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| 1 | Thermal hypersensitivity in a subset of irritable bowel syndrome patients显示文摘AIM:To characterize thermal hypersensitivity in patients with constipation-and diarrhea-predominant irritable bowel syndrome (IBS).METHODS:Thermal pain sensitivity was tested among patients with diarrhea-predominant IBS (D-IBS) and constipation-predominant IBS (C-IBS) compared to healthy subjects.A total of 42 patients (29 female and 13 male;mean age 27.0±6.4 years) with D-IBS;24 patients (16 female and eight male;mean age 32.5±8.8 years) with C-IBS;and 52 control subjects (34 female and 18 male;mean age 27.3±8.0 years) participated in the study.Thermal stimuli were delivered using a Medoc Thermal Sensory Analyzer with a 3 cm × 3 cm surface area.Heat pain threshold (HPTh) and heat pain tolerance (HPTo) were assessed on the left ventral forearm and left calf using an ascending method of limits.The Functional Bowel Disease Severity Index (FBDSI) was also obtained for all subjects.RESULTS:Controls were less sensitive than C-IBS and D-IBS (both at P < 0.001) with no differences between C-IBS and D-IBS for HPTh and HPTo.Thermal hyperalgesia was present in both groups of IBS patients relative to controls,with IBS patients reporting significantly lower pain threshold and pain tolerance at both test sites.Cluster analysis revealed the presence of subgroups of IBS patients based on thermal hyperalgesia.One cluster (17% of the sample) showed a profile of heat pain sensitivity very similar to that of healthy controls;a second cluster (47% of the sample) showed moderate heat pain sensitivity;and a third cluster (36% of the sample) showed a very high degree of thermal hyperalgesia.CONCLUSION:A subset of IBS patients had thermal hypersensitivity compared to controls,who reported significantly lower HPTh and HPTo.All IBS patients had a higher score on the FBDSI than controls.Interestingly,the subset of IBS patients with high thermal sensitivity (36%) had the highest FBDSI score compared to the other two groups of IBS patients. | QiQi Zhou Roger B Fillingim Joseph L Riley Ⅲ G Nicholas Verne | 2009 | World Journal of Gastroenterology2009，15，26： | 2 |
| 2 | Ash fusion temperatures under oxidizing conditions显示文摘 | LLOYD W G RILEY J T ZHOU S RISEN M A TIBBITTS R L | 1993 | Energy Fuels1993，7，4： | 1 |
| 3 | The Compaction Behaviour of Oxidised Silicon Powder显示文摘 | Stephen R G Riley F L | 1992 | Journal of European Ceramic Society1992，9，： | 1 |
| 4 | Changes in the volatile hydrocarbon content of Prudhoe bay crude oil treated under different simulated weathering conditions 显示文摘 | Riley R G Thomas B L Anderson J W | 1980 | Marine Environmental Research1980，4，： | 1 |
| 5 | Irrigation water requirements for Senegal river basin显示文摘 | Hargreaves L G Hargreaves G H Riley J P | 1985 | Joumal of Irrigation and Drainage Engineering-ASCE1985，111，3： | 1 |
| 6 | Long-termtreatment of ghrelin stimulates feeding,fat deposition,and alters the GH/IGF-I axis in the tilapia, Oreochro-mis mossambicus显示文摘 | RILEY L G FOX B K KAIYA H | 2005 | General and Comparative Endo-crinology2005，142，12： | 1 |
| 7 | Three-dimentional culture of porous biodegradable polymers显示文摘 | Ishaug Riley S L Crane-kruger G M Yaszemski | 1998 | Biomaterials1998，19，15： | 1 |
| 8 | Absenceof effects of short-term fasting on plasma ghrelin andbrain expression of ghrelin receptors in the tilapia,Oreochromis mossambicus 显示文摘 | RILEY L G FOX B K BREVES J P | 2008 | Zoological Science2008，25，8： | 1 |
| 9 | Effects of fasting on growth hormone,growth hormone receptor,and insulin-like growth factor-I axis in seawater-acclimated tilapia,Oreochromis mossambocus显示文摘 | Fox B K Riley L G Hirano T | 2006 | General and Comparative Endocrinology2006，148，3： | 1 |
| 10 | Microbial biohydrogenation of oleic acid to trans isomers in vitro显示文摘 | Mosley E E Powell G L Riley M B | 2002 | J Lipid Res2002，43，： | 1 |
| 11 | Effects of fasting on growth hormone/insulin-like growth factor-I axis in the tilapia,Oreochromis mossambicus显示文摘 | Uchida K Kajimura S Riley L G | 2003 | Comparative Biochemistry and Physiology2003，134，2： | 1 |
| 12 | Airborne spread of measles in a suburban elementary school显示文摘 | Riley E C Murphy G Riley R L | 1978 | Am J Epidemio1978，107，5： | 1 |
| 13 | Micromagnetic model for biaxial stress effects on magnetic properties显示文摘 | SABLIK M J RILEY L A BURKHARDT G L | 1994 | Journal of Magnetism and Magnetic Materials1994，132，13： | 1 |
| 14 | The vasculature and itsrole in the damaged and healing tendon 显示文摘 | Fenwick S A Hazleman B L Riley G P | 2002 | Arthritis Res2002，4，4： | 1 |
| 15 | Efficacy of epsilon-aminocaproic acid in children undergoing cardiac surgery 显示文摘 | WILLIAMS G D BRATTON S L RILEY E C | 1999 | J Cardiothorac Vasc Anesth1999，13，： | 1 |
| 16 | Changes in the volatile hydrocarbon content of Prudhoe Bay crude oil treated under different Simulated Weathering Conditions显示文摘 | THOMAS B L | 1980 | Marine Environmental Research1980，4，： | 1 |
| 17 | Effects of fasting hormone/insulin-like growth factor Ⅰ axis in the tilapia,Qreochromis mosssambicus显示文摘 | Uchida K Kajimura S Riley L G | 2003 | Comp Biochem Physiol Part A2003，134，： | 1 |
| 18 | Microbial biohydrogenation of oleic acid to trans isomers in vitro 显示文摘 | E E Mosley G L Powell M B Riley | 2002 | Lipid Research2002，43，： | 1 |
| 19 | Microbial biohydrogenation of oleic acid to trans isomers in vitro显示文摘 | Mosley E E Powell G L Riley M B | 2002 | Journal of Lipid Research2002，43，： | 1 |
| 20 | Hypothalamic-pituitary dysfunction associated with Moyamoya disease in children显示文摘 | Riley W J Brosnan P G | 1999 | J Pediatr Endocrinol Metab1999，12，3： | 1 |
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