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| 1 | Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。 | Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu | 2014 | Cell Research2014，24，5： | 2 |
| 2 | Smart grid technologies: communication technologies and standards显示文摘 | Giingtir V C Sahin D Kocak T | 2011 | IEEE Transactions on Industrial Informatics2011，7，4： | 1 |
| 3 | Progress and recent trends in wind energy显示文摘 | Sahin A D | 2004 | Progress in Energy and Combustion Science2004，30，5： | 1 |
| 4 | Production of human milk fat analogue containing docosahexaenoic and araehidonie acids 显示文摘 | Turan D Sahin Yesil Ubuk N Akoh C C | 2012 | Journal of Agricultural and Food Chemistry2012，60，17： | 1 |
| 5 | A survey on smart grid potential applications and communication requirements显示文摘 | Gungor V C Sahin D Kocak T | 2013 | IEEE Transactions on Industrial Informatics2013，9，1： | 1 |
| 6 | A highly immunogenic and protective middle east respiratory syndrome coro- navirus vaccine based on a recombinant measles virus vaccine platform显示文摘 | Malczyk A H Kupke A Prufer S Scheuplein V A Hutzler S Kreuz D Beissert T Bauer S Hubich Rau S Tondera C Eldin H S Schmidt J Vergara-Alert J Suzer Y Seifried J Hanschmann K M Kalinke U Herold S Sahin U Cichutek K Waibler Z Eickmann M Becker S Muhlebach M D | 2015 | J Virol2015，89，11： | 1 |
| 7 | Smart grid technologies: communication technologies and standards 显示文摘 | Giing6r V C Sahin D Kocak T | 2011 | IEEE Transactions on Industrial Informatics2011，7，4： | 1 |
| 8 | The effects of carnosine in an experimental rat model of septic shock 显示文摘 | Sahin S Oter S Buruko~lu D | 2013 | Med Sci Monit Basic Res2013，19，： | 1 |
| 9 | QT dispersion significantly increases after implantable cardioverter-defibrillator shocks 显示文摘 | Topaloglu S Aras D Sahin O | 2007 | Ann Noninvasive Electrocardiol2007，12，1： | 1 |
| 10 | Progress and recent trends in wind energy显示文摘 | Sahin A D | 2004 | Progress in Energy and Combustion Science2004，30，5： | 1 |
| 11 | Association of the G894T polymorphism of the endothelial nitric oxide synthase gene with diabetic foot syndrome foot ulcer,diabetic complications,and comorbid vascular diseases:a Turkish case-control study显示文摘 | Corapcioglu D Sahin M Emral R | 2010 | Genet Test Mol Biomarkers2010，14，48： | 1 |
| 12 | Analysis of thermophilic clades within the genus streptomyces by 16S ribosomal DNA sequence comparsons 显示文摘 | KIM D CI-IUN J SAHIN N | 1996 | Int J Syst Bacteriol1996，46，1： | 1 |
| 13 | Smart grid technologies : communication technologies and standards 显示文摘 | Gungor V C Sahin D Kocak T | 2011 | IEEE Transactions on Industrial Informatics2011，7，14： | 1 |
| 14 | Smart grid technologies:communication technologies and standards显示文摘 | Gungor V C Sahin D Kocak T | 2011 | IEEE Transactions on Industrial Informatics2011，7，14： | 1 |
| 15 | Minimally Incisional Stabilization of Unstable L5 Burst Fracture显示文摘 | Sahin S Resnick D | | 0，，5： | 1 |
| 16 | Association of the G894T polymorphism of the endothelial nitric oxide synthase gene with dia- betic foot syndrome foot ulcer, diabetic complications, and comorbid vascular diseases: a Turkish case-control study 显示文摘 | Corapcioglu D Sahin M Emral R | 2010 | Genet Test Mol Biomarkers2010，14，4： | 1 |
| 17 | Psychosocial factors affecting various types of intimate partner violence against women显示文摘 | Gulec Oyekcin D Yetim D Melih Sahin E | | 0，，2： | 1 |
| 18 | Uric acid andhigh sensitive C-reactive protein are associated with sub-clinical thoracic aortic atherosclerosis 显示文摘 | Giir M Sahin D Y Elbasan Z | 2013 | J Cardiol2013，61，2： | 1 |
| 19 | First-order Markov chain approach to wind speed modeling 显示文摘 | Sahin A D Sen Z | 2001 | Journal of Wind Engineering and Industrial Aerodynamics2001，89，34： | 1 |
| 20 | In acute organophosphate poisoning,the efficacy of hemoperfusion on clinical status and mortality显示文摘 | Altintop L Aygun D Sahin H | 2005 | Intensive Care Med2005，20，6： | 1 |
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