的豺狼座 erythematosus (SLE ) 的肾和浆液被发现了病人和 MRL/Mp-Fas lpr /Fas lpr (MRL/lpr ) 自体免疫的老鼠。如果 HSP90 的抑制将在 MRL/lpr 老鼠减少疾病,我们调查了。在在 vivo 的 vitro,有在 IL-6 的有免疫力刺激的显示出的减少的表示以前的 HSP90 禁止者 Geldanamycin 的 mesangial 房间的预告的处理, IL-12 和号码,我们发现当与 C57BL/6 相比鼠标和 MRL/lpr 鼠标与 HSP90 禁止者 17-DMAG 对待时, HSP90 表示在 MRL/lpr 肾被提高。与 17-DMAG 对待的 MRL/lpr 老鼠显示出减少的 proteinuria 并且减少了浆液 anti-dsDNA 抗体生产。Glomerulonephritis 和 glomerular IgG 和 C3 没被 17-DMAG 的管理显著地在 MRL/lpr 影响。17-DMAG 增加了 CD8 + T 房间,减少的双 negative T 房间,减少 CD4/CD8 比率和减少的小囊的 B 房间。这些研究建议 HSP90 可以在调整 T 房间区别和激活起一个作用并且 HSP90 抑制可以在豺狼座减少发炎。 | Samuel K Shimp III Cristen B Chafin Nicole L Regna Sarah E Hammond Molly A Read David L Caudell Marissa Nichole Rylander Christopher M Reilly | 2012 | Cellular & Molecular Immunology2012，9，3： | 3 |
| 2 | Surveillance for the detection of early lung cancer in patients with bronchial dysplasia 显示文摘 | Jeremy George P Banerjee A K Read C A | 2007 | Thorax2007，62，1： | 1 |
| 3 | The kinetics and mechanism of the oxidation of 1,4-thioxane by potassium ferrate显示文摘 | Boucher K D Mehlman S A | 1998 | Inorganica Chim Acta1998，267，1： | 1 |
| 4 | Phylogenetic relationships inthe subfamily Bovinae ( Mammalia:Artiodactyla) based on ribosomal DNA显示文摘 | WALL D A DAVIS S K READ B M | 1992 | Journal of Mammal1992，73，： | 1 |
| 5 | Baseline nutritional, assessment in advanced cancer patients receiving palliative ehenotnercpy显示文摘 | Slaviem K A Read J A Clarke SJ | 2003 | Nutr cancer2003，46，2： | 1 |
| 6 | The kinetics and mechanism of the oxidation of 1,4 Thioxane by potassium ferrate显示文摘 | Read J R Boucher K D Mehlman S A ect | 1998 | Inorganic Chim Acta1998，，267： | 1 |
| 7 | Epidemiology of trauma deaths: a reassessment显示文摘 | Sauaia A Moore FA Moore E Moser K Brennan R Read RA Pons PT | 1995 | J Trauma1995，38，2： | 1 |
| 8 | Detection and identification of procyanidins and flavonnols in wine by dual-electrode liquid chromatography-electrochemistry显示文摘 | Lunte S M Blankenship K D Read S A | 1988 | Analyst1988，113，： | 1 |
| 9 | New developments in the discovery of small molecule Hedgehog pathway antagonists显示文摘 | Tremblay M R Mcgovern K Read M A | 2010 | Curr Opin Chem Biol2010，14，3： | 1 |
| 10 | The kinetics and mechanism of the oxidation of 1,4-thioxane by potassium ferrate显示文摘 | BOUCHER K D MEHLMAN S A WATSON K J | 1998 | Inorganica Chimial Acta1998，267，1： | 1 |
| 11 | Electrochemical studies of nanocrystalline Mg2Si thin film electrodes prepared by pulsed laser deposition 显示文摘 | SONG S W STRIEBEL K A READE R P | 2003 | J Electrochem Soc2003，150，1： | 1 |
| 12 | Surveillance for the detection of early lung cancer in patients with bronchial dysplasia显示文摘 | Jeremy George Pbanerjee A K Read C A | 2007 | Thorax2007，62，1： | 1 |
| 13 | lst-principles calculations of the electronic-properties of silicon quantum wires显示文摘 | Read A J Needs R J Nash K J | 1992 | Phys Rev Lett1992，69，8： | 1 |
| 14 | The effect of altered flow regime on the frequency and duration of bankfull discharge : Murrumbidgee River, Australia显示文摘 | Page K Read A Frazier P Mount N | 2005 | River Research and Applications2005，21，： | 1 |
| 15 | Chloroquine binds in the cofactor binding site of Plasmodium falciparum lactate dehydrogenase显示文摘 | Read J A Wilkinson K W Tranter R | 1999 | J Biol Chem1999，274，10： | 1 |
| 16 | Invertebrate immunity and the limits of mechanistic immunology显示文摘 | Little T J Hultmark K Read A F | 2005 | Nature Immunol2005，，6： | 1 |
| 17 | Marek′s disease virus and industrialized agriculture显示文摘 | Atkins K E Read A F Savill N J | 2013 | Evolution2013，，67： | 1 |
| 18 | Evidence for the involvement of central 5-HT7 receptors in the micturition reflex in anaesthetized female rats显示文摘 | READ K E SANGER G J RAMAGE A G | 2003 | Br J Pharmacol2003，140，： | 1 |
| 19 | Genetic diversity of Poa annua in Weastern Oregon grass seed crops 显示文摘 | Renganayaki K Read J C Fritz A K | 2000 | Theoretical and Applied Genetics2000，，101： | 1 |
| 20 | The effectiveness of mass vaccination on Marek′s disease virus(MDV)outbreaks and detection within a broiler barn:A modeling study显示文摘 | Atkins K E Read A F Walkden-Brown S W | 2013 | Epidemics2013，5，4： | 1 |
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