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| 1 | Influence of irritable bowel syndrome on treatment outcome in gastroesophageal reflux disease显示文摘AIM: To investigate the influence of irritable bowel syndrome (IBS)-like symptoms on treatment outcomes with pantoprazole in gastroesophageal reflux disease (GERD) in a real life setting. METHODS: For this prospective, open-label, multinational, multicentre study, 1888 patients assessed by the investigators as suffering from GERD were recruited. The patients were additionally classified as with or without IBS-like symptoms at baseline. They were treated with pantoprazole 40 mg once daily and completed the Reflux Questionnaire (ReQuest) short version daily. Response rates and symptom scores were compared after 4 and 8 wk of treatment for subgroups defined by the subclasses of GERD [erosive(ERD) and non-erosive reflux disease (NERD)] and the presence of IBS-like symptoms. RESULTS: IBS-like symptoms were more prevalent in NERD than in ERD (18.3% vs 12.7%, P = 0.0015). Response rates after 4 and/or 8 wk of treatment were lower in patients with IBS-like symptoms than in patients without IBS-like symptoms in both ERD (Week 4: P < 0.0001, Week 8: P < 0.0339) and NERD (Week 8: P = 0.0088). At baseline, ReQuest 'lower abdominal com- plaints' symptom scores were highest in NERD patients with IBS-like symptoms. Additionally, these patients had the strongest symptom improvement after treatment compared with all other subgroups. CONCLUSION: IBS-like symptoms influence treatment outcome and symptom burden in GERD and should be considered in management. Proton pump inhibitors can improve IBS-like symptoms, particularly in NERD. | Hubert Mnnikes Robert C Heading Holger Schmitt Hubert Doerfler | 2011 | World Journal of Gastroenterology2011，17，27： | 4 |
| 2 | Cervical inlet patch-optical coherence tomography imaging and clinical significance显示文摘AIM:To demonstrate the feasibility of optical coherence tomography(OCT)imaging in differentiating cervical inlet patch(CIP)from normal esophagus,Barrett'sesophagus(BE),normal stomach and duodenum. METHODS:This study was conducted at the Veterans Affairs Boston Healthcare System(VABHS).Patients undergoing standard esophagogastroduodenoscopy at VABHS,including one patient with CIP,one representative patient with BE and three representative normal subjects were included.White light video endoscopy was performed and endoscopic 3D-OCT images were obtained in each patient using a prototype OCT system.The OCT imaging probe passes through the working channel of the endoscope to enable simultaneous video endoscopy and 3D-OCT examination of the human gastrointestinal(GI)tract.Standard hematoxylin and eosin(H and E)histology was performed on biopsy or endoscopic mucosal resection specimens in order to compare and validate the 3D-OCT data. RESULTS:CIP was observed from a 68-year old male with gastroesophageal reflux disease.The CIP region appeared as a pink circular lesion in the upper esophagus under white light endoscopy.OCT imaging over the CIP region showed columnar epithelium structure,which clearly contrasted the squamous epithelium structure from adjacent normal esophagus.3D-OCT images obtained from other representative patients demonstrated distinctive patterns of the normal esophagus,BE,normal stomach,and normal duodenum bulb.Microstructures,such as squamous epithelium,lamina propria, muscularis mucosa,muscularis propria,esophageal glands,Barrett's glands,gastric mucosa,gastric glands, and intestinal mucosal villi were clearly observed with OCT and matched with H and E histology.These results demonstrated the feasibility of using OCT to evaluate GI tissue morphology in situ and in real-time. CONCLUSION:We demonstrate in situ evaluation of CIP microstructures using 3D-OCT,which may be a useful tool for future diagnosis and follow-up of patients with CIP. | Chao Zhou Tejas Kirtane Tsung-Han Tsai Hsiang-Chieh Lee Desmond C Adler Joseph M Schmitt Qin Huang James G Fujimoto Hiroshi Mashimo | 2012 | World Journal of Gastroenterology2012，18，20： | 3 |
| 3 | SolEmuls ? —novel technology for the formulation of i.v. emulsions with poorly soluble drugs显示文摘 | R.H Müller S Schmidt I Buttle A Akkar J Schmitt S Br?mer | 2003 | International Journal of Pharmaceutics2003，，2： | 3 |
| 4 | Identification and Functional characterization of human CD4+CD25+ T cells with regulatory properties isolated from peripheral blood 显示文摘 | Jonulet H Schmitt E Stassen M | 2001 | J Exp Med2001，9，11： | 3 |
| 5 | Analysis on defect generation during the SiC bulk growth process 显示文摘 | HOFMANN D SCHMITT E BICKERMANN M | 1999 | Mater Sci Eng B1999，6162，： | 2 |
| 6 | Influence of the layer charge and clay particle size on the interactions between the cationic dye methylene blue and clays in an aqueous suspension显示文摘 | NEUMANN M G GESSNER F SCHMITT C C | 2002 | J Colloid Interface Sci2002，255，： | 2 |
| 7 | 移植前供鼠口服受鼠脾细胞对脾细胞移植后GVHD的影响研究显示文摘本研究探讨经口服受鼠脾细胞诱导耐受的供鼠细胞输注是否能减轻移植物抗宿主病(GVHD),并保留的GVL效应。以雄性DBA-2(H-2d)小鼠为供者。供鼠分别用BALB/c鼠脾细胞、DBA-2鼠脾细胞、牛血清蛋白和普通饲料喂养,隔天1次。应用单向混合淋巴细胞反应(MLR)评估诱导耐受状态。以雌性BALB/c小鼠(H-2d)为受者,给予6.0Gy60Coγ射线全身照射,同一天输注3×103鼠白血病细胞,尾静脉输注源于DBA-2小鼠的2×107脾细胞。对照组不给予鼠白血病细胞输注。结果显示,接受已耐受供鼠脾细胞输注的受鼠发生GVHD较其他组轻,流式细胞术检测表明CD4+/CD8+比值增加。接种白血病细胞的受鼠活存率各组间无差别。结论:口服受鼠脾细胞耐受的供鼠,其脾细胞输注给受鼠后GVHD明显减轻,且对GVL效应无影响。 | 陈宝安 邓晓静 丁家华 孙雪梅 董伟民 毕延智 张琰 赵刚 高冲 孙耘玉 王骏 程坚 马燕 宋慧慧 鲍文 Schmitt A Schmitt M | 2008 | 中国实验血液学杂志2008，16，1： | 2 |
| 8 | Identification and functional characterization of human CD4^+ CD25^+ T cells with regulatory properties isolated from peripheral blood显示文摘 | Jonuleit H Schmitt E Stassen M | 2001 | J Exp Med2001，193，11： | 1 |
| 9 | Chronic myeloid leukemia cells express tumor-associated antigens eliciting specific CD8 + T-cell responses and are lacking costimulatory molecules显示文摘 | LI L GIANNOPOULOS K | 2006 | Exp Hematol2006，34，12： | 1 |
| 10 | Properties and struc- tures of tin borophosphate glasses显示文摘 | Lira J W Schmitt M L Brow R K | 2010 | Journal of Non-Crystal- line Solids2010，356，： | 1 |
| 11 | Identification and characterization of the bovine herpesvirus 1 UL7 gene and gene product which are not essential for virus replication in cell culture 显示文摘 | Schmitt J Keil G M | 1996 | J Virol1996，70，2： | 1 |
| 12 | Simple Photon Diffusion Analysis of the Effects of Multiple Scattering on Pluse Oximetry 显示文摘 | Schmitt J M | 1991 | IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING1991，38，12： | 1 |
| 13 | Changes during isolation and culture of tobacco mesophyll protopiasts显示文摘 | Gigot C Kopp M Schmitt C | 1975 | Protoplasma1975，84，： | 1 |
| 14 | Long-term follow-up of pseud-oexfoliation and the development of elevated intraocular pres-sure显示文摘 | Henry J C Krupin T Schmitt M | 1987 | Ophthalmology1987，94，： | 1 |
| 15 | On the G1 continuity of piecewise Bézier surface: a review with new results显示文摘 | Wen-Hui Du and Francis J M Schmitt | 1990 | Computer-Aided Design1990，22，9： | 1 |
| 16 | The Lateral suppressor (LS) gene of tomato encodes a new member of the VHIID protein family显示文摘 | Schumacher K Schmitt T Rossberg M | 1999 | Proc Natl Acad Sci1999，96，： | 1 |
| 17 | The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor显示文摘 | Hudecek M Schmitt T M Baskar S | 2010 | Blood2010，116，22： | 1 |
| 18 | The B-cell tumorassociated antigen ROR1can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor显示文摘 | Hudecek M Schmitt TM Baskar S | 2010 | Blood2010，116，： | 1 |
| 19 | Characterization of Pore Systems in Seal Rocks Using Nitrogen Gas Adsorption Combined with Mercury Injection Capillary Pressure Techniques 显示文摘 | Schmitt M Fernandes C P da Cunha Neto J A B | 2013 | Marine and Petroleum Geology2013，39，1： | 1 |
| 20 | New aspects on the pathogenesis, diagostic procedures, and therapeutic management of chronic lymphocytic leukemia显示文摘 | WENDTNER C M SCHMITT B BERGMANN M | 2001 | Int J Hematol2001，73，1： | 1 |
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