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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis : a double-blind, placebo-controlled trial 显示文摘 | Gionchetti P Rizzello F Venturi A | 2000 | Gastroenterology2000，119，： | 1 |
| 3 | Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis:a double-blind,placebo-controlled trial显示文摘 | GIONCHETTI P RIZZELLO F VENTURI A | 2000 | Gastroenterology2000，119，2： | 1 |
| 4 | Manufacture and characterization of functional emmet beverages fermented by selected lactic acid bacteria显示文摘 | CODA P RIZZELLO C G TRANI A | | Food Microbiology0，28，： | 1 |
| 5 | Antifungal activity of sourdough fermented wheat germ used as an Ingredient for bread making显示文摘 | RIZZELLO C G CASSONE A CODA R | 2011 | Food Chemistry2011，127，3： | 1 |
| 6 | Long-term follow-up after laparoscopic treatment for endometriosis:multivariate analysis of predictive factors for recurrence of endometriotic lesions and pain显示文摘 | Coccia ME Rizzello F Palagiano A | 2011 | Eur J Obstet Gynecol Reprod Biol2011，157，1： | 1 |
| 7 | Impact on the composition of the faecal flora by a new probiotic preparation: preliminary data on maintenance treatment of patients with ulcerative colitis 显示文摘 | Venturi A Gionchetti P Rizzello F | 1999 | Aliment Pharmacol Ther1999，13，8： | 1 |
| 8 | Antifungal Activity of Wickerhamomyces anomalus and Lactobacillus plantarum during sourdough fermentation: identification of novel compounds and long-term effect during storage of wheat bread 显示文摘 | Coda R Cassone A Rizzello C G | 2011 | Applied and Environmental Microbiology2011，77，10： | 1 |
| 9 | Antifungal activity of sourdough fermented wheat germ used as an ingredient for bread rnaking显示文摘 | Rizzello C G Cassone A Coda R | 2011 | Food Chemistry2011，127，3： | 1 |
| 10 | Comparison of oral with rectal mesalazine in the treatment of ulcerative proctitis显示文摘 | Gionchetti P Rizzello F Venturi A | 1998 | Dis Colon Rectum1998，41，1： | 1 |
| 11 | Manufacture and characteri-zation of functional emmer beverages fermented by selected lactic acidbacteria显示文摘 | CODA R RIZZELLO CG TRANI A | 2011 | Food Microbiol’2011，28，： | 1 |
| 12 | Antifungal Activity of Wickerhamomyces anomalus and Lactobacillus plantarum during sourdough fermentation: identification of novel com- pounds and long-term effect during storage of wheat bread 显示文摘 | Coda R Cassone A Rizzello CG | 2011 | Applied and Environmental Microbiology2011，77，10： | 1 |
| 13 | Osteoprotegerin and B- type natriuretic peptide in non-ST elevation acute coronary syn- dromes:relation to coronary artery narrowing and plaques number 显示文摘 | Palazzuoli A Rizzello V Calabrb A | 2008 | Clin Claim Acta2008，391，1： | 1 |
| 14 | Impact on the composition of the faecal flora by a new probiotic preparation: preliminary data on maintenance treatment of patients with ulcerative colitis 显示文摘 | Venturi A Gionchetti P Rizzello F | 1999 | Aliment Pharmacol Ther1999，13，8： | 1 |
| 15 | Rifaximin systemic absorption in patients with ulcerative colitis显示文摘 | Rizzello F Gionchetti P Venturi A | 1998 | Eur J Clin Pharmacol1998，54，： | 1 |
| 16 | Rifaximin systemic absorption in patients with ulcerative colitis 显示文摘 | Rizzello F Gionchetti P VENTURI A | 1998 | Eur J Clin Pharmacol1998，54，1： | 1 |
| 17 | Osteoprotegerin and B--type natriuretic peptide in non--ST elevation acute coronary syndromes:relation to coronary artery narrowing and plaques number 显示文摘 | Palazzuoli A Rizzello V Calabro A | 2008 | Clin China Acta2008，391，12： | 1 |
| 18 | Use of fungal proteases and selected sourdough lactic acid bacteria for making wheat bread with an intermediate content of gluten 显示文摘 | Rizzello C G Curiel J A Nionelli L | 2014 | Food microbiology2014，37，： | 1 |
| 19 | Design and process study of Pd membrane reactors显示文摘 | TOSTI S BASILE A BETT1NALI L BORGOGNONI F GALLUCCI F RIZZELLO C | 2008 | International Journal of Hydrogen Energy2008，33，19： | 1 |
| 20 | Laparoscopic sleeve gastrec- tomy as revisionalsurgery in a vertical gastroplasty with gastrogastric fistula: a simplified technique 显示文摘 | Maselli R Rizzello M Genco A | 2011 | Surg Laparose Endosc Percutan Tech2011，21，1： | 1 |
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