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| 1 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | Characterization of flavonoids in cranberry (Vaccinium macrocarpon) powder显示文摘 | VVEDENSKAYA I O ROSEN R T GUIDO J E RUSSELL D J MILLS K A VORSA N | 2004 | Journal of Agricultural and Food Chemistry2004，52，： | 1 |
| 3 | Covergence analysis of an approximations of miscible displacement in porous media by mixed finite element and a modified method of characteristics显示文摘 | Ewing R C Russell T F Wheeler M F | 1984 | Computer Methods in Applied Mechanics and Engineering1984，47，1： | 1 |
| 4 | Antigenic and genetic characteristics of swine-origin 2009 A (HIN1) influenza viruses circulating in humans 显示文摘 | GARTEN R J DAVES C T RUSSELL C A | 2009 | Science2009，325，： | 1 |
| 5 | Cast metal composites reinforced by SiC particles显示文摘 | FLETCHER T R CORNIE J A RUSSELL K C | 1988 | Metal and Materials1988，23，9： | 1 |
| 6 | Engireering targe- ted viral vectors for gene therapy显示文摘 | WAEHLER R RUSSELL S J CURIEL D T | 2007 | Nat Rev Genet2007，8，8： | 1 |
| 7 | WHO guidelines for the management of postpartum hemorrhage and retained placenta显示文摘 | Russell R T | 2011 | Human Fertility2011，142，： | 1 |
| 8 | Appetite and growth compensation European minnows (Phoxinus phoxinus) following short periods of food restriction显示文摘 | Russell N R Wootton R T | 1992 | Environmental Biology of Fishes1992，34，： | 1 |
| 9 | Efficacy of complete decongestive therapy and manual lymphatic drainage on treatment-related lymphedema in breast cancer显示文摘 | Koul R Dufan T Russell C | 2007 | Int J Radiat Oncol Biol Phys2007，，3： | 1 |
| 10 | The current status of the FAMM thermal maturity technique for petroleum exploration in Australia 显示文摘 | Wilkins R W T Buckingham C P Sherwood N Russell N J Faiz M Kurusingal J | 1998 | Australian Petroleum Production and Exploration Association Journal1998，38，： | 1 |
| 11 | Antigenic and genetic characteristics of swine-origin 2009 A ( H1N1 ) influenza viruses circulating in humans 显示文摘 | GARTEN R J DAVIS C T RUSSELL C A | 2009 | Science2009，325，： | 1 |
| 12 | Antigenic and Genetic Characteristica of Swine Origin 2009 A (H1N1) Influence Viruses Circulating in Humans显示文摘 | GARTEN R J DAVIS C T RUSSELL C A | 2009 | Science2009，5，： | 1 |
| 13 | Pertrochanteric hip fractures: time for change 显示文摘 | Russell T A Sanders R | 2011 | J Orthop Trauma2011，25，4： | 1 |
| 14 | Convergence analysis of an approximation of miscible displacement in porous media by mixed finite elements and a modified method of character- istics显示文摘 | Ewing R E Russell T F Wheeler M F | 1984 | Computer Methods Appl Mech Engrg1984，47，12： | 1 |
| 15 | Probing the Sialie aeid binding site of hemagglutinin-neuraminidase of Newcastle disease virus: identification of key aminio acids involved in cell binding,catalysis and fusion 显示文摘 | Connaris H Takimoto T Russell R | 2002 | J Virol2002，76，4： | 1 |
| 16 | Antigenic and genetic characteristics of swine-origin 2009A(H1N1) influenza viruses circulating in humans 显示文摘 | GARTEN R J DAVES C T RUSSELL C A | 2009 | Science2009，325，5937： | 1 |
| 17 | Macromolecules 显示文摘 | Russell G T Gilbert R G Napper D H | 1992 | 25: 2459-24691992，25，： | 1 |
| 18 | The effect of sulfate-reducing bacteria on adsorption of Cs-137 by soils from arid and tropical regions显示文摘 | Russell R A Holden P J Payne T E | 2004 | Journal of Environmental Radioactivity2004，74，123： | 1 |
| 19 | Probing the sialic acid binding site of the hemagglutinin-neuram inidase of Newcastle disease virus:idetification of key amininon acids involved in cell binding,catalysis and fusion显示文摘 | CONNARIS H TAKIMOTO T RUSSELL R | 2002 | J Virol2002，76，4： | 1 |
| 20 | Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans 显示文摘 | Garten R J Davis C T Russell C A | 2009 | Science2009，325，： | 1 |
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