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| 1 | Pandemic influenza 2009: Impact of vaccination coverage on critical illness in children, a Canada and France observational study显示文摘AIM To study the impact of vaccination critical illness due to H1N1pdm09, we compared the incidence and severity of H1N1pdm09 infection in Canada and France.METHODS We studied two national cohorts that included children with documented H1N1pdm09 infection, admitted to a pediatric intensive care unit(PICU) in Canada and in France between October 1, 2009 and January 31, 2010.RESULTS Vaccination coverage prior to admission to PICUs was higher in Canada than in France(21% vs 2% of children respectively, P < 0.001), and in both countries, vaccination coverage prior to admission of these critically ill patients was substantially lower than in the general pediatric population(P < 0.001). In Canada, 160 children(incidence = 2.6/100000 children) were hospitalized in PICU compared to 125 children(incidence = 1.1/100000) in France(P < 0.001). Mortality rates were similar in Canada and France(4.4% vs 6.5%, P = 0.45, respectively), median invasive mechanical ventilation duration and mean PICU length of stay were shorter in Canada(4 d vs 6 d, P = 0.02 and 5.7 d vs 8.2 d, P = 0.03, respectively). H1N1pdm09 vaccination prior to PICU admission was associated with a decreased risk of requiring invasive mechanical ventilation(OR = 0.30, 95%CI: 0.11-0.83, P = 0.02).CONCLUSION The critical illness due to H1N1pdm09 had a higher incidence in Canada than in France. Critically ill children were less likely to have received vaccination prior to hospitalization in comparison to general population and children vaccinated had lower risk of ventilation. | Olivier Fléchelles Olivier Brissaud Robert Fowler Thierry Ducruet Philippe Jouvet the Pediatric Canadian Critical Care Trials Group H1N1 Collaborative and Groupe Francophone de Réanimation et Urgences Pédiatriques | 2016 | World Journal of Clinical Pediatrics2016，5，4： | 2 |
| 2 | Raman spectroscopy employed for the determination of the intermediate phase in polyethylene显示文摘 | CHRISTOPHER C N ROBERT J M BERT J K et al | 1995 | Macromolecules1995，28，8： | 1 |
| 3 | Henoch schonlein purpura:areview article显示文摘 | Roberts PF Waller TA Brinker TM et aI | 2007 | South Med J2007，100，8： | 1 |
| 4 | In-terferons and the maternal-conceptus dialog in mam-mals显示文摘 | ROBERTS R M CHEN Y EZASHI T et a1 | 2008 | Semin Cell Dev Biol2008，19，： | 1 |
| 5 | Acute effect of smoking on digita laiteiy blood flow in mans显示文摘 | Sinus F William F et a | 1994 | Hand Surg1994，19，10： | 1 |
| 6 | The vascular endothelial growth factor family in adverse pregnancy outcomes显示文摘 | Andraweera PH Dekker GA Roberts CT et a/ | 2012 | Hum Reprod Update2012，18，4： | 1 |
| 7 | lnfluence of high fiber diets given to gestating sows on serum concentrations of micronutri- ents显示文摘 | Girard C L Robert S Matte J J et d | 1995 | Livestock Producion Science1995，43，： | 1 |
| 8 | CA242, a new tumor marker for pancreatic cancer a comparison with CA199, CA50 and CEA显示文摘 | Huglund C Lundin J Roberts PJ et cd | 1994 | Br J Cancer1994，70，4： | 1 |
| 9 | Cost-effectiveness of botulinum toxin type a in the treatment of post-stroke spasticity 显示文摘 | Ward A Roberts G Warner J et a/ | 2005 | JRehabil Med2005，37，4： | 1 |
| 10 | Autophagy in immune defense against Mycobacterium tuberculosis 显示文摘 | Vergne l Singh S Roberts E et aI | 2006 | Autophagy2006，2，3： | 1 |
| 11 | Spontaneous hemopneu- mothorax- results of conservative treatment显示文摘 | de Perrot M Deleaval J Robert J et al | 2000 | Swiss Surg2000，6，2： | 1 |
| 12 | Raised maternal serum inhibin A concentration at 10 to 14 weeks of gestation is associated with pre-eclampsia显示文摘 | Sebire N J Roberts L Noble P et a | 2000 | BJOG2000，107，6： | 1 |
| 13 | D- LysAsnProTyr tetrapeptide:a novel B-cell stimp Lant and stabilized bursin mimetic 显示文摘 | Lyne Gagnon Marika DiMarco Robert Kirby et a2 | 2000 | Vaccine2000，18，18： | 1 |
| 14 | Palliative use of aminocaproic acid to control upper gastrointestinal bleeding显示文摘 | Roberts SB Ooyne PJ Smith TJ et aI | 2010 | J Pain Symptom Manage2010，40，3： | 1 |
| 15 | Comparative inhibition of rodent and human erythroeytes acetylcholinesterase by carbofuran and carbaryl显示文摘 | Rao PS Roberts GH Pope CN et a1 | 1994 | PesticBiochem Physiol1994，48，： | 1 |
| 16 | Renal angiomyolipoma:growth followed up with CT and/or US显示文摘 | LEMAITRE L ROBERT R CIAUDON M et a1 | 1995 | Radiology1995，197，3： | 1 |
| 17 | Wireless power transfer via strongest couples magnetic resonances显示文摘 | Andre Kurs Aristeidis Karalis Robert Moffatt et a1 | 2007 | Science2007，，37： | 1 |
| 18 | Quantilying microbially induced deterioration of concrete:initial studies显示文摘 | ROBERTS D J NICA D ZUO G et a1 | 2002 | InterBiodeter Biodegr2002，49，： | 1 |
| 19 | Combined PI3K/ mTOR and MEK inhibition provides broad antitumor activity in faithful murine cancer models显示文摘 | Roberts PJ Usary JE Darr DB et a/ | 2012 | Clin Cancer Res2012，18，19： | 1 |
| 20 | Human C-reactive protein (CRP) 1059G/C polymorphism 显示文摘 | Cao H Robert A Hegele J et ai | 2000 | Hum Genet2000，45，2： | 1 |
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