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| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | Indian medicinal plants (Mexico) : Inhibitory activity on NF-kappa B as an anti-inflammatory model and antibacterial effects 显示文摘 | Bork P M Schmitz M L Weimann C | 1996 | Phytomedicine1996，3，3： | 1 |
| 3 | Augmened vasoconstrictor response to serotonin precede development of artherosclerosis in aorta of WHHL rabbit显示文摘 | WINES P A SCHMITZ J M PFISTER S L | 1989 | Atheriosclerosis1989，9，2： | 1 |
| 4 | Soluble, Rigid-rod Polyimides with Dye-containing Side Groups v/a a Novel Precursor Route 显示文摘 | Schmitz L Rehahn M | 1993 | Macromolecules1993，26，17： | 1 |
| 5 | An investigation of the dynamic absorber effect in high speed machining 显示文摘 | Duncan G S Tummond M F Schmitz T L | 2005 | International Journal of Machine Tools & Manufacture2005，45，45： | 1 |
| 6 | The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B 显示文摘 | Schmitz M L Baeuerle P A | 1991 | EMBO J1991，10，12： | 1 |
| 7 | An inves- tigation of the dynamic absorber effect in high-speed machining显示文摘 | Duncan G S Tummond M F Schmitz T L | 2005 | International Journal of Machine Tools and Manufacture2005，45，45： | 1 |
| 8 | An investigation of the dynamic absorber effect in high-speed machining显示文摘 | DUNCAN G S TUMMOND M F SCHMITZ T L | 2005 | International Journal of Machine Tools & Manufacture2005，45，45： | 1 |
| 9 | NF-kap- paB: a multifaceted transcription factor regulated at several levels显示文摘 | Schmitz M L Mattioli I Buss H Kracht M | 2004 | Chembiochem2004，5，： | 1 |
| 10 | Treatment and prognosis of mature T-cell and NK-cell lymphoma: an analysis of patients with T-cell lymphoma treated in studies of the German High-Grade Non-Hodgkin Lymphoma Study Group显示文摘 | Schmitz N Trümper L Ziepert M | 2010 | Blood2010，116，18： | 1 |
| 11 | Identification of a novel coronavirus in patients with severe acute respiratory syndrome显示文摘 | Gunther S Preiser W van der Weft S Brodt HR Becker S Rabenau H Panning M Kolesnikova L Fouchier RA Berger A Burguiere AM Cinatl J Eickmann M Escriou N Grywna K Kramme S Manuguerra JC Muller S Rickerts V Sturmer M Vieth S Klenk HD Osterhaus AD Schmitz H Doerr HW | 2003 | N Engl J Med2003，348，： | 1 |
| 12 | Comparative system analysis of direct steam generation and synthetic oil parabolic trough power plants with integrated thermal storage 显示文摘 | Feldhoff J F Schmitz K Eck M Schnatbaum-Laumann L Laing D Ortiz-Vives F Schulte-Fischedick J | 2012 | Solar Energy2012，86，： | 1 |
| 13 | VSIG4, a B7 family-related protein, is a negative regulator of T cell activation显示文摘 | Vogt L Schmitz N Kurrer M O | 2006 | J Clin Invest2006，116，10： | 1 |
| 14 | Improving high speed machining material removal rates by rapid dynamics analysis显示文摘 | Schmitz T L Davies M A Medicus K | 2001 | Annals of the CIRP2001，50，1： | 1 |
| 15 | Adenovirus-mediated CD40 ligand gene therapy in a rat model of orthotopic hepatocellular carcinoma 显示文摘 | Schmitz V Barajas M Wang L | 2001 | Hepatology2001，34，1： | 1 |
| 16 | Hospitalized patients with2009H1N1influenza in the United States,April-June2009显示文摘 | Jain S Kamimoto L Bramley AM Schmitz AM Benoit SR Louie J Sugerman DE Druckenmiller JK Ritger KA Chugh R Jasuja S Deutscher M Chen S Walker JD Duchin JS Lett S Soliva S Wells EV Swerdlow D Uyeki TM Fiore AE Olsen SJ Fry AM Bridges CB Finelli L 2009Pandemic Influenza A(H1N1)Virus Hospitalizations Investigation Team | 2009 | N Engl J Med2009，361，20： | 1 |
| 17 | Treatment and prognosis of mature T-cell and NK-cell lymphoma: an analysis of patients with T-cell lymphoma treated in studies of the German High-Grade Non-Hodgkin Lymphoma Study Group显示文摘 | Schmitz N Trtimper L Ziepert M | 2010 | Blood2010，116，18： | 1 |
| 18 | Treatment and prognosis of mature T-ceil and NK-cell lymphoma: an analysis of patients with T-cell lymphoma treated in studies of the German High-Grade Non-Hodgkin Lymphoma Study Group 显示文摘 | Schmitz N Trumper L Ziepert M | 2010 | Blood2010，116，18： | 1 |
| 19 | Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance显示文摘 | Bonapace L Bornhauser BC Schmitz M | 2010 | J Clin Invest2010，120，4： | 1 |
| 20 | Neuropsychological performance in DSM-IV ADHD subtypes,an exploratory study with untreated adolescents显示文摘 | Schmitz M Cadore L Paczko M | 2002 | Can J Psychiatry2002，47，9： | 1 |
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