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| 1 | Autoimmune gastritis:Pathologist's viewpoint显示文摘Western countries are seeing a constant decline in the incidence of Helicobacter pylori-associated gastritis, coupled with a rising epidemiological and clinical impact of autoimmune gastritis. This latter gastropathy is due to autoimmune aggression targeting parietal cells through a complex interaction of auto-antibodies against the parietal cell proton pump and intrinsic factor, and sensitized T cells. Given the specific target of this aggression, autoimmune gastritis is typically restricted to the gastric corpus-fundus mucosa. In advanced cases, the oxyntic epithelia are replaced by atrophic(and metaplastic) mucosa, creating the phenotypic background in which both gastric neuroendocrine tumors and(intestinal-type) adenocarcinomas may develop. Despite improvements in our understanding of the phenotypic changes or cascades occurring in this autoimmune setting, no reliable biomarkers are available for identifying patients at higher risk of developing a gastric neoplasm. The standardization of autoimmune gastritis histology reports and classifications in diagnostic practice is a prerequisite for implementing definitive secondary prevention strategies based on multidisciplinary diagnostic approaches integratingendoscopy, serology, histology and molecular profiling. | Irene Coati Matteo Fassan Fabio Farinati David Y Graham Robert M Genta Massimo Rugge | 2015 | World Journal of Gastroenterology2015，21，42： | 8 |
| 2 | miRNAs in precancerous lesions of the gastrointestinal tract显示文摘In spite of the well-established understanding of the phenotypic lesions occurring in the shift from native epithelia to invasive (adeno) carcinoma, the molecular typing of the precancerous changes in the gastrointestinal tract remains unreliable. In recent years, no biomarkers have aroused as much interest as the miRNAs,a class of non-coding RNA molecules that function as endogenous silencers of numerous target genes. Aberrant miRNA expression is a hallmark of human disease,including cancer. Unlike most mRNAs, miRNAs are both long-living in vivo and very stable in vitro . Such characteristics allow their testing in paraffin-embedded tissue samples, which is essential in the biological profiling of small (phenotypically characterized) preneoplastic lesions of the gastrointestinal tract (as well as in other fields of human pathology). The upcoming challenge lies in the reliable identification of disease-specific targets of dysregulated miRNAs, to enable miRNA testing in the clinical management of the secondary prevention of gastrointestinal cancer. | Matteo Fassan Carlo M Croce Massimo Rugge | 2011 | World Journal of Gastroenterology2011，17，48： | 7 |
| 3 | Topographic patterns of intestinal metaplasia and gastric cancer显示文摘 | Mauro Cassaro Massimo Rugge Oscar Gutierrez Gioacchino Leandro David Y Graham Robert M Genta | 2000 | The American Journal of Gastroenterology2000，，： | 2 |
| 4 | Assessing risks for gastric cancer: New tools for pathologists显示文摘Although the Sydney Systems (original and updated) for the classification of gastritis have contributed substantially to the uniformity of the reporting of gastric conditions, they lack immediacy in conveying to the user information about gastric cancer risk. In this review, we summarize the current understanding of the gastric lesions associated with an increased risk for cancer, and present the rationale for a proposal for new ways of reporting gastritis. In addition to the traditional histopathological data gathered and evaluated according to the Sydney System rules, pathologists could add an assessment expressed as grading and staging of the gastric inflammatory and atrophic lesions and integrate these findings with pertinent laboratory information on pepsinogens and gastrin levels. Such an integrated report could facilitate clinicians’ approach to the management of patients with gastric conditions. | Robert M Genta Massimo Rugge | 2006 | World Journal of Gastroenterology2006，12，35： | 2 |
| 5 | Clinical,virologic and histologic outcome following seroconversion from HBeAg to anti-HBe in chronic hepatitis type B显示文摘 | Fattovich G Rugge M Brollo L Pontisso P Noventa F Guido M Alberti A Realdi G | 1986 | Hepatology1986，6，2： | 1 |
| 6 | Gastric dysplasia : the padova international classification 显示文摘 | RUGGE M CORREA P DIXON MF | 2000 | Am J Surg Pathol2000，24，2： | 1 |
| 7 | Clinical, virologic and histologic outcome following seroconversion from HBeAg to anti-HBe in chronic hepatitis type B显示文摘 | Fattovich G Rugge M Brollo L | 1986 | Hepatology1986，6，2： | 1 |
| 8 | Gastric mucosal atrophy:interobserver consistency using new criteria for classification and grading显示文摘 | Rugge M Correa P Dixon MF | | 0，，： | 1 |
| 9 | Gastritis OLGA staging and gastric cancer risk: a twelve-year clinico- pathological follow-up study 显示文摘 | Rugge M de Boni M Pennelli G | 2010 | Aliment Pharmacol Ther2010，31，10： | 1 |
| 10 | p53 alterations but no human papillomavirus infection in preinvasive and advanced squamous esophageal cancer in Italy显示文摘 | Bovo D Busatto G | 1997 | Cancer Epidemiol Biomarkers Prev1997，6，3： | 1 |
| 11 | The phenotype of gastricmucosa coexisting with Barrett’s oesophagus显示文摘 | Rugge M Russov Busatto G Busatto G | 2001 | J Clin Pathol2001，54，6： | 1 |
| 12 | Gastric cancer risk in patients with helicobacter pylori infection and following its eradication 显示文摘 | Rugge M | 2015 | Gastroenterol Clin North Am2015，44，3： | 1 |
| 13 | Gastric mucosalatrophy: interobserver consistency using new criteria forclassification and grading 显示文摘 | RUGGE M CORREA P DIXON M F | 2002 | Aliment Pharmacol Ther2002，16，7： | 1 |
| 14 | Gastric dysplasia:the Padova international classification显示文摘 | Rugge M Correa P Dixon MF | 2000 | Am J Surg Pathol2000，24，2： | 1 |
| 15 | Gastric mucosal atrophy:interobserver consistency using new criteria for classification and grading显示文摘 | Rugge M Correa P Dixon MF | 2002 | Aliment Pharmacol Ther2002，16，7： | 1 |
| 16 | Lipoprotein-X and diagnosis of cholestasis: comparison with other biochemical parameters and liver biopsy显示文摘 | Fellin R Manzato E Zotti S Baggio G Briani G Rugge M | 1978 | Clin Chim Acta1978，85，： | 1 |
| 17 | Immunohistochemical evidence of p53 over expression in gastric epithelial dysplasia cancer显示文摘 | Rugge M Shiao Y H Correa P | 1992 | Epidemiol Biomarkers Prev1992，1，7： | 1 |
| 18 | The long term outcome of gastric non-invasive neoplasia 显示文摘 | Rugge M Cassaro M Di Mario F | 2003 | Gut2003，52，8： | 1 |
| 19 | Effect of Helicobacter pylori eradication on development of dyspeptic and reflux disease in healthy asymptomatic subject显示文摘 | VAIRA D VAKIL N RUGGE M | 2009 | Gut2009，52，11： | 1 |
| 20 | p53 alteration in gastric pre- cancerous lesions 显示文摘 | Shiao YH Rugge M Correa P | 1994 | Am J Pathol1994，144，3： | 1 |
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