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| 1 | Current status of intravenous tissue plasminogen activator dosage for acute ischaemic stroke:an updated systematic review显示文摘The optimal dose of recombinant tissue plasminogen activator(rtPA)for acute ischaemic stroke(AIS)remains controversial,especially in Asian countries.We aimed to update the evidence regarding the use of low-dose versus standard-dose rtPA.We performed a systematic literature search across MEDLINE,Embase,Cochrane Central Register of Controlled Trials(CENTRAL),PsycINFO and Cumulative Index to Nursing and Allied Health Literature(CINAHL)from inception to 22 August 2016 to identify all related studies.The outcomes were death or disability(defined by modified Rankin Scale 2-6),death,and symptomatic intracerebral haemorrhage(sICH).Where possible,data were pooled for meta-analysis with ORs and corresponding 95% CIs by means of random-effects or fixed-effects meta-analysis.We included 26 observational studies and 1 randomised controlled trial with a total of 23210 patients.Variable doses of rtPA were used for thrombolysis of AIS in Asia.Meta-analysis shows that low-dose rtPA was not associated with increased risk of death or disability(OR 1.13,95% CI 0.95 to 1.33),or death(OR 0.86,95% CI 0.74 to 1.01),or decreased risk of sICH(OR 1.06,95% CI 0.65 to 1.72).The results remained consistent when sensitivity analyses were performed including only low-dose and standard-dose rtPA or only Asian studies.Our review shows small difference between the outcomes or the risk profile in the studies using low-dose and/or standard-dose rtPA for AIS.Low-dose rtPA was not associated with lower risk of death or disability,death alone,or sICH. | Xia Wang Shoujiang You Shoichiro Sato Jie Yang Cheryl Carcel Danni Zheng Sohei Yoshimura Craig S Anderson Else Charlotte Sandset Thompson Robinson John Chalmers Vijay K Sharma | 2018 | Stroke & Vascular Neurology2018，3，1： | 10 |
| 2 | 评估清晨或夜晚服用降压药对24h动态血压的影响:清晨或夜间服用降压药的希腊英国联合研究显示文摘观察数据显示,临床血压水平与随后的主要不良心血管事件之间存在强烈的线性关系。然而,动态血压监测显示,夜间血压水平比24h或白天血压水平更能预测主要的不良心血管事件。此外,夜间与白天的血压比值和杓型状态也是心血管结局的重要独立预测因素。这些发现可能对抗高血压药物的最佳给药时间有影响,一些研究表明,夜晚服用降压药可能较白天服药减少心血管事件。 | Poulter NR Savopoulos C Anjum A Apostolopoulou M Chapman N Cross M Falaschetti E Fotiadis S James RM Kanellos I Szigeti M Thom S Sever P Thompson D Hatzitolios AI 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，10： | 7 |
| 3 | Ionotropic receptors and ion channels in ischemic neuronal death and dysfunction显示文摘到神经原的精力供应的损失在击期间导致被称为缺氧的去极的膜潜力的快速的损失。因为离子的流动的 dysregulation 和 ATP 的损失,缺氧的去极在神经原上导致巨大的生理的应力驾驶维持电气化学的坡度的离子泵。在这评论,我们在场一些被认为贡献神经原并且随后的缺氧的去极的 ionotropic 受体和离子隧道的概述,到房间死亡。为作为门 ligand 的阳离子隧道工作的 glutamate 和 ATP 的 ionotropic 受体在神经原的死亡和机能障碍是批评的。有趣地,二这些受体(P2X7 和 NMDAR ) 被显示了联合离子隧道到 pannexin-1 (Panx1 ) 。我们也讨论短暂受体潜力(TRP ) 的重要角色响应局部缺血的隧道和酸察觉到的离子隧道(ASIC ) 。从我们缺氧的去极的当前的理解出现的中央挑战是需要阐明这些离子隧道到的机械学、时间的相互关系充分在击期间在神经原上欣赏他们的影响。 | Nicholas L WEILINGER Valentyna MASLIEIEVA Jennifer BIALECKI Sarup S SRIDHARAN Peter L TANG Roger J THOMPSON | 2013 | Acta Pharmacologica Sinica2013，34，1： | 5 |
| 4 | Is Duplex Surveillance of Value After Leg Vein Bypass Grafting?: Principal Results of the Vein Graft Surveillance Randomised Trial (VGST)显示文摘 | A H. Davies A J. Hawdon M R. Sydes S G. Thompson | 2005 | Circulation2005，，： | 2 |
| 5 | Enhanced band-gap blueshift due to grow Ⅴ intermixing in InGaAsP multiple quantum well laser structures induced by low temperature grown InP显示文摘 | Lee A S W Mackenjie M Thompson D A | 2001 | Appl Phys Lett2001，78，21： | 2 |
| 6 | No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer显示文摘AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based casecontrol study of incident colon cancer individuals (n= 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene. | Lynette S Phillips Cheryl L Thompson Alona Merkulova Sarah J Plummer Thomas C Tucker Graham Case Li Li | 2009 | World Journal of Gastroenterology2009，15，30： | 2 |
| 7 | Simulation of transpiration, drainage, N uptake, nitrate leaching, and N uptake concentration in tomato grown in open substrate显示文摘 | M. Gallardo R.B. Thompson J.S. Rodríguez F. Rodríguez M.D. Fernández J.A. Sánchez J.J. Magán | 2009 | Agricultural Water Management2009，，12： | 2 |
| 8 | Transperineurial capillary abnormalities in the sural nerve of patients with diabetic neuropathy显示文摘 | MALIK R A TESFAGE S THOMPSON S D | 1994 | Microvasc Res1994，48，2： | 2 |
| 9 | Compliant control of a two-link flexible manipulator featuring piezoelectric actuators显示文摘 | Kim H K Choi S B Thompson B S | 2001 | Mechanism and Machine Theory2001，，36： | 2 |
| 10 | Use of a land-surface-transfer scheme(LSX) in a global climate model (GENRSIS):The response to doubling stomatal resistance显示文摘 | Pollard D Thompson S L | 1995 | Global Planet Change1995，，10： | 2 |
| 11 | Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial显示文摘 | Matthew T Seymour Lindsay C Thompson Harpreet S Wasan Gary Middleton Alison E Brewster Stephen F Shepherd M Sinead O’Mahony Timothy S Maughan Mahesh Parmar Ruth E Langley | 2011 | The Lancet2011，，9779： | 2 |
| 12 | An Osteoconductive Collagen/Hyaluronate Matrix for Bone Regenerte显示文摘 | Liu L S Thompson A Y Heidaran M A | 1999 | Biomaterials1999，20，12： | 1 |
| 13 | Ferrite Mierostructure in Continuously Cooled Low-and-Ultra Low-Carbon Steels 显示文摘 | Krauss G Thompson S | 1995 | ISIJ International1995，35，6： | 1 |
| 14 | The laws of proportioning concrete显示文摘 | FULLER W B THOMPSON S E | 1907 | Trans ASCE1907，59，： | 1 |
| 15 | Margin Fit of CAD/CAM Produced Crowns 显示文摘 | Rekow E D Thompson V P Yang H S | 1991 | Dental Research1991，70，434： | 1 |
| 16 | Extending a fixed- complexity sphere decoder to obtain likelihood information for Turbo-MIMO systems显示文摘 | Barbero L G and Thompson J S | 2008 | IEEE Transactions on Vehicular Technology2008，57，5： | 1 |
| 17 | Characterization of randomly-obtained matrix attachment regions (MARs) from higher plants显示文摘 | Michalowski S M Alien G C Hall G E Thompson W F Spiker S | 1999 | Biochemistry1999，38，12： | 1 |
| 18 | Interleukin-10 regulates arterial pressure in early primate pregnancy显示文摘 | Orange S Basko JE Thompson JF' | 2005 | Cytokine2005，29，4： | 1 |
| 19 | Improving costing methods in multicentre economic evaluation: the use of multiple imputation for unit costs 显示文摘 | Grieve R Cairns J Thompson S G Thompson | 2010 | Health Economics2010，19，8： | 1 |
| 20 | The Demise of the High Fru- ctose Corn Syrup Futures Contract :A Case Study显示文摘 | THOMPSON S GARCIA P WILDMAN L D | 1996 | Futures Markets1996，16，6： | 1 |
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