|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival显示文摘BACKGROUND: In a multidisciplinary conference patients with advanced non-resectable hepatocellular carcinoma (HCC) were stratified according to their clinical status and tumor extent to different regional modalities or to best supportive care. The present study evaluated all patients who were stratified to repeated transarterial chemoembolization (TACE) from 1999 until 2003 in terms of tumor response, toxicity, and survival. A moderate embolizing approach was chosen using a combination of degradable starch microspheres (DSM) and iodized oil (Lipiodol) in order to combine anti-tumoral efficiency and low toxicity. METHODS: Fourty-seven patients were followed up prospectively. TACE treatment consisted of cisplatin (50 mg/m2), doxorubicin (50 mg/m2), 450-900 mg DSM, and 5-30 ml Lipiodol. DSM and Lipiodol were administered according to tumor vascularization. Patient characteristics,toxicity, and complications were outlined. In multivariate regression analyses of pre-treatment variables from a prospective database, predictors for tumor response and survival after TACE were determined. RESULTS: 112 TACE courses were performed (2.4±1.5 courses per patient). Mean maximum tumor size was 75 (± 43) mm, in 68% there was bilobar disease. Best response to TACE treatment was: progressive disease (PD) 9%, stable disease (SD) 55%, partial remission (PR) 36%, and complete remission (CR) 0%. Multivariate regression analyses identified tumor size ≤75 mm, tumor number ≤5, and tumor hypervascularization as predictors for PR. The overall 1-, 2-, and 3-year-survival rates were 75%, 59%, and 41%, respectively, and the median survival was 26 months. Low α-fetoprotein levels (<400 ng/ml) (Odds ratio=3.3) and PR as best response to TACE (Odds ratio=6.7) were significantly associated with long term survival (>30 months, R2=36%). Grade 3 toxicity occurred in 7.1% (n=8), and grade 4 toxicity in 3.6% (n=4) of all courses in terms of reversible leukopenia and thrombocytopenia. The incidence of major complications was 5.4% (n=6). All complications were managed conservatively. The mortality within 6 weeks after TACE was 2.1% (one patient). CONCLUSIONS: DSM and Lipiodol were combined successfully in the palliative TACE treatment of advanced HCC resulting in high rates of tumor response and survival at limited toxicity. Favourable tumor response was associated with tumor extent and vascularization. TACE using DSM and Lipiodol can be considered a suitable palliative measure in patients who might not tolerate long acting embolizing agents. | Timm D Kirchhoff Joerg S Bleck Arne Dettmer Ajay Chavan Herbert Rosenthal Sonja Merkesdal Bernd Frericks Lars Zender Nisar P Malek Tim F Greten Stefan Kubicka Michael P Manns Michael Galanski | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 15 |
| 2 | Combination of repeated single-session percutaneous ethanol injection and transarterial chemoembolisation compared to repeated single-session percutaneous ethanol injection in patients with non-resectable hepatocellular carcinoma显示文摘瞄准:为病人评估经皮的乙醇注射(PEI ) 的治疗效果与先进, non-resectable HCC 与 transarterial chemoembolisation 的联合相比(不作声) 并且重复单个会议的 PEI,独自重复了单个会议的 PEI,重复不作声独自一个,或最好的支持的照顾。方法:在学习时期期间接受了 PEI 治疗的所有病人根据物理地位和肿瘤程度被包括并且成层到下列治疗形式之一:联合不作声并且重复单个会议的 PEI,独自重复了单个会议的 PEI,重复不作声独自一个,或最好的支持的照顾。包括Okuda分类,门静脉血栓的存在,腹水的存在,肿瘤的数字,最大的肿瘤直径,和假胆硷酯酶( CHE )的临床的参数的预示的价值,以及孩子呸上演, alpha-fetoprotein (法新社),发烧,复杂并发症的发生在这些组之间被估计并且比较。幸存用 Kaplan-Meier 被决定,多,变量回归分析。结果:所有病人的 1 年、 3 年的幸存是 73% 和 47% 。在亚群分析,联合不作声, PEI (1 ) 与更长的幸存被联系(1- , 3- , 5 年的幸存:90% , 52% ,和 43%) 与 PEI 治疗相比独自一个(2 )(1- , 3- , 5 年的幸存:65% , 50% ,和 37%) 。(3 ) 在起始的层化以后的第二等的 PEI 产出可比较的结果不作声(1- , 3- , 5 年的幸存:91% , 40% ,和 30%) 当在到最好的支持的照顾(4 ) 的层化以后的 PEI 与减少的幸存被联系时(1- , 3- , 5 年的幸存:50% , 23% , 12%) 。除了选择治疗形式,为更好的幸存的预言者是肿瘤数字(n <
5 ) ,肿瘤尺寸(<
5 厘米) ,在 PEI 前的没有腹水,和在 PEI 以后的稳定的假胆硷酯酶(P <
0.05 ) 。在在 PEI 以后的 2 wk 以内的死亡是 2.8%(n = 3 ) 。有 24 (8.9%) 主修在包括部分肝梗塞,焦点的肝坏死,和肝脓肿的 PEI 以后的复杂并发症。所有复杂并发症能非通过手术被管理。结论:重复单个会议的 PEI 在有以可接受、可管理的复杂并发症率的先进 HCC 的病人是有效的。病人们成层到联合不作声, PEI 能比那些独自成层到重复 PEI 期望更长的幸存。而且,有在好临床的地位的大或多重的肿瘤的病人可以也从联合获利不作声并且为第二等的 PEI 的再考虑。 | Arne Dettmer Timm D Kirchhoff Michael Gebel Lars Zender Nisar P Malek Bernhard Panning Ajay Chavan Herbert Rosenthal Stefan Kubicka Susanne Krusche Sonja Merkesdal Michael Galanski Michael P Manns Joerg S Bleck | 2006 | World Journal of Gastroenterology2006，12，23： | 14 |
| 3 | 高危患者目标血压与心血管病预后显示文摘指南推荐血压目标值应〈140/90 mmHg(1mmHg=0.133kPa)以减少心血管事件的发生。但与其他心血管病预后(如冠状动脉事件)相比,包括脑卒中及心力衰竭在内的心血管病预后与收缩压下降关系更密切。一些心血管事件(如冠状动脉事件)风险在收缩压低时亦增高,风险-收缩压关系呈J形曲线,而脑卒中与血压不是J形曲线关系。 | B?hm M Schumacher H Teo KK Lonn EM Mahfoud F Mann JF Mancia G Redon J Schmieder RE Sliwa K Weber MA Williams BYusuf S 曲浥晨 叶鹏 | 2017 | 中华高血压杂志2017，25，6： | 14 |
| 4 | Status review of mercury control options for coal-fired power plants显示文摘 | John H Pavlish Everett A Sondreal Michael D Mann Edwin S Olson Kevin C Galbreath Dennis L Laudal Steven A Benson | 2003 | Fuel Processing Technology2003，，2： | 4 |
| 5 | The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: Current management显示文摘 | A. Dignass G. Van Assche J.O. Lindsay M. Lémann J. S?derholm J.F. Colombel S. Danese A. D’Hoore M. Gassull F. Gomollón D.W. Hommes P. Michetti C. O’Morain T. ?resland A. Windsor E.F. Stange S.P.L. Travis | 2010 | Journal of Crohn’s and Colitis2010，，1： | 2 |
| 6 | Palladium-cat-alyzed C-N(sp 2)Bond formation:N-Arylation of aromatic and un-saturration nitrogen and the reductive elimination chemistry of palladi-um azolyl nd methyleneamine complexes显示文摘 | Grace Mann John F Hartwig Michael S Drive | 1998 | J Am Chem Soc1998，，： | 2 |
| 7 | Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha synuelein: Implication for alpha-synueleinopathies显示文摘 | ISHII A NONAKA T TANIGUCHI S SAOTO T ARAI T MANN D IWATSUBO T HISANAQA S GOEDERT M HASEQAWA M | 2007 | FEBS Lett2007，581，24： | 1 |
| 8 | Tissue expression and immunolocalization of tumor necrosis factor-alpha in postinfarction dysfunctional myocardium显示文摘 | Irwin MW Mak S Mann DL | 1999 | Circulation1999，99，11： | 1 |
| 9 | Axin-mediated CKI phosphorylation of beta -catenin at Set 45:a molecular switch for the Wnt pathway显示文摘 | Amit S Hatzubai A Birman Y Andersen J S Ben Shushan E Mann M | 2002 | Genes Dev2002，16，： | 1 |
| 10 | Purification and characterization of perlucin and perlustrin, two new proteins from the shell of the mollusc Haliotis laevigata显示文摘 | Weiss I M Kaufmann S Mann K | 2000 | Biochem Biophys Res Commun2000，267，： | 1 |
| 11 | Differential effects of culture on imprinted H19 expression in the preimplantation mouse embryo 显示文摘 | DOHERTY A S MANN M R TREMBLAY K D | 2000 | Biology of Reproduction2000，62，： | 1 |
| 12 | T-cell responses to human papillomavirus type 16 among women with different grades of cervical neoplasia显示文摘 | Steele JC Mann CH Rookes S | 2005 | Br J Cancer2005，93，： | 1 |
| 13 | Electrical properties of eaolian sand and silt显示文摘 | Kanagy II S P Mann C J | 1994 | Earth-science Review1994，36，： | 1 |
| 14 | Global-Scale temperature patterns and climate forcing over the past six Centuries显示文摘 | Mann M E Bradley R S Hughes M K | 1998 | Nature1998，392，： | 1 |
| 15 | Compartmental modulation of abdominal Hox expression by engrailed and sloppy-paired patterns the fly ec- toderm 显示文摘 | Gebelein B Mann R S | 2007 | Dev Biol2007，308，2： | 1 |
| 16 | Biomimetic pathways for assembling inorganic thin films显示文摘 | Aksay I A Trau M Manne S | | 0，，： | 1 |
| 17 | Beam diameter depend- ence of surface damage threshold of fused silica fibers and preforms for nanosecond laser treatment at 1 064 nm wavelength显示文摘 | Mann G Pentzien S Kruger J | 2013 | Applied Surface Science2013，276，： | 1 |
| 18 | In vitro reconstitution of the first steps of anatoxin-a biosynthesis in Oscillatoria PCC 6506: from free L-proline to acyl carrier protein bound dehydroproline显示文摘 | Mejean A Mann S Vassiliadis G | 2010 | Biochemistry2010，49，1： | 1 |
| 19 | IL - 6 promotes immune responses in human ulcerative colitis and induces a skin - homing phenotype in the dendritic cells and Tcells they stimulate 显示文摘 | D Bemardo S Vallejo - Diez ER Mann | 2012 | Eur J Inmmnol2012，42，5： | 1 |
| 20 | Measuring cancer patients' psychological distress and well-being:a factor analytic assessment of the Mental Health Inventory显示文摘 | Manne S Schnoll R | | 0，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员